Extract
Obstructive sleep apnoea (OSA) and non-alcoholic fatty liver disease (NAFLD) are two of many diseases associated with obesity. NAFLD is a common condition ranging in severity from liver steatosis to non-alcoholic steatohepatitis and liver fibrosis, the last step of NAFLD progression. Numerous studies have investigated whether the frequent co-occurrence of OSA and NAFLD simply reflects their link to obesity, or whether there is an independent pathophysiological interconnection between the two diseases (see [1] for comprehensive review). In animal models, intermittent hypoxia mimicking OSA has been shown to cause insulin resistance, dysfunction of key steps in hepatic lipid metabolism, liver steatosis and fibrosis [1].
Abstract
In patients with OSA and metabolic comorbidities, liver steatosis measured by magnetic resonance imaging is associated with male sex and insulin resistance, but not with OSA severity and nocturnal hypoxia http://bit.ly/2kqyi3O
Acknowledgements
The METABOL Group: Département de Pneumologie, CHU, Angers, France: Nicole Meslier, Pascaline Priou; Service d'Hépato-gastroentérologie, CHU, Angers, France: Frédéric Oberti, Isabelle Fouchard-Hubert, Adrien Lannes, Sandra Girres; Département d'Endocrinologie, Diabétologie, Nutrition, CHU, Angers, France: Ingrid Allix; Département de Médecine du Sport et Explorations Fonctionnelles Vasculaires, CHU, Angers, France: Georges Leftheriotis; INSERM UMR 1063 “SOPAM”, Univeristé d'Angers, Angers, France: Carmen Martinez, Soazig Le Lay, Raffaella Soleti, Luisa Vergori; Département de la Recherche Clinique et Innovation, CHU, Angers, France: Jean-Marie Chrétien; Centre de Resource Biologique, CHU, Angers, France: Odile Blanchet, Belaid Sekour; Laboratoire HIFIH, EA3859, Université d'Angers, France: Gilles Hunault.
Footnotes
Conflict of interest: W. Trzepizur has nothing to disclose.
Conflict of interest: J. Boursier has nothing to disclose.
Conflict of interest: A. Berréhare has nothing to disclose.
Conflict of interest: M. Le Vaillant has nothing to disclose.
Conflict of interest: R. Andriantsitohaina has nothing to disclose.
Conflict of interest: P-H. Ducluzeau has nothing to disclose.
Conflict of interest: S. Dubois has nothing to disclose.
Conflict of interest: S. Henni has nothing to disclose.
Conflict of interest: P. Abraham has nothing to disclose.
Conflict of interest: P. Calès has nothing to disclose.
Conflict of interest: C. Aubé has nothing to disclose.
Conflict of interest: A. Paisant has nothing to disclose.
Conflict of interest: F. Gagnadoux has nothing to disclose.
- Received July 30, 2019.
- Accepted September 11, 2019.
- Copyright ©ERS 2020