文摘
食盐水的吸入气溶胶是一个相对无创性方法获得痰检查气道的炎症过程。我们调查了一些技术因素可能会影响诱导痰细胞计数的成功。总共二十6哮喘和13名健康受试者,无法提高痰自发,吸入喷雾盐水三个7分钟的间隔。在三个随机交叉研究中我们反复痰诱导在分开的日子里,有两个超声波喷雾器(De Vilbiss Ultraneb 99和Fisoneb)和一个喷气喷雾器(帕里会主压缩机)(研究1,n = 15),与不同盐水浓度(0.9%生理盐水;3%高渗盐水2天;和高渗盐水3、4和5%,按顺序)(研究2 n = 14)和预处理与舒喘灵或安慰剂(研究3,n = 10)。后两个双盲研究。与二硫苏糖醇痰细胞分散,细胞悬液是用来执行总细胞数和准备cytospins微分细胞计数。我们成功率相比,细胞计数,不适和百分比下降在一秒用力呼气量(FEV1)在程序。所有痰检查盲的临床过程。 The success rates and the cell counts of the specimens obtained with the two ultrasonic nebulizers were not different, whilst general discomfort was proportional to the saline output of the nebulizer. Induction of sputum by hypertonic saline was more successful than normal saline, but more disagreeable to the subjects. Induction with saline 3% on two days was only successful in 6 of 14 subjects.(ABSTRACT TRUNCATED AT 250 WORDS)