抽象
最近的高分辨率计算断层扫描(HRCT)最近被证明与开放性肺活检一样好,用于诊断硬皮病患者的肺部受累。尽管如此,鉴于其价格和相关辐照,HRCT不能推荐作为筛选试验。血清III Procollagen(SpiiinP)是III型胶原蛋白的氨基丙肽,其在转化过程中通过特定蛋白酶转化为胶原蛋白。患有硬皮病患者的患者已经观察到孢子苷水平增加。本研究的目的是评估根据HRCT和肺功能试验(PFT)定义的SPIIINP测量和肺部受累的关系,其中28例患有硬皮病的28名患者中单呼吸一氧化碳转移能力(TL,CO)。患者分为分析两组,A组包含16名没有肺硬化蛋白和B组的患者,包括12名肺硬化蛋白患者。所有患者均具有稳定的皮肤病和正常的肾和肝功能。Spiiinp的水平由放射免疫测定(Ria-gnost p-III-P,Prod.NR.ODMT; Behring,Marburg,德国)。A组中的平均+/- SD SpiiinP水平为0.85 +/- 0.21 U.ML-1。单个值范围为0.6-1.3 U.ML-1。 Mean +/- SD sPIIINP value was 1.30 +/- 0.40 U.mL-1 in Group B and individual values ranged 0.7-1.9 U.mL-1. The difference in mean sPIIINP level between Group A and Group B was significant. Using a cut-off at 1.1 U.mL-1, sensitivity of sPIIINP was 0.66, specificity 0.94, positive predictive value 0.89, negative predictive value 0.79, false positive rate 0.06, and false negative rate 0.33. The value of sPIIINP correlated with HRCT score but not with PFT. This study confirms the relationship between sPIIINP and scleroderma with interstitial lung disease. We suggest that sPIIINP could be measured in patients with scleroderma to screen those patients requiring HRCT. Further studies are necessary to determine the value of sPIIINP in terms of prognosis and follow-up of patients under treatment.