Sex |
Female |
Female |
Male |
Age at asthma onset years |
15 |
6 |
6 |
Age at asthma loss of control years |
36 |
54 |
62 |
Age atJAK2mutation diagnosis years |
38 |
55 |
65 |
Atopy |
Yes |
Yes |
Yes |
FEV1% pred |
43 |
80 |
90 |
Blood eosinophil maximum count per mm3 |
5540 |
4510 |
2000 |
Platelet count per mm3 |
670 000 |
315 000 |
320 000 |
Haemoglobin level g·dL−1 |
15 |
13.5 |
16.6 |
Bronchoalveolar lavage |
|
|
NA |
Total cell count per mL |
340 000 |
260 000 |
|
Macrophages % |
15 |
10 |
|
Lymphocytes % |
5 |
0 |
|
Neutrophils % |
5 |
5 |
|
Eosinophils % |
75 |
85 |
|
Lung CT scan |
Bilateral infiltrates |
Bilateral infiltrates |
Infiltrates in right middle lobe |
Other organ involved |
慢性urticaria, radial artery thrombosis |
None |
Recurrent pulmonary embolism and deep vein thrombosis |
Vitamin B12 level#pmol·L−1 |
1200 |
810 |
NA |
T-cell clone in peripheral blood |
No |
Yes |
No |
Bone marrow biopsy results |
Myeloproliferative disorder |
Normal |
Normal |
Actual treatment |
Hydroxyurea Prednisone 10 mg per day Warfarin High-dose ICS |
Prednisone 9 mg per day High-dose ICS |
Prednisone 10 mg per day High-dose ICS Warfarin |
Last blood eosinophil count under treatment per mm3 |
290 |
330 |
300 |