抽象的
嗜酸性粒细胞涉及哮喘的效应细胞,但气道墙中嗜酸性粒细胞的精确定位的功能意义差不多。我们的目标是在气道墙的不同隔室中量化嗜酸性粒细胞,并将这些发现与哮喘和气道炎症标记的临床特征联系起来。
在这种横截面研究中,我们利用基于设计的立方体学,以准确地分配上皮舱和诸着嗜纤维空间(基底层薄膜下方的气道壁面积)在具有和没有哮喘的个体中的噬粒细胞(气道壁区域)中的数量密度这些调查结果对Airway HyperRessiveness(AHR)和气道炎症的特征。
上皮内嗜酸性粒细胞与哮喘和内源AHR的存在相关,哮喘最特异的AHR的类型。相比之下,术前皮和耻骨上皮嗜酸性粒细胞均与2型(T2)炎症有关,之间的最强关联il5.expression and intraepithelial eosinophils. Eosinophil infiltration of the airway wall was linked to a specific mast cell phenotype that has been described in asthma. We found that IL-33 and IL-5 additively increased cysteinyl leukotriene (CysLT) production by eosinophils and that the CysLT LTC4随着IL-33的增加IL13expression in mast cells and altered their protease profile.
We conclude that intraepithelial eosinophils are associated with endogenous AHR and T2 inflammation and may interact with intraepithelial mast cellsviaCyslts调节气道炎症。
脚注
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Conflict of interest: Dr. Al-Shaikhly reports In addition, Dr. Al-Shaikhly has a patent MicroRNAs as Predictors of Response to Anti-IgE Therapies in Chronic Spontaneous Urticaria pending.
Conflict of interest: Ryan C. Murphy has nothing to disclose.
Conflict of interest: Andrew Parker has nothing to disclose.
兴趣冲突:英莱没有什么可披露的。
利益冲突:马修C. Altman向提交的工作之外向Sanofi-Regeneron报告个人费用。
Conflict of interest: Megan Larmore has nothing to disclose.
利益冲突:Altemeier博士报告了NIH的赠款,在研究期间进行了研究。
Conflict of interest: Charles W. Frevert has nothing to disclose.
兴趣冲突:杰森斯。迪尔比在研究中报告了国家卫生研究所的补助金。
Conflict of interest: Dr. Piliponsky reports grants from National Institute of Health, outside the submitted work.
Conflict of interest: Steven F. Ziegler has nothing to disclose.
兴趣冲突:彼得斯博士报告来自博登尼姆的NIH-NHLBI的赠款,来自Boeringer-Ingelheim,在该研究中进行;来自AstraZeneca,Boehringer-Ingelheim,Genentech,Glaxosmithkline,Sanofi-genzyme-Regeneron和Teva的赠款,外部提交的工作之外。
Conflict of interest: Dr. Hallstrand reports grants from NIH, during the conduct of the study; grants from NIH, outside the submitted work.
- 已收到July 2, 2021.
- Accepted2021年12月6日。
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