抽象的
细胞免疫在呼吸道合胞病毒(RSV)支气管炎中的疾病严重程度的作用在很大程度上是未知的。本研究调查了住院通风和非透明的RSV支气管炎患者疾病严重程度和全身细胞因子反应之间的关联。在用Phytohaemagglutinin(PHA)刺激的全血培养中,测定了急性疾病期间的淋巴抑制反应和干扰素(IFN)-γ和白细胞介素(IL)-4产生。此外,测量血浆细胞因子。在入院后3-4周的临时阶段重复测量。包括五十名患者。呼吸患者中位年龄明显低于非透明患者(1与4个月,P <0.05)。与非透明的患者相比,通风患者淋巴抑制性反应显着降低了IFN-Gamma和IL-4的较低。事实上,通风患者的IFN-GAMMA和IL-4生产几乎完全无法察觉。通风患者的血浆IL-8水平显着高于非透明患者。 In the convalescent phase, lymphoproliferative and cytokine responses as well as plasma IL-8 levels were normal in both patient groups. Since RSV bronchiolitis is associated with the subsequent development of asthma, the possible skewing of the T-helper (Th1/Th2) cytokine balance was investigated. This was found neither in the acute nor in the convalescent phase. In conclusion, the data indicate that depressed lymphocyte function and elevated plasma interleukin-8 levels are markers of severe disease. It is suggested that age and maturation related immune mechanisms could explain the occurrence of severe respiratory syncytial virus bronchiolitis requiring mechanical ventilation in young infants.