文摘
与健康人群相比,远端气道细菌殖民化可能发生在慢性肺部疾病患者,经常改变肺防御。然而,信息处理这个问题是不够的,主要基于特异性的样本,如痰文化。使用定量的支气管镜的文化保护标本刷(公安局)和支气管肺泡灌洗(BAL)样品,我们研究了细菌殖民化的远端航空公司在16个健康受试者,33支气管癌患者,18与慢性阻塞性肺疾病(COPD), 17与支气管扩张,32长期因喉癌气管造口术。所有患者没有恶化,无抗生素治疗前至少1个月研究协议。阈值量化定义殖民文化>或= 10(2)菌落(cfu) x mL(1)公安局和> = 10 (3)cfu x mL(1)落下帷幕。只有一个健康的主题是殖民地的一个潜在的致病微生物(PPM)(金黄色葡萄球菌4 x10 (2) cfu x mL(1)在一个公安局的文化)。殖民在14名(42%)支气管癌患者(19 non-PPMs,和10个项目组合管理系统);15(83%)慢性阻塞性肺病患者(22 non-PPMs 7项目组合管理系统);15(88%)支气管扩张患者(20 non-PPMs和13个项目组合管理系统);15(47%)和长期的气管造口患者(5 non-PPMs和13个项目组合管理系统)。 The two most frequent non-PPMs isolated in all groups studied were Streptococcus viridans and Neisseria spp. Haemophilus spp., Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were the most frequent PPMs isolated in bronchogenic carcinoma, COPD, bronchiectasis and long-term tracheostomized patients, respectively. Pseudomonas aeruginosa colonization was infrequent in all the groups. Our results show that distal airway bacterial colonization is a frequent feature in stable patients with chronic lung diseases and also in patients with long-term tracheostomy. However, the pattern of colonization differs among groups studied. The knowledge of different colonization patterns may be important for future antibiotic prophylactic strategies and for the empirical antibiotic regimens when exacerbations occur in these patients.