摘要
干粉吸入器(如Turbuhaler)的有效使用依赖于产生足够的吸气流量。目前尚不清楚急性哮喘患者是否能够产生足够的流量。通过空Turbuhaler测量峰值吸气流量(PIF),并在没有该设备的情况下,对99名急性哮喘发作的成人进行测量。在可能的情况下,在雾化支气管扩张剂治疗之前对患者进行研究。平均(SD) 1秒用力呼气量(FEV1)为1.2 (0.7)L,用力肺活量(FVC)为2.1(1.0)L,峰值呼气流量(PEF)为199 (92)L.min-1。未使用Turbuhaler的PIF为152 (77)L.min-1,与PEF相关(r = 0.69)。通过Turbuhaler的PIF为60 (20)L.min-1,与PEF呈弱相关(r = 0.35),与不使用Turbuhaler的PIF呈弱相关(r = 0.43)。2例患者未能产生有效使用Turbuhaler所需的最小吸气流量(30 L.min);两者均录得26 L.min-1。急性哮喘与大量吸气和呼气气流限制有关。 The relationship between inspiratory and expiratory airflow is not strong enough to predict whether patients with severe acute asthma will have difficulty using dry powder inhalers efficiently. Despite this, 98% of patients in this study generated inspiratory flow through Turbuhaler which would allow a therapeutically active amount of bronchodilator drug to be delivered to the airways.