提炼
COPD是与年龄相关的疾病,与细胞衰老有关[1]。在COPD中,细胞衰老的贡献者包括吸烟和持续性肺部炎症等环境因素的氧化应激[2]。这些因素还可以增强复制性衰老,其特征是进行性端粒损耗,最终导致细胞周期停滞和死亡。与对照组相比,COPD患者的端粒较短[3]和更快的端粒损耗率[4];但是,COPD中细胞或复制性衰老的临床影响仍然不确定。
Abstract
Epigenetic blood biomarkers of cellular and replicative senescence may improve the clinical assessment of COPD patients, particularly for those at a higher risk of deathhttps://bit.ly/3nem7tp
Footnotes
利益冲突:A.I。埃尔南德斯·科德罗(Hernandez Cordero)无话可说。
Conflict of interest: C.X. Yang has nothing to disclose.
利益冲突:米尔恩没有什么可披露的。
Conflict of interest: X. Li has nothing to disclose.
利益冲突:Z. Hollander报告了加拿大基因组,不列颠哥伦比亚基因组,基因组魁北克,加拿大卫生研究院,卓越证明中心,圣保罗医院基金会和Providence Health Care for Repucy Transition(RTP)同学的资金包括在手稿中。
Conflict of interest: V. Chen reports funding from Genome Canada, Genome British Columbia, Genome Quebec, the Canadian Institutes of Health Research, PROOF Centre of Excellence, St. Paul's Hospital Foundation and Providence Health Care for the Rapid Transition Program (RTP) cohort included in the manuscript.
利益冲突:R。NG报告加拿大基因组,不列颠哥伦比亚基因组,基因组魁北克,加拿大卫生研究院,卓越证明中心,圣保罗医院基金会和Providence Health Care for Repad Transition for Repad Transition计划(RTP)同事包括在手稿中。
Conflict of interest: S.J. Tebbutt has nothing to disclose.
Conflict of interest: J.M. Leung reports research grant funding (to institution) from Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, BC Lung Association and Genome BC, outside the scope of the current manuscript.
Conflict of interest: D.D. Sin declares grants from AstraZeneca for an investigator-initiated randomised controlled trial in COPD; consulting fees from Novaira for sitting on an advisory board for COPD; and honoraria for speaking engagements from AstraZeneca, Boehringer Ingelheim and Grifols, all in the 36 months prior to manuscript submission.
支持声明:由加拿大基因组,不列颠哥伦比亚基因组,魁北克基因组,加拿大卫生研究院,普罗维登斯医疗保健,圣保罗医院基金会以及防止器官衰竭中心的支持。A.I.Mitacs和Providence Airway Center支持Hernandez Cordero和S. Milne。J.M. Leung获得了迈克尔·史密斯(Michael Smith)健康研究基金会健康专业研究员奖和CIHR/阿斯利康早期职业研究员奖的支持。R. Ng是加拿大1级研究主席,D.D。Sin是COPD的1级研究主席,并担任心脏肺部创新中心的De Lazzari家庭主席。
- Received2021年7月5日。
- 公认September 9, 2021.
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