摘要
一些研究已经发现了罕见的pi等位基因与哮喘或支气管高反应性(BHR)之间的联系。本研究探讨了pi型对生活在丹麦农村地区的2308名青年BHR的影响,他们的平均±SD年龄为19.7±2.4岁。访谈、肺功能测试、支气管组胺激发及皮肤点刺试验。测定血清α -抗胰蛋白酶水平,采用等电聚焦法分型,分为4组:1)MM组和MX组;2)女士;3) MZ;农户对室内尘螨的敏感性呈显著正增长趋势,MM组为12%,而少见pi组为22%。在一项医生诊断哮喘的单侧测试中,pi组内趋势检测呈阳性,在罕见的pi组中,这些症状的吸烟者中,这些症状的峰值患病率为40%。在多元logistic回归分析中,发现具有稀有pi等位基因的农业学校服务员BHR的比值比(OR)增加。MS的OR(95%可信区间)为1.71 (0.84-3.49),MZ为1.93(1.10-3.39),罕见pi组为4.34(1.19-15.8)。 Such a relationship was not found among the conscripts. These results show that a gene/environment interaction may exist between the farming occupation and the rare Pi-alleles, leading to a higher proportion of bronchial hyperresponsiveness related to the rare Pi-alleles in farming school attendants, in contrast to what is found among other young people living in rural areas.