抽象
这项研究的目的是评估和比较剂量输送和压力定量吸入器(PMDI)的剂量可变性/中喘息日常生活中的婴儿和垫片,以探讨影响气雾剂递送因素。在25开放的随机交叉研究喘鸣婴儿年龄5-26个月,一金属隔板(Nebuchamber),涂(DC)和包衣(nonDC)塑料垫片(Babyhaler)非洗涤剂的洗涤剂在家测试7天每。布地奈德(200微克b.i.d)经由经由Babyhaler一个Nebuchamber或氟替卡松(125微克b.i.d)施用。气雾剂被困在过滤器,位于该间隔物和面罩之间。合作进行评分在日记卡上。间隔件的静电电荷(ESC)进行测定。管理技术的评价是从录像制作。表示为每标称剂量的百分之(%)过滤器的中位数(范围)的剂量递送,是34%(3-59),23%(1-49),和41%(12-55),用于在Nebuchamber,nonDC-Babyhaler和DC-Babyhaler分别。当与两个nonDC-(36%相比,相当大的剂量的变异被发现,中位数(范围)内,对象剂量变异性,表示为变异系数,对于Nebuchamber(49%(15-249))为显著升高(12-325))和DC-Babyhalers(27%(10-122)),为此,剂量可变性是相似的。 Detergent coating was effective to reduce electrostatic charge, and to increase dose delivery, but had no effect on dose variability. Bad cooperation was an important cause for high dose variability for all spacers (r=0.5-0.6, p<0.02). Many mistakes were made during the administration procedure.