摘要
本研究旨在探讨猪养殖户是否存在支气管黏膜炎症和支气管肺泡灌洗(BAL)细胞的激活。养猪户暴露在高水平的粉尘环境中,出现了与工作有关的呼吸道症状。对27例未吸烟的大型养猪户进行支气管镜检查和BAL检查。53名终身不吸烟的健康学生作为对照。所有农民和对照组的肺功能正常(1秒用力呼气量(FEV1)分别为109和105%)。对支气管炎症的宏观体征(红斑、水肿、分泌物和脆性)的估计表明,养猪户的炎症体征明显增加。中位评分为3分(范围0-6),而对照组中位评分为0分(范围0-3)。与对照组相比,更多的猪农(41%对25%)组胺激发阳性(激发剂量使FEV1下降20% (PC20) <或= 32 mg.mL-1),但差异不显著。两组BAL液中细胞浓度相同。与对照组相比,养猪户淋巴细胞(中位数为7,范围为1-27,中位数为2,范围为0-7)和中性粒细胞(中位数为2,范围为0-30,中位数为1,范围为0-4)的百分比显著增加。 Spontaneous migration (19.8 versus 5.5 microns) and chemotaxis (62.6 versus 11.2 microns) was significantly increased in pig farmers compared to controls. After stimulation with zymosan and phorbol myristrate acetate (PMA), the reactive oxygen radical generation of purified alveolar macrophages was also significantly increased in pig farmers. Lifetime nonsmoking pig farmers with normal lung function have macroscopic signs of bronchial inflammation and an increased number of neutrophils in bronchoalveolar lavage. Their alveolar macrophages showed biological signs of activation. The inflammation of pig farmers bronchi may be early signs of bronchitis.