Extract
The End TB Strategy, proposed by the World Health Organization (WHO) in 2014, calls for a 90% reduction in tuberculosis (TB)-related deaths and an 80% reduction in TB incidence by 2030 [1]. TB remains a leading cause of death in children under 5 years of age [2], and interventions to eliminate preventable child deaths from TB are urgently needed. Additional and effective TB prevention measures are crucial for the End TB Strategy goals to be met [3].
Abstract
This study proposes a revised synchronised and pragmatic dosing table for the 3HP regimen in children that utilises available formulations. The revised doses are predicted to deliver adequate rifapentine and isoniazid exposure in children. https://bit.ly/3eUHm86
Footnotes
Conflict of interest: K.K. Radtke has nothing to disclose.
Conflict of interest: J.E. Hibma is an employee of Pfizer Inc.
Conflict of interest: A.C. Hesseling has nothing to disclose.
Conflict of interest: R.M. Savic has nothing to disclose.
Support statement: This work was supported by the National Institutes of Health (grant: R01AI135124-01A). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received May 13, 2020.
- Accepted June 26, 2020.
- Copyright ©ERS 2021