文摘
异常的患病率在肺弹性患者哮喘或慢性阻塞性肺疾病(COPD)仍不清楚。这可能是由于不确定性关于通货紧缩的准静态分析肺压力-容积曲线的方法。压力-容积曲线在99年获得了比较严重的哮喘或慢性阻塞性肺病患者。这些患者被一群荷兰多中心试验;整个组的基础上选择一个适度降低%预计在一秒用力呼气量(FEV1),和一个挑衅的组胺浓度生产FEV1下降了20% (PC20) < 8毫克。mL-1获得2分钟潮汐的呼吸技巧。曲线被安装了一个指数(E)模型和指数模型的线性出现在中期肺活量范围考虑(linear-exponential (LE))。linear-exponential模型明显表现出更好的适应能力,产生额外的参数,合规等功能余气量(FRC)水平作为线性部分的斜率(b),和体积的线性部分变成了指数曲线的一部分(过渡卷(录像机))。录像机(平均值录像机/肺活量(TLC) = 0.79(标准差0.07))显示与障碍和恶性通货膨胀变量密切正线性相关,这可能是由于气道关闭,已经从高架肺容积。指数与b和形状系数K是密切相关的平均值(K = 1.32(标准差0.05)kPa-1;1.16 b = 2.96 (SD) L, kPa-1)和与年龄的关系相当健康个体的数据报告。 The shape factor of the linear-exponential fit showed no correlation with any elasticity related variable. Neither the elastic recoil at 90% TLC, as obtained from the linear-exponential fit, nor its relationship with age were significantly different from healthy individuals. We conclude that, for a more accurate description of the lung pressure-volume curve, a linear-exponential fit is preferable to an exponential model. However, the physiological relevance of the shape parameter (KLE) is still unclear. These results indicate that patients with moderately severe asthma or COPD had, on average, no appreciable loss of elastic lung recoil as compared with healthy individuals.