Extract
Obstructive sleep apnoea (OSA) is a prevalent respiratory disease associated with important comorbidities, such as obesity, metabolic syndrome, cancer, and cognitive and cardiovascular alterations [1, 2]. Unfortunately, determining cause–effect relationships that definitively link OSA to these comorbidities and establishing whether OSA treatment may reduce the comorbidity risk have emerged as conundrums that have proven very difficult to disentangle in spite of major research efforts [3–5]. These difficulties have emerged as particularly relevant when focusing on the potential relationship between OSA and cardiocirculatory diseases [6, 7]. Indeed, a simple search (12 April, 2021) in PubMed for the past 12 months using the tags “sleep apnoea AND cardiovascular” (563 publications) and “sleep apnoea” (3300 publications) indicates that 17% of all the research in the field of OSA is focused on its putative relationship with cardiovascular dysfunction.
Abstract
Experimental models in healthy subjects and patients are useful to complement cell culture and animal research in studying the pathophysiology of obstructive sleep apnoea consequences https://bit.ly/3nKPFsl
Footnotes
Conflict of interest: R. Farré has nothing to disclose.
Conflict of interest: D. Gozal has nothing to disclose.
Conflict of interest: I. Almendros has nothing to disclose.
- Received April 23, 2021.
- Accepted April 26, 2021.
- Copyright ©The authors 2021. For reproduction rights and permissions contact permissions{at}ersnet.org