提炼
肾脏参与了许多生理过程,包括液体和电解质平衡。肾功能与阻塞性气道疾病有关,但是这种关系的性质很难取消[1]。具体而言,尚不清楚肾脏功能是影响气道疾病还是vice versa,或者是否相反attributab协会le to confounding factors. Insight into the nature of this relationship is of clinical relevance, as the identification of renal impairment as a causal risk factor for obstructive lung disease would offer mechanistic insight and therapeutic opportunities. However, conventional observational studies exploring this have been unable to infer causation, due to the possibility of unmeasured or unknown environmental confounding and reverse causation [2].
抽象的
总而言之,Sehoon Park和同事进行了一系列优雅的Mendelian随机分析,以全面而系统地取消肾功能与阻塞气道疾病之间的关联https://bit.ly/3uRyAyA
脚注
Conflict of interest: D. Gill is employed part-time by Novo Nordisk.
利益冲突:S。Burgess没有什么可披露的。
- Received2021年5月11日。
- 公认2021年5月28日。
- 版权所有©作者2021。用于复制权和权限联系权限{at} ersnet.org
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