抽象的
目标:为了制定对表型的敏感CT结局指标,并在支气管扩张(BE)患者中量化肺部疾病。
方法:Collection of the most recent CT scan of BE patients with chronic Pseudomonas aeruginosa infection enrolled in the iBEST-1 study, an RCT of inhaled tobramycin. Volumetric CT scans with a slice thickness ≤ 3 mm were included. In the BE scoring technique for CT (BEST-CT), grid cells were annotated on 10 axial slices. Scoring items in hierarchical order: consolidation/ atelectasis, BE with mucus plugging (MP), BE without MP, airway wall thickening (AWT), MP, ground-glass opacities (GGO), emphysema/ bullae, healthy airways, and healthy parenchyma. Low attenuation regions were scored on expiratory scans. Subscores are expressed as median [IQR] as % of total lung volume. CT scans were also scored using the Hartmann method developed for immunodeficiency patients, and 20 scans were rescored for agreement analyses.
结果:我们收集了99张CT扫描,其中包括85张CT扫描。中位数为3.0%[1.4-5.1],MP 2.7%[1.5-6.1],AWT 0.1 [0-0.2],总气道疾病(BE + MP + AWT)6.2%[3.4-11.8],合并/ atelectasis 1.5%[0.6-3.2],GGO 0.3%[0.1-1.1]和肺气肿/ Bullae 0%[0-0]总肺部量。此外,肺不张/巩固(84/85),MP(83/85),GGO(68/85)和AWT(55/85)是最常见的注释异常。肺气肿/小牛被注释最少(13/85)。要进行:与Hartmann方法进行互际观察者一致性分析和比较。
Conclusion:最佳CT是BE的定量评分方法。在临床试验中,可用于表型和作为结果度量。
脚注
引用本文为:2019年欧洲呼吸杂志;54:补充。63,PA4817。
这是国际国际大会摘要。没有全文版本可用。此摘要可能还有其他材料www.ers-education.org(仅ERS成员访问)。
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