TY -的T1 -细菌殖民化的远端航空公司在健康受试者和慢性肺部疾病:支气管镜的研究摩根富林明-欧洲呼吸杂志》乔欧元和J SP - 1137 LP - 1144 - 10.1183 / 09031936.97.10051137六世- 10 - 5盟卡贝略港,H AU -托雷斯,非盟——附加评论,R盟——El-Ebiary M AU - Puig de la Bellacasa, J盟——Xaubet AU -冈萨雷斯,J盟——Agusti C盟——太阳系,N Y1 - 1997/05/01 UR - //www.qdcxjkg.com/content/10/5/1137.abstract N2 -与健康人群相比,远端气道细菌殖民化可能发生在慢性肺部疾病患者,经常改变肺防御。然而,信息处理这个问题是不够的,主要基于特异性的样本,如痰文化。使用定量的支气管镜的文化保护标本刷(公安局)和支气管肺泡灌洗(BAL)样品,我们研究了细菌殖民化的远端航空公司在16个健康受试者,33支气管癌患者,18与慢性阻塞性肺疾病(COPD), 17与支气管扩张,32长期因喉癌气管造口术。所有患者没有恶化,无抗生素治疗前至少1个月研究协议。Thresholds for quantitative cultures to define colonization were > or = 10(2) colony-forming units (cfu) x mL(-1) for PSB and > or = 10(3) cfu x mL(-1) for BAL. Only one healthy subject was colonized by a potential pathogenic microorganism (PPM) (Staphylococcus aureus 4x10(2) cfu x mL(-1) in a PSB culture). Colonization was observed in 14 (42%) bronchogenic carcinoma patients (19 non-PPMs, and 10 PPMs); in 15 (83%) COPD patients (22 non-PPMs and 7 PPMs); in 15 (88%) bronchiectasis patients (20 non-PPMs and 13 PPMs); and in 15 (47%) long-term tracheostomy patients (5 non-PPMs and 13 PPMs). The two most frequent non-PPMs isolated in all groups studied were Streptococcus viridans and Neisseria spp. Haemophilus spp., Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were the most frequent PPMs isolated in bronchogenic carcinoma, COPD, bronchiectasis and long-term tracheostomized patients, respectively. Pseudomonas aeruginosa colonization was infrequent in all the groups. Our results show that distal airway bacterial colonization is a frequent feature in stable patients with chronic lung diseases and also in patients with long-term tracheostomy. However, the pattern of colonization differs among groups studied. The knowledge of different colonization patterns may be important for future antibiotic prophylactic strategies and for the empirical antibiotic regimens when exacerbations occur in these patients. ER -