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391.011 624.189 0.51 -264.983 re
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BT
/F1 1 Tf
14.944 0 0 14.944 72.17 715.351 Tm
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5.2505 -1.0319 TD
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[(respiratory)-333.8(syncytial)-331.6(v)0.1(irus)-330(bronchiolitis)]TJ
/F2 1 Tf
10.959 0 0 10.959 71.603 662.57 Tm
0 Tc
[(L.)-336.1(Bont)]TJ
/F3 1 Tf
3.2177 0 TD
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(*)Tj
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0.4966 0 TD
[(,)-334.6(C.J.)-330.7(Heijnen)]TJ
/F3 1 Tf
6.0888 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(A)0(.)-330.8(Kavelaars)]TJ
/F3 1 Tf
6.3164 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
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/F3 1 Tf
8.219 0 0 7.305 370.885 667.445 Tm
(#)Tj
/F2 1 Tf
10.959 0 0 10.959 375.024 662.57 Tm
[(,)-329.4(F)0(.)-336.2(Brus)]TJ
/F4 1 Tf
8.219 0 0 7.305 417.657 667.445 Tm
(1)Tj
/F2 1 Tf
10.959 0 0 10.959 421.852 662.57 Tm
[(,)-334.6(J.Th.M.)-325.8(Draaisma)]TJ
/F3 1 Tf
8.219 0 0 7.305 515.452 667.445 Tm
(+)Tj
/F2 1 Tf
10.959 0 0 10.959 520.044 662.57 Tm
(,)Tj
-30.8787 -1.0243 TD
[(S.M.)-334.2(Geelen)]TJ
/F3 1 Tf
5.5974 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-329.4(H.J.)-335.8(van)-330.8(Vught)]TJ
/F3 1 Tf
7.258 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-334.6(J.L.L.)-331(Kimpen)]TJ
/F3 1 Tf
6.7613 0 TD
(*)Tj
/F5 1 Tf
8.966 0 0 8.966 58.28 614.721 Tm
[(Peripheral)-409.7(blood)-410.8(cytokine)-417.1(r)30.9(esponses)-410(and)-409.5(disease)-411.7(severity)-413.2(in)-412.4(r)30.9(espiratory)-413.8(syncytial)-414.1(virus)]TJ
0 -1.0559 TD
[(br)31.4(onchiolitis.)-313.7(L.)-304.5(Bont,)-310.2(C.J.)-306.5(Heijnen,)-310.4(A.)-303.1(Kavelaars,)-310.8(W)82.2(.M.C)-307.2(van)-308.1(Aalder)27.8(en,)-305.2(F)123.5(.)-306.4(Brus,)-303.9(J.Th.M.)]TJ
T*
[(Draaisma,)-332.6(S.M.)-334(Geelen,)-340(H.J.)-330.3(van)-333.4(V)72.9(ught,)-332(J.L.L.)-332.9(Kimpen.)]TJ
/F6 1 Tf
23.047 0 TD
(#)Tj
/F5 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-328.2(1999.)]TJ
/F7 1 Tf
-24.046 -1.0496 TD
[(ABSTRACT)66.7(:)-228.1(The)-229.2(r)13.4(ole)-228.3(of)-227.6(cellular)-234.9(immunity)-233.7(in)-227.6(disease)-227(severity)-233.7(in)-227.6(r)13.4(espiratory)-231.3(syncytial)]TJ
0 -1.0622 TD
[(virus)-296.6(\(RSV\))-295.4(bronc)12.2(hiolitis)-297.1(is)-293.4(largely)-297.9(unknown.)-292.7(This)-295.7(study)-294(investigated)-295.7(the)-295(association)]TJ
0 -1.0559 TD
[(between)-382.9(disease)-385(severity)-385.5(and)-387.7(systemic)-381(cytokine)-388(r)13.4(esponses)-388.2(in)-379.3(hospitalized)-390.5(ventilated)]TJ
T*
[(and)-330.8(nonventilated)-341.7(RSV)-332.4(bronc)12.2(hiolitis)-341.3(patients.)]TJ
0.999 -1.0559 TD
[(In)-314.9(whole)-317.6(blood)-313.2(culture)10.1(s)-316.8(stimulated)-316.3(with)-313(phytohaemagglutinin)-319.9(\(PHA\),)-314.4(lymphopro-)]TJ
-0.999 -1.0559 TD
[(liferative)-319.5(r)13.4(esponses)-318.7(and)-311.8(interfer)8.4(on)-313.7(\(IFN\)-)]TJ
/F8 1 Tf
17.622 0 TD
(c)Tj
/F7 1 Tf
0.8157 0 TD
[(and)-311.8(interleukin)-318.6(\(IL\)-4)-315.6(production)-308.3(during)]TJ
-18.4376 -1.0559 TD
[(acute)-413.9(illness)-415.3(were)-405.2(measured.)-407.9(In)-409.8(addition,)-417.6(plasma)-416.9(cytokines)-414(wer)11.3(e)-416.6(measure)10.3(d.)-412(Meas-)]TJ
T*
[(ureme)10.5(nts)-334.3(were)-329.4(r)13.4(epeated)-335.3(in)-335.1(the)-332.9(convalescent)-336.1(phase,)-333.6(3\2614)-333.6(weeks)-335.2(after)-334(admission.)]TJ
0.999 -1.0559 TD
[(Fifty)-226.6(patients)-232.3(wer)11.3(e)-226.9(included.)-225.1(The)-229.2(median)-224.3(age)-225.9(in)-227.6(ventilaled)-227.4(patients)-226(was)-224.3(significantly)]TJ
-0.999 -1.0559 TD
[(lower)-274.6(than)-280.6(in)-271.8(nonventilated)-278.5(patients)-276.6(\(1)]TJ
/F9 1 Tf
16.6988 0 TD
(versus)Tj
/F7 1 Tf
2.858 0 TD
[(4)-271.4(months,)-277.8(p)]TJ
/F10 1 Tf
4.9888 0 TD
(<)Tj
/F7 1 Tf
0.5501 0 TD
[(0.05\).)-276.6(In)-270.7(comparison)-280.2(with)]TJ
-25.0956 -1.0622 TD
[(nonventilated)-398.6(patients,)-393.3(the)-396.1(ventilated)-396.7(patients)-403(had)-387.7(significantly)-401.3(lower)-394.7(lymphoproli-)]TJ
0 -1.0559 TD
[(ferative)-271.4(r)13.4(esponses)-268.1(and)-267.5(a)-265.1(lower)-261.9(production)-257.7(of)-265.5(IFN-)]TJ
/F8 1 Tf
21.1375 0 TD
(c)Tj
/F7 1 Tf
0.7651 0 TD
[(and)-261.2(IL-4.)-267(In)-270.7(fact,)-261.8(IFN-)]TJ
/F8 1 Tf
9.5919 0 TD
(c)Tj
/F7 1 Tf
0.7651 0 TD
[(and)-261.2(IL-4)]TJ
-32.2595 -1.0559 TD
[(production)-377.8(in)-385.7(ventilated)-390.3(patients)-384.1(was)-388.7(almost)-387.6(completely)-384.7(undetectable.)-392.8(Plasma)-383.8(IL-8)]TJ
T*
[(levels)-217.4(in)-221.3(ventilated)-219.6(patients)-219.7(were)-209.2(significantly)-224.3(higher)-217.3(than)-217.4(in)-221.3(nonventilated)-221.6(patients.)-216.2(In)]TJ
T*
[(the)-250.7(convalescent)-253.9(phase,)-251.4(lymphopr)12.1(oliferative)-255.7(and)-248.6(cytokine)-255.2(r)13.4(esponses)-249.1(as)-253.1(well)-252.4(as)-246.8(plasma)]TJ
T*
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0 -1.0622 TD
[(with)-433.2(the)-434.1(subsequent)-433.3(development)-435.8(of)-429.9(asthma,)-431(the)-434.1(possible)-436.3(skewing)-430.2(of)-436.2(the)-427.8(T)78(-helper)]TJ
0 -1.0559 TD
[(\(Th1/Th2\))-259.2(cytokine)-261.5(balance)-254.8(was)-255.9(investigated.)-260.6(This)-257.8(was)-262.2(found)-253.4(neither)-261.8(in)-259.2(the)-257(acute)-255.8(nor)]TJ
T*
[(in)-335.1(the)-332.9(convalescent)-336.1(phase.)]TJ
0.999 -1.0559 TD
[(In)-352.9(conclusion,)-346.8(the)-351.9(data)-351.6(indicate)-352.4(that)-352.6(depr)11.6(essed)-352.1(lymphocyte)-349.5(function)-356.2(and)-349.7(elevated)]TJ
-0.999 -1.0559 TD
[(plasma)-265.1(interleukin-8)-268(levels)-261.7(are)-257.3(markers)-261.5(of)-265.5(severe)-250.1(disease.)-267.8(It)-260.4(is)-268.1(suggested)-261(that)-264(age)-263.8(and)]TJ
T*
[(maturation)-540.4(related)-528.8(immune)-540.9(mechanisms)-541(could)-540.6(explain)-535.6(the)-541.6(occurrence)-527.9(of)-543.7(sever)14.7(e)]TJ
T*
[(respirator)9.2(y)-416.8(syncytial)-418(virus)-416.7(bronchiolitis)-411.3(requiring)-412.6(mechanical)-420.2(ventilation)-417.7(in)-417.3(young)]TJ
0 -1.0622 TD
(infants.)Tj
/F5 1 Tf
0 -1.0496 TD
[(Eur)-331.9(Respir)-333.8(J)-334.4(1999;)-333.5(14:)-334.6(144\261149.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 615.742 Tm
[(*Universi)11.3(ty)-695.3(Hospital)-683(for)-691.2(Children)-688.9(and)]TJ
0 -1.0599 TD
[(Y)92(outh)-769.3("Het)-772.3(W)33.6(ilhelmina)-771.3(Kinderzieken-)]TJ
0 -1.067 TD
[(huis",)-441.7(Utrecht,)]TJ
5.977 0 0 5.313 452.466 602.362 Tm
(#)Tj
7.97 0 0 7.97 455.471 598.79 Tm
[(Academic)-439.5(Medical)-434.2(Cen-)]TJ
-6.7717 -1.0599 TD
[(ter)33.2(,)-866.8(Amsterdam,)]TJ
/F4 1 Tf
5.977 0 0 5.313 463.918 593.858 Tm
(1)Tj
/F3 1 Tf
7.97 0 0 7.97 466.923 590.343 Tm
[(Dept)-863.3(of)-870.9(Pediatric)9.7(s,)]TJ
-8.2086 -1.067 TD
[(Elisabeth)-374.2(Hospital,)-376.1(T)34.9(ilbur)12.7(g,)]TJ
5.977 0 0 5.313 493.738 585.411 Tm
(+)Tj
7.97 0 0 7.97 497.083 581.839 Tm
[(Dept)-379.6(of)-380.1(Pe-)]TJ
-11.9927 -1.0599 TD
[(diatrics,)-465.2(Rijnstate)-471.1(Hospital,)-461.4(Arnhem,)-464.8(the)]TJ
T*
[(Netherlands)10.4(.)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-333.4(J.L.L.)-324.3(Kimpen)]TJ
0 -1.0599 TD
[(Dept)-329.8(of)-330.3(Pediatric)-324.6(Infectious)-331.8(Disease)10.5(s)]TJ
0 -1.067 TD
[(University)-237.9(Hospital)-242(for)-243(children)-242.2(and)-241.6(youth)]TJ
0 -1.0599 TD
[("Het)-331.3(W)33.6(ilhelmina)-323.2(Kinderziecke)8.6(nhuis")]TJ
0 -1.067 TD
[(POB)-325.9(18009)]TJ
0 -1.0599 TD
[(3501)-325.9(CA)-330.2(Utrecht)]TJ
T*
[(The)-329.7(Netherlands)]TJ
0 -1.067 TD
[(Fax:)-325.1(31)-330.1(0302320707)]TJ
0 -2.1197 TD
[(Keywords)11.5(:)-334.6(Cytokines)]TJ
0 -1.067 TD
[(disease)-328.4(severity)]TJ
0 -1.0599 TD
[(respiratory)-322.8(syncytial)-328.8(virus)]TJ
0 -2.1268 TD
[(Received:)-327.9(Decemb)12.9(er)-336.4(9)-332.2(1998)]TJ
0 -1.0599 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(May)-326.1(18)-330.1(1999)]TJ
0 -2.1268 TD
[(This)-254(study)-249.2(was)-259.6(funded)-249.7(by)-251.9(the)-258.3(Dutch)-249.5(Asth-)]TJ
0 -1.0599 TD
[(ma)-329.4(Foundation)-321.9(\(grant)-330.5(No.)-331.6(32.96.08)14.7(\))]TJ
9.963 0 0 9.963 68.258 333.014 Tm
[(Re)16.1(sp)20(ir)17.3(at)12.8(or)19.6(y)-199.9(s)0(y)20(n)0(c)15.1(y)0(t)18.9(i)0(a)18.4(l)-202.3(vi)18.9(ru)19.6(s)-201.1(\()0(R)20.6(S)0(V)12.4(\))-195.8(br)14(on)21.2(ch)15.1(io)18.9(li)16.5(ti)16.5(s)-195.4(a)0(c)14.7(c)0(o)20.8(u)0(n)15.5(t)0(s)]TJ
-1.0015 -1.0584 TD
[(fo)19.6(r)-520.2(a)-519(co)15.1(ns)20(id)18.9(er)13.5(ab)20.8(le)-510.8(nu)15.5(mb)18.1(er)-510(of)-509.6(pa)20.8(ed)15.1(ia)18.4(tr)17.3(ic)-510.8(in)18.9(te)18.4(ns)14.4(iv)18.8(e)-519(c)0(a)14.7(r)0(e)]TJ
0 -1.0527 TD
[(ad)15.1(mi)21.4(ss)13.2(io)18.9(ns)-395.4(du)15.5(ri)17.3(ng)-394.2(ye)15.1(ar)19.2(ly)-396.6(wi)14.9(nt)18.9(er)-396.2(ep)15.1(id)18.9(em)17.7(ic)12.8(s.)-395(Ri)14.1(sk)-395.4(fa)19.2(ct)18.4(or)13.9(s)]TJ
T*
[(pr)19.6(ed)15.1(ic)18.4(ti)16.5(ng)-286.1(a)-302.8(c)0(o)20.8(m)0(p)18.1(l)0(i)16.5(c)0(a)14.7(t)0(e)18.4(d)-296.7(co)15.1(ur)19.6(se)-287.7(in)-288.4(RS)17.3(V)-300.6(l)0(o)18.9(w)0(e)16.9(r)-298.3(re)13.5(sp)20(ir)17.3(at)18.4(or)13.9(y)]TJ
T*
[(tr)17.3(ac)14.7(t)-401.5(i)13.9(ll)16.5(ne)15.1(ss)18.9(,)-398.7(e)0(v)15.1(e)0(n)20.8(t)0(u)13.2(a)0(l)18.5(l)0(y)-390.9(n)0(e)15.1(c)0(e)20.4(s)0(s)18.9(i)0(t)16.5(a)0(t)18.4(i)0(n)13.2(g)-399.1(ve)20.8(nt)13.2(il)16.5(at)18.4(or)19.6(y)-399.1(s)0(u)14.4(p)0(p)21.2(o)0(r)13.9(t)0(,)]TJ
0 -1.0584 TD
[(in)18.9(cl)18.4(ud)15.5(e)-200.3(c)0(o)20.8(n)0(g)15.5(e)0(n)20.8(i)0(t)16.5(a)0(l)-192.1(h)0(e)15.1(a)0(r)19.2(t)-202.3(di)18.9(se)19.6(as)19.6(e,)-195(pr)19.6(em)17.7(at)18.4(ur)14(it)16.5(y)73.2(,)-199.6(ag)20.8(e)]TJ
/F10 1 Tf
19.1146 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
0.1942 Tc
[(6w)194.2(e)211.1(e)194.2(k)209.3(s)]TJ
-19.6608 -1.0527 TD
0 Tc
[(an)15.1(d)-319.4(c)0(h)15.1(r)0(o)19.6(n)0(i)13.2(c)-319.8(lu)13.2(ng)-314.5(di)18.9(se)19.6(as)13.9(e)-319.8([)0(1)13.9(\2613].)]TJ
1.0015 -1.0471 TD
[(Al)14.9(th)18.9(ou)15.5(gh)-530.8(kn)21.2(ow)11.6(l)13.9(e)0(d)15.1(g)0(e)-531.2(o)0(f)-532.3(t)0(h)13.2(e)-541.8(im)15.7(mu)18.1(no)21.2(pa)15.1(th)18.9(og)15.5(en)20.8(es)13.9(is)-534.3(of)]TJ
-1.0015 -1.0584 TD
-0.0161 Tc
[(R)-16.1(S)1.2(V)-441.9(b)-16.1(ro)-16.1(nc)-16.1(h)4.7(i)-16.1(ol)-16.1(i)6.1(t)-16.1(is)-439.2(h)-16.1(a)-1(s)-439.2(i)-16.1(mp)-16.1(ro)-16.1(ve)-16.1(d)-427.8(o)-16.1(ve)-16.1(r)-429.3(p)-16.1(re)-16.1(v)4.7(i)-16.1(ou)-16.1(s)-434.2(d)-16.1(e)4.7(c)-16.1(ad)-16.1(es)-16.1(,)]TJ
0 -1.0527 TD
0 Tc
[(li)16.5(tt)16.5(le)-345.7(is)-346.5(kn)21.2(ow)17.3(n)-353.6(a)0(b)15.1(o)0(u)21.2(t)-356(th)18.9(e)-354(a)0(s)13.9(s)0(o)20(c)0(i)18.4(a)0(t)12.8(i)0(o)18.9(n)-353.6(be)15.1(t)13.9(w)0(e)11.2(e)0(n)-343.4(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(l)13.9(o-)]TJ
T*
[(gi)18.9(ca)14.7(l)-202.3(p)0(a)15.1(r)0(a)19.2(m)0(e)17.7(t)0(e)12.8(r)0(s)-192.1(a)0(n)15.1(d)-205.6(di)18.9(se)19.6(as)13.9(e)-200.3(s)0(e)13.9(v)0(e)20.8(r)0(i)17.3(t)0(y)-197.4([)0(4)19.6(,)-216.6(5].)-214.1(T)57.7(o)-211.3(the)-221.3(authors)]TJ
/F11 1 Tf
22.5801 0 TD
(')Tj
/F3 1 Tf
-22.5801 -1.0528 TD
[(know)-7(ledge,)-502.5(RSV)75.2(-specific)-512.3(immunog)-8.3(lobulin)-507.6(\(Ig\)E)-507.8(titres,)]TJ
0 -1.0584 TD
[(histami)-11.5(ne)-280.8(relea)-9(se)-282(and)-281.5(eosino)-8.6(phil)-281(cati)-8.6(onic)-279(p)-6.5(rotein)-284.5(titres)-288.1(in)]TJ
0 -1.0527 TD
[(respirato)-11.1(ry)-247.8(secretions)-250.9(and)-247.4(eosin)-7.8(ophil)-247.6(blood)-245.2(counts)-247.6(are)-249.4(the)]TJ
T*
[(only)-352.6(immunolog)-12.2(ical)-350.1(phenom)-8.1(ena)-344.5(associ)-10.1(ated)-347.7(wi)-7.8(th)-345.3(disea)-8.2(se)]TJ
T*
[(severi)-10.6(ty)-334([6,)-333.6(7].)]TJ
1.0015 -1.0527 TD
[(Ce)16.1(ll)16.5(ul)18.9(ar)-384.8(im)15.7(m)13.2(u)0(n)15.5(i)0(t)16.5(y)-387.7(is)-386.4(th)18.9(e)-388.1(c)0(l)18.4(a)0(s)13.9(s)0(i)17.7(c)0(a)20.4(l)-395.8(de)20.8(fe)13.5(nc)20.8(e)-393.8(m)0(e)17.7(c)0(h)20.8(a)0(n)15.1(i)0(s)17.7(m)]TJ
-1.0015 -1.0528 TD
[(ag)15.1(ai)18.5(ns)20(t)-338.9(v)0(i)18.9(r)0(a)13.5(l)-338.9(in)18.9(fe)19.2(ct)12.8(i)13.9(o)0(n)15.5(s)0(.)-326.7(H)0(o)11.6(w)12.4(ev)15.1(er)47.7(,)-336.1(t)0(h)18.9(e)-342.6(ro)19.6(le)-328.7(of)-333.2(ce)20.4(ll)16.5(ul)18.9(ar)-333.6(im)15.7(-)]TJ
T*
[(mu)18.1(ni)18.9(ty)-214.5(in)-208.8(th)18.9(e)-217.4(i)0(m)15.7(m)0(u)18.1(n)0(o)15.5(p)0(a)15.1(t)13.9(ho)15.5(ge)15.1(ne)20.8(si)17.7(s)-218.2(o)0(f)-213.7(R)11.6(SV)-209.5(br)14(on)21.2(ch)15.1(io)18.9(li)16.5(ti)16.5(s)-218.2(i)0(s)]TJ
0 -1.0584 TD
[(un)15.5(cl)18.4(ea)20.4(r)60.2(.)-461.3(In)-452.7(mu)12.4(ri)17.3(ne)-451.5(mo)18.1(de)15.1(ls)17.7(,)-461.3(c)0(y)20.8(t)0(o)18.9(t)0(o)13.2(x)0(i)18.9(c)-462.1(T)91.9(-)0(c)19.2(e)0(l)18.4(l)0(s)-454.7(h)0(a)15.1(v)0(e)-451.5(b)0(e)20.8(e)0(n)]TJ
0 -1.0527 TD
[(as)19.6(so)14.3(ci)18.4(at)18.4(ed)-275.1(wi)14.9(th)-277.1(bo)21.2(th)-277.1(cl)18.5(ea)14.7(ra)19.2(nc)15.1(e)-280(o)0(f)-276.3(t)0(h)18.9(e)-285.7(vi)18.9(ru)13.9(s)-280.8(f)0(r)18(o)0(m)-277.8(t)0(h)18.9(e)-285.7(lu)18.9(ng)15.5(s)]TJ
T*
[(an)15.1(d)-302.4(a)0(u)15.1(g)0(m)18.1(e)0(n)15.1(t)0(a)18.4(t)0(i)16.5(o)0(n)-297.4(o)0(f)-299(l)0(u)18.9(n)0(g)-297.4(p)0(a)15.1(t)0(h)18.9(o)0(l)18.9(o)0(g)15.5(y)-302.4([8)13.9(,)-313.4(9].)-322.2(Other)-325.1(studies)]TJ
25.1977 22.1305 TD
[(hav)-8.4(e)-410.9(sugges)-7.4(ted)-414.8(that)-412.2(CD4)-420.7(cells)-414.6(are)-414.4(requi)-8.2(red)-414(for)-415.2(the)-414.8(de-)]TJ
0 -1.0584 TD
[(velopm)-10.5(ent)-511.5(of)-509.6(immune)-514.4(mediated)-516(lung)-511.9(disease)-512.1(in)-510.4(RSV)]TJ
0 -1.0527 TD
[(infec)-8.6(ted)-494.5(BALB/c)-497.2(mice)-493.1([10].)-496(In)-486.8(the)-494.5(human)-496.8(popula)-7.4(tion)]TJ
T*
[(eve)-8.8(n)-359.3(less)-372.4(is)-363.6(know)-7(n)-365(about)-370.8(cellular)-368.9(imm)-11(unity)-367.1(in)-368.1(RSV)-311.8(in-)]TJ
T*
[(fecti)-11(on)-331.6(than)-341.6(in)-334(animal)-343.3(models.)]TJ
1.0015 -1.0527 TD
[(V)57.9(i)0(r)17.3(u)0(s)14.4(-)0(s)18.4(p)0(e)20.8(c)0(i)18.4(f)0(i)11.6(c)-519(cy)15.1(to)18.9(to)18.9(xi)18.9(ci)12.8(t)13.9(y)-524.3(ha)15.1(s)-519.8(b)0(e)15.1(e)0(n)-514.1(d)0(e)20.8(m)0(o)12.4(n)0(s)20(t)0(r)17.3(a)0(t)18.5(e)0(d)-514.1(i)0(n)]TJ
-1.0015 -1.0528 TD
[(pr)13.9(im)15.7(ar)19.2(y)-319.4(a)0(c)14.7(u)0(t)18.9(e)-319.8(in)18.8(fe)19.2(ct)12.8(i)13.9(o)0(n)15.5(s)-320.6(an)20.8(d)-319.4(a)0(p)15.1(p)0(e)20.8(a)0(r)13.5(e)0(d)-309.2(t)0(o)-311.2(b)0(e)-309.2(a)0(n)-309.2(i)0(m)15.7(p)0(o)15.5(r)0(t)17.3(a)0(n)20.8(t)]TJ
T*
[(pa)15.1(ra)19.2(me)12(te)18.4(r)-281.2(i)0(n)-271.4(r)0(e)19.2(c)0(o)15.1(v)0(e)20.8(r)0(y)-270.6([)0(1)48.1(1].)-282.3(Furthe)-8.2(rmor)-9.4(e,)-286.1(it)-296.5(has)-288.4(been)-294.1(sug-)]TJ
0 -1.0584 TD
[(geste)-8.2(d)-581.2(that)-588.6(in)-584.3(RSV)75.2(-infected)-590.8(pati)-8.2(ents)-587.5(with)-586.5(lower)-586.9(res-)]TJ
0 -1.0527 TD
[(pirat)-10.6(ory)-453.4(tract)-454.8(symp)-7.4(toms,)-454(lym)-7.8(phoprolife)-10.3(rative)-455.6(respon)-7.8(ses)]TJ
T*
[(to)-356.7(phytohae)-9.3(magglutinin)-362.9(\(PHA\))-355.5(are)-351.8(d)-6.5(epressed,)-358.8(as)-350.2(are)-351.8(in-)]TJ
T*
[(terl)-9.8(eukin)-228.5(\(IL\)-4,)-237.4(inte)-8.2(rferon)-231.7(\(IFN)-9.4(\)-)]TJ
/F10 1 Tf
13.3102 0 TD
(a)Tj
/F3 1 Tf
0.865 0 TD
[(and)-230.3(IFN-)]TJ
/F8 1 Tf
3.5907 0 TD
(c)Tj
/F3 1 Tf
0.7284 0 TD
(production)Tj
/F5 1 Tf
-18.4943 -1.0584 TD
[(in)-385.2(vitr)30.4(o)]TJ
/F3 1 Tf
3.3688 0 TD
[([12\26114])-8.5(.)-376(I)0(n)-378.7(p)0(a)-7.6(rticular)22.6(,)-376(these)-383.8(dep)-8.4(ressed)-384.9(lympho-)]TJ
-3.3688 -1.0527 TD
[(cyte)-302.2(functions)-305(suggest)-300.7(that)-298.4(suboptim)-9.5(al)-294.5(cellular)-300.6(imm)-11(unity)]TJ
T*
[(mig)-7.8(ht)-504.7(play)-506.6(a)-501.9(role)-508.2(in)-504.7(the)-511.5(outcome)-512.4(of)-503.9(RSV)-454(infec)-8.6(tions.)]TJ
T*
[(How)-10.2(ever)28.7(,)-319.1(thus)-325.3(far)-324.6(no)-320.2(associ)-10.1(ation)-327.7(has)-322.6(been)-322.5(demon)-7.4(strated)]TJ
0 -1.0584 TD
[(betw)-9.8(een)-543.7(cell-med)-11.1(iated)-544.3(immune)-548.6(respon)-7.8(ses)-545.7(and)-543.3(disease)]TJ
0 -1.0527 TD
[(severi)-10.6(ty)58.7(.)]TJ
1.0015 -1.0471 TD
[(RS)11.6(V)-414.4(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(o)18.9(l)0(i)16.5(t)0(i)16.5(s)-417.4(ha)15.1(s)-417.4(b)0(e)20.8(e)0(n)-411.7(r)0(e)19.2(l)0(a)12.8(t)0(e)18.5(d)-416.2(to)-413.6(th)18.9(e)-416.6(s)0(u)14.4(b)0(s)20(e)0(q)15.1(u)0(e)20.8(n)0(t)]TJ
-1.0015 -1.0584 TD
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6.974 0 0 6.974 433.417 133.512 Tm
0.0001 Tc
[(ELL)-8.8(IVER)]TJ
9.963 0 0 9.963 464.938 133.512 Tm
0 Tc
[(and)-270.2(coworkers)-277.7([6,)]TJ
-15.6206 -1.0527 TD
[(16])-567.3(showed)-567.8(that)-565.9(RSV)-562.1(can)-566.5(induce)-565.4(virus-spec)-10.7(ific)-567.5(IgE,)]TJ
T*
[(whi)-8.6(ch)-525.5(correl)-11(ates)-531(with)-529.6(recurr)-10.2(ent)-528.6(episo)-7.8(des)-527.4(of)-532.3(wheezing)]TJ
/F2 1 Tf
6.974 0 0 6.974 58.28 797.499 Tm
0.0001 Tc
[(Eur)-334.8(Respir)-337.8(J)-337.2(1999;)-339.7(14:)-330.1(144\261149)]TJ
0 -1.1462 TD
0 Tc
[(Printed)-341.4(i)0(n)-335.6(U)-0.1(K)-331.2(\261)-334.1(all)-337(rights)-335.9(r)0(e)-9.2(s)0(erved)]TJ
52.703 2.2844 TD
0.0001 Tc
(Copyright)Tj
/F6 1 Tf
5.928 0 0 5.928 457.909 806.456 Tm
0 Tc
(#)Tj
/F2 1 Tf
6.974 0 0 6.974 463.805 805.436 Tm
0.0001 Tc
[(ERS)-339.8(Journals)-337.8(L)0(td)-338.3(1999)]TJ
-4.4305 -1.1381 TD
[(European)-338.6(Res)-10.1(piratory)-336.9(Journal)]TJ
3.2843 -1.1462 TD
[(ISSN)-335.2(0903-1936)]TJ
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0 -1.0471 TD
[(subje)-7.8(cts)-364.8(with)-370.2(asthma)-370.6(have)-368.1(incre)-8.6(ased)-363.6(relea)-9(se)-367.3(of)-361.6(T)80.5(-help)-8.2(er)]TJ
0 -1.0528 TD
[(\(Th\)2)-318.4(cytoki)-9.7(nes,)-317.2(including)-321.7(IL)-7.2(-4,)-316.5(and)-315.7(norm)-7.8(al)-311.6(or)-316.1(low)-321.6(pro-)]TJ
0 -1.0471 TD
[(ductio)-9.7(n)-325.1(o)0(f)-327.5(the)-335.1(Th1)-325.1(cy)-7.6(tokine)-328.4(IF)-8(N-)]TJ
/F8 1 Tf
13.6061 0 TD
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(c)Tj
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[(ratios)-314.1(have)-311.2(also)-308.6(be)-7.6(en)-309.2(mentioned)-317.2(in)-311.2(RSV)-260.5(infection)]TJ
-2.7315 -1.0471 TD
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0 -1.0528 TD
[(infec)-8.6(tion)-224.1(and)-224.6(the)-221.3(subseq)-7.4(uent)-222.1(develo)-7.8(pment)-226(of)-225.1(asthma)-228.3([13].)]TJ
1.0015 -1.0471 TD
[(Th)17.1(is)-306.7(st)12(ud)21.2(y)-319.4(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(e)0(d)-309.2(l)0(y)18.9(m)0(p)18.1(h)0(o)15.5(p)0(r)19.6(o)0(l)13.2(i)13.9(fe)13.5(ra)19.2(ti)16.5(ve)-309.2(an)15.1(d)-313.7(c)0(y)15.1(t)0(o)18.9(k)0(i)18.9(n)0(e)]TJ
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T*
[(te)18.4(d)-222.7(w)0(i)14.9(t)0(h)-214.5(R)11.6(SV)-215.2(br)13.9(on)21.2(ch)15.1(io)18.9(li)16.5(ti)16.5(s)-218.2(i)0(n)-214.5(o)0(r)14(d)0(e)20.8(r)-224.3(to)-214.5(de)20.8(te)12.8(rm)16.5(in)18.9(e)-223.1(a)-223.1(p)0(o)21.2(s)0(s)18.9(i)0(b)13.2(l)0(e)]TJ
0 -1.0471 TD
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0 -1.0528 TD
[(th)18.9(e)-331.2(p)0(o)15.5(s)0(s)18.9(i)0(b)18.9(l)0(e)-328.7(s)0(k)20(e)0(w)16.9(i)0(n)18.9(g)-336.5(of)-321.8(th)18.9(e)-331.2(T)0(h)17.1(1)0(/)18.9(T)0(h)17.1(2)-336.5(cy)20.8(to)18.9(ki)13.2(ne)-320.6(ba)15.1(la)18.4(nc)20.8(e)-336.9(i)0(n)]TJ
0 -1.0471 TD
[(th)18.9(e)-325.5(c)0(o)15.1(u)0(r)19.6(s)0(e)-316.1(o)0(f)-316.1(t)0(h)18.9(e)-325.5(di)18.9(se)19.6(as)13.9(e)-325.5(w)12.4(as)-316.1(in)18.9(ve)15.1(st)17.7(ig)18.9(at)18.4(ed)15.1(.)]TJ
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9.5544 -2.4355 TD
(Methods)Tj
/F5 1 Tf
-9.5544 -1.6503 TD
[(Select)-10.6(ion)-334.7(of)-334(patien)-9.7(ts)]TJ
/F3 1 Tf
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-1.0015 -1.0527 TD
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[(he)15.1(m\))16.5(.)-478.4(I)0(n)19.6(c)0(l)18.4(u)0(s)14.4(i)0(o)18.9(n)-478.8(cr)19.2(it)16.5(er)19.2(ia)-470.9(we)16.9(re)-475.8(ho)21.2(sp)14.4(i)13.9(t)0(a)12.8(l)-475.5(ad)15.1(mi)15.7(ss)18.9(io)18.9(n,)-473.5(l)13.9(o)0(w)11.6(e)0(r)]TJ
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/F10 1 Tf
12.8663 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(13)-337.3(mo)18.1(nt)18.9(hs)-332.8(an)15.1(d)-342.2(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)]TJ
-13.4069 -1.0471 TD
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[(ne)15.1(ed)-201.1(fo)13.9(r)-212.9(m)0(e)17.7(c)0(h)15.1(a)0(n)20.8(i)0(c)18.4(a)0(l)-209.2(v)0(e)20.8(n)0(t)13.2(i)0(l)22.2(a)0(t)12.8(i)0(o)18.9(n)0(.)-206(C)11.6(on)15.5(tr)17.3(ol)-203.1(ch)15.1(il)16.5(dr)19.6(en)-206.8(ag)20.8(ed)]TJ
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[(cl)18.4(ud)15.5(ed)-235.2(we)16.9(re)-236.8(in)18.9(fa)19.2(nt)13.2(s)-241(p)0(r)13.9(i)0(o)18.9(r)-241.4(to)-237.2(mi)15.7(no)15.5(r)-241.4(s)0(u)14.4(r)20.4(ge)20.8(ry)76.5(,)-245.1(p)0(r)19.6(i)0(o)18.9(r)-247.1(to)-237.2(ca)20.4(rd)19.6(ia)12.8(c)]TJ
0 -1.0471 TD
[(su)20(r)14.7(g)0(e)20.8(r)0(y)-498.2(i)0(n)-499(t)0(h)18.9(e)-501.9(ab)15.1(se)19.6(nc)15.1(e)-507.6(o)0(f)-492.5(h)0(a)15.1(e)0(m)17.7(o)0(d)15.5(y)0(n)21.2(a)0(m)12(i)0(c)-493.7(c)0(o)15.1(m)0(p)18.1(r)0(o)19.6(m)0(i)15.7(s)0(e)13.9(,)]TJ
0 -1.0527 TD
[(he)15.1(al)18.5(th)18.8(y)-285.3(p)0(r)19.6(e)0(m)17.7(a)0(t)12.8(u)0(r)19.6(e)0(l)18.5(y)-285.3(bo)21.2(rn)-276.3(in)13.2(fa)19.2(nt)18.9(s,)-275.5(he)15.1(al)18.4(th)18.9(y)-285.3(i)0(n)18.9(f)0(a)19.2(n)0(t)18.9(s)-286.5(sc)19.6(re)13.5(en)20.8(ed)]TJ
0 -1.0471 TD
[(fo)19.6(r)-434.8(c)0(o)15.1(n)0(g)21.2(e)0(n)15.1(i)0(t)16.5(a)0(l)-425.4(d)0(i)18.9(s)0(o)20(r)0(d)13.9(e)0(r)19.2(s)-434.4(an)20.8(d)-433.2(i)0(n)13.2(f)0(a)19.2(n)0(t)18.9(s)-434.4(wi)14.9(th)-425(mi)21.4(ld)-425(an)15.1(ae)20.4(mi)15.7(a.)]TJ
0 -1.0528 TD
[(Th)17.1(is)-420.5(st)17.7(ud)15.5(y)-433.2(w)12.4(as)-424.2(ap)15.1(pr)19.6(ov)15.5(ed)-423(by)-422.6(th)18.9(e)-433.7(M)0(e)18.9(d)0(i)18.9(c)0(a)14.7(l)-429.9(Et)14.7(hi)18.9(ca)14.7(l)-429.9(C)0(o)16.5(m)0(-)]TJ
T*
[(mi)15.7(tt)16.5(ee)-207.2(in)-203.1(al)12.8(l)-213.7(p)0(a)20.8(r)0(t)17.3(i)0(c)12.8(i)0(p)18.9(a)0(t)18.4(i)0(n)18.9(g)-217(ce)20.4(nt)13.2(re)19.2(s)-218.2(a)0(n)20.8(d)-217(pa)20.8(re)13.5(nt)18.9(s)-212.5(o)0(f)-208(a)0(l)18.4(l)-219.4(su)20(bj)18.9(ec)14.7(ts)]TJ
0 -1.0471 TD
[(ga)15.1(ve)-314.9(w)12.4(r)0(i)17.3(t)0(t)16.5(e)0(n)-314.9(i)0(n)13.2(f)0(o)19.6(r)0(m)16.5(e)0(d)-314.9(c)0(o)15.1(n)0(s)20(e)0(n)15.1(t)0(.)]TJ
/F5 1 Tf
0 -2.4356 TD
[(Collec)-9.2(tion)-337.9(of)-334(materi)-9.2(als)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(W)37.9(i)0(t)16.5(h)0(i)18.9(n)-393.4(24)-388.5(h)-393.4(a)0(f)19.2(t)0(e)12.8(r)-395(ad)20.8(mi)15.7(ss)18.9(io)13.2(n,)-382.4(ve)15.1(no)21.2(us)-389.7(or)-384.4(ar)19.2(te)12.8(ri)17.3(al)-385.6(bl)18.9(oo)15.5(d)]TJ
-1.0015 -1.0527 TD
[(wa)16.9(s)-320.6(t)0(a)18.4(k)0(e)15.1(n)-313.7(fr)12.4(om)-306.3(al)12.8(l)-316.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(.)-319.1(F)11.4(r)0(o)13.9(m)-316.9(al)12.8(l)-316.1(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)17.7(,)-319.1(bl)18.9(oo)15.5(d)-319.4(w)0(a)16.9(s)]TJ
0 -1.0471 TD
[(ob)15.5(ta)18.4(in)18.9(ed)-536.8(in)-538.8(t)13.9(u)0(b)15.5(e)0(s)-538(c)0(o)20.8(n)0(t)13.2(a)0(i)18.4(n)0(i)18.9(n)0(g)-536.4(e)0(t)18.4(h)0(y)15.5(l)0(e)18.4(n)0(e)20.8(d)0(i)13.2(a)0(m)17.7(i)0(n)18.9(e)0(t)18.4(e)0(t)12.8(r)0(a)19.2(a)0(c)20.4(e)0(t)12.8(i)0(c)]TJ
0 -1.0528 TD
[(ac)14.7(i)13.9(d)-365(\(E)15.5(DT)87.2(A\))15.7(.)-364.6(T)40.6(ub)21.2(es)-355.9(we)16.9(re)-362(di)18.9(re)19.2(ct)18.4(ly)-356.7(pl)18.9(ac)14.7(ed)-354.7(on)-360(ic)18.4(e,)-354.4(pl)18.9(as)13.9(ma)]TJ
0 -1.0471 TD
[(wa)16.9(s)-309.2(s)0(e)19.6(p)0(a)15.1(r)0(a)19.2(t)0(e)18.4(d)-308.1(an)15.1(d)-302.4(s)0(t)17.7(o)0(r)14(e)0(d)-297.8(a)0(t)-300.2(-)0(7)19.6(0)]TJ
/F11 1 Tf
12.4964 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
[(C.)-301.8(In)-299(ad)20.8(di)13.2(t)13.9(i)0(o)13.2(n)0(,)-297.1(w)0(h)17.3(i)0(t)16.5(e)-308.5(ce)20.4(ll)]TJ
-12.872 -1.0528 TD
[(co)15.1(un)21.2(ts)-306.7(we)16.9(re)-305.1(pe)15.1(rf)18(or)19.6(me)17.7(d)-313.7(\()0(T)78.1(e)0(c)14.7(h)0(n)21.2(i)0(c)12.8(o)0(n)-303.1(H)0(1)17.3(,)-313.4(B)11.6(a)0(y)15.1(e)0(r)-305.1(T)69.1(ec)20.4(hn)15.5(ic)18.4(on)15.5(,)]TJ
0 -1.0471 TD
[(NY)138.6(,)-427.2(U)12.4(SA)12.4(\).)-418.2(F)11.4(r)0(o)19.6(m)-430.7(su)14.4(bj)18.9(ec)20.4(ts)-420.5(in)-419.3(th)18.9(e)-428(W)37.9(il)16.5(he)20.8(lm)15.7(in)18.9(a)-428(C)0(h)16.5(i)0(l)16.5(d)0(r)19.6(e)0(n)]TJ
/F11 1 Tf
22.2045 0 TD
(')Tj
/F3 1 Tf
0.2105 0 TD
(s)Tj
-22.4151 -1.0528 TD
[(Ho)17.3(sp)20(it)16.5(al)12.8(,)-341.8(U)0(t)14.9(r)0(e)19.2(c)0(h)15.1(t)0(,)-339.3(h)0(e)20.8(p)0(a)15.1(r)0(i)17.3(n)0(i)18.9(z)0(e)14.7(d)-342.2(bl)13.2(oo)21.2(d)-347.9(w)0(a)16.9(s)-349.1(t)13.9(a)0(k)15.1(e)0(n)-337.7(s)0(i)17.7(m)0(u)18.1(l)0(t)16.5(a)0(n)15.1(-)]TJ
0 -1.0471 TD
[(eo)15.1(us)20(ly)81.4(.)-575.1(T)0(h)17.1(r)0(e)19.2(e)-575.9(we)16.9(ek)15.1(s)-576.7(l)13.9(at)12.8(er)47.7(,)-569.4(i)0(n)-567.3(t)0(h)18.9(e)-575.9(co)15.1(nv)21.2(al)12.8(es)19.6(ce)14.7(nt)-561.6(ph)15.5(as)19.6(e,)]TJ
0 -1.0527 TD
[(he)15.1(pa)20.8(ri)17.3(ni)18.9(ze)14.7(d)-205.6(b)0(l)18.9(o)0(o)15.5(d)-205.6(an)15.1(d)-205.6(p)0(l)18.9(a)0(s)19.6(m)0(a)-204.2(w)12.4(er)13.5(e)-206(t)0(a)18.4(k)0(e)15.1(n)-205.6(fr)18(om)-198.2(al)12.8(l)-202.3(s)0(u)14.4(b)0(j)18.9(e)0(c)14.7(t)0(s)17.7(.)]TJ
/F5 1 Tf
0 -3.3859 TD
[(Cell)-337.3(cult)-8.2(ur)31.4(es)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(He)16.9(pa)15.1(ri)17.3(ni)18.9(ze)14.7(d)-501.5(b)0(l)18.9(o)0(o)21.2(d)-507.2(\(0)19.6(.5)-490.5(mL)14(\))-503.1(w)0(a)16.9(s)-502.7(di)18.9(lu)18.9(te)18.4(d)-507.2(i)0(n)-493.3(4)0(.)21.6(5)-501.5(mL)]TJ
-1.0015 -1.0527 TD
[(Ro)16.5(sw)16.1(el)18.5(l)-435.6(P)0(a)15.9(r)0(k)-429.9(M)0(e)18.9(m)0(o)12.4(r)0(i)17.3(a)0(l)-425.4(I)0(n)13.9(s)0(t)17.7(i)0(t)16.5(u)0(t)18.9(e)-439.3(\(R)20.6(PM)14.4(I\))-431.5(16)21.2(40)-428.3(me)17.7(di)13.2(um)]TJ
0 -1.0471 TD
[(\(L)15.5(if)17.3(e)-393.8(T)69.1(ec)20.4(hn)15.5(ol)18.9(og)21.2(ie)12.8(s,)-383.6(Gr)15.7(an)20.8(d)-399.1(I)0(s)18.4(l)0(a)18.4(n)0(d)15.5(,)-393(NY)144.3(,)-398.7(U)12.4(SA)12.4(\))-395(a)0(n)20.8(d)-393.4(wh)17.3(ol)13.2(e)]TJ
0 -1.0527 TD
-0.017 Tc
[(b)-17(l)1.9(o)-17(o)-1.5(d)-370.6(c)-17(ul)-17(tu)-17(re)-17(s)-361.6(w)-17(er)-17(e)-362(p)-17(er)-17(fo)-17(rm)-17(ed)-17(.)-359.6(C)-17(ul)-17(tu)-17(re)-17(s)-355.9(w)-17(er)-17(e)-362(p)-17(er)-17(fo)-17(rm)-17(ed)]TJ
0 -1.0471 TD
0 Tc
[(in)-362.4(qu)15.5(ad)20.8(ru)13.9(pl)18.9(ic)18.4(at)18.5(e)-371.1(i)0(n)-368.1(9)0(6)21.2(-)0(w)15.7(e)0(l)18.4(l)-373(cu)15.1(lt)16.5(ur)19.6(e)-371.1(p)0(l)18.9(a)0(t)12.8(e)0(s)-361.6(\()0(N)15.7(u)0(n)21.2(c)-376.7(In)19.6(te)18.4(rn)13.9(a-)]TJ
0 -1.0528 TD
[(ti)16.5(on)21.2(al)12.8(,)-404.4(R)0(o)16.5(s)0(k)20(i)0(l)16.5(d)0(e)15.1(,)-404.4(De)11.2(nm)18.1(ar)19.2(k\))-401.5(in)-396.6(th)13.2(e)-405.2(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(c)0(e)-400.7(o)0(f)-401.5(P)11.4(HA)-402(\(5)13.9(0)]TJ
/F10 1 Tf
0 -1.0471 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
(g)Tj
/F12 1 Tf
0.4894 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 85.039 158.797 Tm
(-1)Tj
9.963 0 0 9.963 90.992 154.375 Tm
[(\))-366.6(f)0(o)13.9(r)-366.6(48)-360(h)-370.7(a)0(t)-362.8(3)0(7)]TJ
/F11 1 Tf
6.4702 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
0.3702 Tc
[(Cw)370.2(i)385.1(t)384.1(h5)370.2(%)7.8(C)370.2(O)]TJ
7.472 0 0 6.641 220.876 152.731 Tm
0 Tc
(2)Tj
9.963 0 0 9.963 224.504 154.375 Tm
[(.)-370.3(P)11.4(oo)15.5(le)18.4(d)-370.7(s)0(u)20(p)0(e)15.1(r)20.4(-)]TJ
-16.6847 -1.0528 TD
[(na)15.1(ta)18.4(nt)18.9(s)-462.9(w)0(e)16.9(r)0(e)-458.8(k)0(e)15.1(p)0(t)-453.5(a)0(t)-459.6(-)0(7)19.6(0)]TJ
/F11 1 Tf
10.169 0 TD
(8)Tj
/F3 1 Tf
0.3813 0 TD
-0.016 Tc
[(C.)-483(Su)-16(bs)-16(eq)-16(ue)-16(n)4.8(t)-16(ly)57.2(,)-483(l)-16(ym)-16(ph)-16(oc)-16(yt)-16(es)]TJ
-10.5503 -1.0471 TD
0 Tc
[(we)16.9(re)-424.6(pu)21.2(ls)17.7(ed)-423(wi)14.9(th)-425(9.)21.6(25)-422.6(kB)16.5(q)]TJ
7.472 0 0 6.641 174.841 137.877 Tm
(3)Tj
9.963 0 0 9.963 178.469 133.455 Tm
[(H-)15.7(th)18.9(ym)18.1(id)13.2(in)18.9(e)-433.7(f)0(o)19.6(r)-429.2(18)-422.6(h)-433.3(a)0(n)15.1(d)]TJ
-12.064 -1.0528 TD
[(th)18.9(ym)18.1(id)13.2(in)18.9(e)-359.7(i)0(n)13.2(c)0(o)20.8(r)0(p)13.9(o)0(r)19.6(a)0(t)18.4(i)0(o)18.9(n)-365(wa)16.9(s)-366.2(m)0(e)17.7(a)0(s)19.6(u)0(r)14(e)0(d)-349.1(\()0(l)17.3(y)0(m)12.4(p)0(h)21.2(o)0(p)15.5(r)0(o)19.6(l)0(i)16.5(f)0(e)19.2(r)0(a)13.5(-)]TJ
0 -1.0471 TD
[(ti)16.5(ve)-314.9(re)19.2(sp)14.4(on)21.2(se)13.9(\).)]TJ
/F5 1 Tf
25.1977 66.1583 TD
[(Cyt)-9.8(okine)-337.1(assays)]TJ
/F3 1 Tf
1.0015 -1.4511 TD
[(In)-270.6(pl)18.9(as)19.6(ma)17.7(,)-273.5(I)0(L)15.5(-)0(4)19.6(,)-273.5(IL)15.5(-8)19.6(,)-273.5(I)0(L)15.5(-)0(1)13.9(2)-268.2(an)15.1(d)-273.9(I)0(F)14.7(N)12.4(-)]TJ
/F8 1 Tf
14.8922 0 TD
(c)Tj
/F3 1 Tf
0.7739 0 TD
[(we)16.9(re)-271(m)13.2(e)0(a)14.7(s)0(u)20(r)0(e)13.5(d)0(.)]TJ
-16.6676 -1.0471 TD
[(In)-503.9(su)20(pe)15.1(rn)19.6(at)18.4(an)15.1(ts)17.7(,)-506.8(I)0(L)15.5(-)0(4)-498.2(a)0(n)20.8(d)-507.2(IF)14.7(N-)]TJ
/F8 1 Tf
12.9574 0 TD
(c)Tj
/F3 1 Tf
1.0072 0 TD
[(we)16.9(re)-498.6(me)12(as)19.6(ur)19.6(ed)15.1(.)-506.8(C)0(o)16.5(n)0(-)]TJ
-13.9646 -1.0527 TD
[(ce)14.7(nt)18.9(ra)13.5(t)13.9(i)0(o)13.2(n)0(s)-236(o)0(f)-236.4(I)0(L)21.2(-)0(4)-242.1(\()0(s)18.4(u)0(p)21.2(e)0(r)13.5(n)0(a)20.8(t)0(a)18.4(n)0(t)13.2(s)0(\))18.4(,)-245.1(IL)21.2(-8)-242.1(an)20.8(d)-245.5(I)0(F)14.7(N)12.4(-)]TJ
/F8 1 Tf
18.9837 0 TD
(c)Tj
/F3 1 Tf
0.7455 0 TD
[(\(p)14(la)18.4(sm)16.9(a)]TJ
-19.7291 -1.0471 TD
[(an)15.1(d)-416.2(s)0(u)20(p)0(e)20.8(r)0(n)13.9(a)0(t)18.5(a)0(n)15.1(t)0(s)17.7(\))-412.1(we)16.9(re)-407.6(de)20.8(te)12.8(rm)16.5(in)18.9(ed)-406(us)20(in)18.9(g)-416.2(e)0(n)20.8(z)0(y)15.1(m)0(e)17.7(-)0(l)17.3(i)0(n)18.9(k)0(e)15.1(d)]TJ
0 -1.0527 TD
[(im)15.7(mu)12.4(no)21.2(so)20(rb)14(en)20.8(t)-276.3(a)0(s)19.6(s)0(a)13.9(y)-268.2(\(E)15.5(LI)15.5(S)11.4(A)0(\))-263.1(k)0(i)13.2(t)0(s)-261.2(s)0(u)20(p)0(p)15.5(l)0(i)16.5(e)0(d)-263.7(b)0(y)-263.3(t)0(h)18.8(e)-274.3(Du)17.3(tc)18.4(h)]TJ
0 -1.0471 TD
[(La)16.7(bo)15.5(ra)19.2(to)18.8(ry)-429.9(fo)19.6(r)-434.8(B)0(l)14.1(o)0(o)21.2(d)-433.3(T)40.6(r)0(a)13.5(n)0(s)20(f)0(u)19.6(s)0(i)12(o)0(n)-422.6(\()0(A)15.7(m)0(s)16.9(t)0(e)18.4(r)0(d)19.6(a)0(m)12(,)-432.9(th)18.8(e)-433.6(N)0(e)16.9(-)]TJ
0 -1.0527 TD
[(th)13.2(er)19.2(la)18.4(nd)15.5(s\))18.4(;)-213.7(t)0(h)18.8(e)-217.4(de)20.8(te)18.5(ct)12.8(io)18.9(n)-211.3(l)0(i)16.5(m)0(i)15.7(t)-213.7(fo)13.9(r)-212.9(I)0(L)15.5(-)0(4)-202.3(w)0(a)16.9(s)-212.5(4.)15.9(7)-211.3(p)0(g)]TJ
/F12 1 Tf
18.9837 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 514.658 698.853 Tm
(-1)Tj
9.963 0 0 9.963 520.611 694.431 Tm
0.2166 Tc
[(,f)216.6(o)236.2(r)]TJ
-21.2087 -1.0471 TD
0 Tc
[(IL)15.5(-8)-549.4(2.)21.6(5)-558.4(p)0(g)]TJ
/F12 1 Tf
5.0475 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 375.817 688.422 Tm
(-1)Tj
9.963 0 0 9.963 387.439 684 Tm
[(an)20.8(d)-558.4(f)0(o)19.6(r)-554.3(IF)14.7(N-)]TJ
/F8 1 Tf
5.5369 0 TD
(c)Tj
/F3 1 Tf
1.0527 0 TD
[(25)-547.8(pg)]TJ
/F12 1 Tf
2.5323 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 494.532 688.422 Tm
(-1)Tj
9.963 0 0 9.963 500.485 684 Tm
0.5524 Tc
[(.P)552.4(l)566.3(a)552.4(s)572(m)552.4(a)]TJ
-19.1885 -1.0527 TD
0 Tc
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[(Wh)14.4(it)16.5(e)-575.9(b)0(l)18.9(o)0(o)15.5(d)-575.5(ce)14.7(ll)-569.7(co)20.8(un)15.5(ts)17.7(,)-575.1(a)0(n)15.1(d)-575.5(re)13.5(la)18.4(ti)16.5(ve)-571(an)20.8(d)-581.2(a)0(b)20.8(s)0(o)20(l)0(u)13.2(t)0(e)]TJ
-1.0015 -1.0527 TD
[(ly)18.9(mp)18.1(ho)15.5(cy)15.1(te)-357.1(nu)15.5(m)13.2(b)0(e)15.1(r)0(s)-357.1(o)0(f)-361.6(v)0(e)20.8(n)0(t)13.2(i)0(l)16.5(a)0(t)18.4(e)0(d)-354.8(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-363.6(d)0(i)18.9(d)-365(no)15.5(t)-367.3(d)0(i)18.9(f)20.4(fe)13.5(r)]TJ
0 -1.0471 TD
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(tl)16.5(y)-404.8(f)0(r)12.4(o)0(m)-397.3(n)0(o)21.2(n)0(v)15.5(e)0(n)20.8(t)0(i)16.5(l)0(a)18.4(t)0(e)18.4(d)-410.5(pa)20.8(ti)16.5(en)20.8(ts)12(,)-404.4(a)0(l)18.4(t)0(h)18.9(o)0(u)15.5(g)0(h)-394.2(a)0(b)20.8(s)0(o)14.4(-)]TJ
0 -1.0527 TD
[(lu)18.9(te)-340.1(ly)18.9(mp)12.4(ho)21.2(cy)15.1(te)-340.1(nu)21.2(mb)12.4(er)19.2(s)-349.1(i)0(n)-339.7(v)0(e)20.8(n)0(t)18.9(i)0(l)16.5(a)0(t)12.8(e)0(d)-337.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-340.8(t)0(e)18.4(n)0(d)21.2(e)0(d)-343.4(t)0(o)]TJ
0 -1.0471 TD
[(be)-462.9(lo)18.9(we)16.9(r)-469(t)0(h)18.9(a)0(n)-462.9(i)0(n)-459.2(n)0(o)15.5(n)0(v)21.2(e)0(n)15.1(t)0(i)16.5(l)13.9(at)12.8(ed)-457.2(pa)15.1(ti)16.5(en)20.8(ts)-460.3(\(3)]TJ
/F11 1 Tf
17.4984 0 TD
(6)Tj
/F3 1 Tf
0.9902 0 TD
(10)Tj
7.472 0 0 6.641 252.283 546.463 Tm
(9)Tj
/F5 1 Tf
9.963 0 0 9.963 260.674 542.041 Tm
[(ve)20.4(rs)18.9(us)]TJ
/F3 1 Tf
-20.3153 -1.0527 TD
[(4.)15.9(2)]TJ
/F11 1 Tf
1.2235 0 TD
(6)Tj
/F3 1 Tf
0.9902 0 TD
(10)Tj
7.472 0 0 6.641 90.142 535.975 Tm
(9)Tj
9.963 0 0 9.963 97.228 531.553 Tm
[(ce)20.4(ll)16.5(s)]TJ
/F12 1 Tf
1.7527 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(L)Tj
7.472 0 0 6.641 123.364 535.975 Tm
(-1)Tj
9.963 0 0 9.963 129.316 531.553 Tm
[(\).)-327.1(L)57.7(y)0(m)18.1(p)0(h)21.2(o)0(p)15.5(r)0(o)19.6(l)0(i)16.5(f)0(e)13.5(r)0(a)19.2(t)0(i)16.5(v)0(e)-326.3(r)0(e)13.5(s)0(p)20(o)0(n)15.5(s)0(e)19.6(s)-337.7(in)-328.3(th)13.2(e)]TJ
-7.1303 -1.0471 TD
[(ac)14.7(ut)18.9(e)-217.4(p)0(h)15.5(a)0(s)19.6(e)-223.1(ar)19.2(e)-223.1(s)0(h)20(o)0(w)17.3(n)-222.7(in)-208.8(fi)17.3(g.)-211.7(2.)-217.4(Mean)-239.1(lymphopro)-8.3(liferati)-13.9(ve)]TJ
0 -1.0527 TD
[(respon)-7.8(ses)-209.9(in)-214.5(venti)-9(lated)-214.2(patients)-220.1(and)-213.2(nonvent)-8.1(ilated)-217.4(patients)]TJ
0 -1.0471 TD
[(were)-339.4(lower)-342.2(than)-335.9(in)-334(co)-7.6(ntrols)-336.5(\(14,000\213)-11.8(2,500)-333.5(and)-338.4(29,000\213)]TJ
0 -1.0527 TD
(4,500)Tj
/F5 1 Tf
2.7941 0 TD
(versus)Tj
/F3 1 Tf
3.0729 0 TD
[(42,000\213)-9.5(2,800)-538.3(co)-7.6(unts)-541.5(per)-539.2(min)-7.8(ute)-540(\(cpm)-8.2(\),)]TJ
-5.867 -1.0471 TD
(p)Tj
/F10 1 Tf
0.5008 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001\).)-552.5(L)52(ympho)-7(prolifera)-11.5(tive)-548.8(respon)-7.8(ses)-545.7(in)-550.2(ventilat)-10.7(ed)]TJ
-1.0528 -1.0527 TD
[(patien)-10.1(ts)-454.7(wer)-8.2(e)-456.4(lower)-467.4(than)-461.1(in)-459.2(nonvent)-8.1(ilated)-462.1(pati)-8.2(ents)-462.3(\(p)]TJ
/F10 1 Tf
22.2444 0 TD
(<)Tj
/F3 1 Tf
-22.2444 -1.0471 TD
[(0.005\).)-484.2(In)-475.4(the)-477.4(conval)-7.8(escent)-481.7(phase,)-484.2(lymphopro)-8.3(liferati)-13.9(ve)]TJ
0 -1.0528 TD
[(respon)-7.8(ses)-443.2(returned)-450.7(to)-436.4(no)-7.2(rmal)-443.1(values)-447.1(in)-442.1(both)-443.6(ventilat)-10.7(ed)]TJ
0 -1.0471 TD
[(and)-338.4(nonvent)-8.1(ilated)-336.9(pati)-8.2(ents.)]TJ
1.0015 -1.0527 TD
[(Ag)17.3(e)-257.2(w)12.4(as)-247.8(re)13.5(l)13.9(a)0(t)12.8(e)0(d)-240.9(t)0(o)-248.6(l)0(y)18.9(m)0(p)18.1(h)0(o)15.5(p)0(r)19.6(o)0(l)13.2(i)13.9(fe)13.5(ra)19.2(ti)16.5(ve)-246.6(re)19.2(sp)14.4(on)21.2(se)13.9(s)-252.3(i)0(n)-242.9(t)0(h)13.2(e)]TJ
-1.0015 -1.0471 TD
[(co)15.1(nt)18.9(ro)19.6(l)-390.1(i)0(n)18.9(f)0(a)13.5(n)0(t)18.9(s)0(,)-377.9(a)0(l)12.8(t)0(h)18.9(o)0(u)21.2(g)0(h)-382.8(n)0(o)-382.8(a)0(s)19.6(s)0(o)20(c)0(i)12.8(a)0(t)18.4(i)0(o)18.9(n)-387.7(wa)11.2(s)-388.9(f)0(o)19.6(u)0(n)15.5(d)-387.7(\(d)19.6(at)12.8(a)]TJ
0 -1.0527 TD
[(no)15.5(t)-321.8(s)0(h)20(o)0(w)17.3(n)0(\))13.9(.)]TJ
/F5 1 Tf
0 -2.4242 TD
[(Cytoki)-9.2(ne)-411.7(pr)25.7(oduction)-421(in)-413.6(phytoh)-7.4(aema)-7.4(gglutinin-st)-12.5(imulat)-10(ed)]TJ
0 -1.0528 TD
[(whole)-341.4(blood)-336.2(cultu)-9(r)32.2(e)0(s)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(Le)16.7(ve)15.1(l)13.9(s)-531.2(of)-521(IL)15.5(-4)-521(an)20.8(d)-530(I)0(F)14.7(N)12.4(-)]TJ
/F8 1 Tf
10.5389 0 TD
(c)Tj
/F3 1 Tf
1.03 0 TD
[(in)-521.7(th)18.9(e)-530.4(a)0(c)14.7(u)0(t)18.9(e)-530.4(ph)21.2(as)13.9(e)-524.7(f)0(r)12.4(o)0(m)]TJ
-12.5704 -1.0471 TD
[(su)20(pe)15.1(rn)19.6(at)12.8(an)20.8(ts)-318.1(of)-316.1(P)11.4(H)0(A)-316.7(s)0(t)17.7(i)0(m)15.7(u)0(l)18.9(a)0(t)12.8(e)0(d)-314.9(w)0(h)17.3(o)0(l)18.9(e)-325.5(bl)18.9(oo)15.5(d)-319.4(c)0(u)15.1(l)0(t)16.5(u)0(r)19.6(e)0(s)-316.1(a)0(r)13.5(e)]TJ
0 -1.0528 TD
[(sh)20(ow)17.3(n)-302.4(i)0(n)-288.4(f)0(i)17.3(g)0(u)15.5(r)0(e)-293.7(3)0(.)-297.1(I)0(n)-310.4(venti)-9(lated)-311(pati)-8.2(ents,)-314.7(IFN-)]TJ
/F8 1 Tf
18.4886 0 TD
(c)Tj
/F3 1 Tf
0.8081 0 TD
[(and)-315.7(IL-4)]TJ
5.9011 19.5357 TD
[(level)-9.4(s)-223.9(were)-225.6(below)-232.5(the)-227(detection)-231.5(level)-231.3(in)-225.8(1)33.4(1)-222.7(out)-226.6(of)-225.1(13)-223.5(cases)]TJ
0 -1.0527 TD
[(\(85%\))-9.4(;)-373(i)0(n)-368.1(nonvent)-8.1(ilated)-376.7(pati)-8.2(ents)-371.2(and)-372.6(in)-373.8(control)-376.3(subjects)]TJ
0 -1.0471 TD
[(cytoki)-9.7(ne)-474.3(level)-9.4(s)-474.3(could)-478.9(be)-479.9(measured)-485.6(in)-476.2(all)-474.1(samp)-7.8(les)-478.6(\(p)]TJ
/F10 1 Tf
22.2501 0 TD
(<)Tj
/F3 1 Tf
-22.2501 -1.0527 TD
[(0.00)-8.4(1\).)-441.7(No)-443.6(signifi)-9.6(cant)-444.4(differences)-445.2(wer)-8.2(e)-439.3(found)-449.3(between)]TJ
0 -1.0471 TD
[(non)-8(ventilated)-228.9(patients)-225.8(and)-224.6(control)-228.3(subjects)-224.6(for)-221.7(both)-227.4(IFN-)]TJ
/F8 1 Tf
22.3013 0 TD
(c)Tj
/F3 1 Tf
-22.3013 -1.0527 TD
[(and)-514.8(IL-4.)-511.5(In)-509.6(the)-517.2(convalescent)-517.9(phase,)-518.3(IFN-)]TJ
/F8 1 Tf
18.0903 0 TD
(c)Tj
/F3 1 Tf
1.0072 0 TD
[(a)-6.9(n)0(d)-508(IL-4)]TJ
-19.0975 -1.0471 TD
[(level)-9.4(s)-332(wer)-8.2(e)-331.2(norm)-7.8(al)-334.4(in)-334(both)-341.2(patient)-337.7(groups)-7.4(.)]TJ
1.0015 -1.0527 TD
[(Ag)11.6(e)-268.6(w)0(a)16.9(s)-275.1(re)19.2(la)18.5(te)18.4(d)-273.9(t)0(o)-260(I)0(L)15.5(-)0(4)-264.9(a)0(n)20.8(d)-273.9(IF)20.4(N-)]TJ
/F8 1 Tf
13.1964 0 TD
(c)Tj
/F3 1 Tf
0.7739 0 TD
[(re)19.2(sp)20(on)15.5(se)19.6(s)-275.1(i)0(n)-260(c)0(o)15.1(n)0(t)18.9(r)0(o)19.6(l)]TJ
-14.9718 -1.0528 TD
[(in)13.2(fa)19.2(nt)18.9(s)-223.9(\()0(d)13.9(a)0(t)18.4(a)-223.1(no)21.2(t)-225.1(s)0(h)14.4(o)0(w)17.3(n)0(\))19.6(.)-222.3(Ag)17.3(e)-223.1(w)0(a)11.2(s)-218.2(no)15.5(t)-225.1(a)0(s)19.6(s)0(o)14.4(c)0(i)18.5(a)0(t)18.4(e)0(d)-212.5(w)0(i)14.9(t)0(h)-214.5(I)0(L)15.5(-)0(4)]TJ
0 -1.0471 TD
[(re)13.5(sp)20(on)15.5(se)19.6(s,)-389.3(bu)21.2(t)-401.5(a)-393.8(po)15.5(si)17.7(ti)16.5(ve)-388.9(co)20.8(rr)12.4(el)18.5(at)18.5(io)18.9(n)-399.1(w)0(a)16.9(s)-400.3(fo)19.6(un)21.2(d)-399.1(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)]TJ
0 -1.0527 TD
[(ag)15.1(e)-234.5(a)0(n)15.1(d)-234.1(IF)14.7(N-)]TJ
/F8 1 Tf
5.1329 0 TD
(c)Tj
/F3 1 Tf
0.7341 0 TD
[(re)19.2(sp)14.4(on)21.2(se)14(s)-235.3(\()0(r)]TJ
/F10 1 Tf
4.6435 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(52)15.5(,)-233.7(p)]TJ
/F10 1 Tf
2.6859 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(01)15.5(\).)-224.7(Ho)11.6(w)12.4(e)0(v)15.1(e)0(r)47.7(,)-233.7(ne)15.1(ar)30.6(-)]TJ
-14.289 -1.0471 TD
[(ly)-203.1(al)18.4(l)-208(I)0(F)20.4(N)0(-)]TJ
/F8 1 Tf
4.0175 0 TD
(c)Tj
/F3 1 Tf
0.7056 0 TD
[(re)13.5(sp)20(on)15.5(se)19.6(s)-206.8(i)0(n)-197.4(v)0(e)15.1(n)0(t)18.9(i)0(l)16.5(a)0(t)18.5(e)0(d)-201.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-198.6(w)0(e)16.9(r)0(e)-197(b)0(e)15.1(l)0(o)18.9(w)-209.6(th)18.9(e)]TJ
-4.7232 -1.0528 TD
[(mi)15.7(ni)13.2(m)13.2(u)0(m)-306.3(I)0(F)14.7(N)12.4(-)]TJ
/F8 1 Tf
5.9978 0 TD
(c)Tj
/F3 1 Tf
0.8081 0 TD
[(re)13.5(sp)20(on)15.5(se)-299(fo)13.9(un)21.2(d)-313.7(i)0(n)-305.5(n)0(o)21.2(n)0(v)15.5(e)0(n)20.8(t)0(i)16.5(l)0(a)18.4(t)0(e)12.8(d)-308.1(pa)15.1(ti)16.5(en)20.8(ts)]TJ
-6.8059 -1.0471 TD
[(an)15.1(d)-251.2(c)0(o)15.1(n)0(t)18.9(r)0(o)13.9(l)-253.5(in)18.8(fa)19.2(nt)18.9(s.)-247(IL)15.5(-4)19.6(/I)17.3(F)11.4(N)0(-)]TJ
/F8 1 Tf
11.6542 0 TD
(c)Tj
/F3 1 Tf
0.7568 0 TD
[(ra)19.2(ti)16.5(os)-247.4(in)-242.9(th)18.8(e)-257.2(a)0(c)20.4(u)0(t)18.8(e)-257.2(ph)21.2(as)13.9(e)-251.6(i)0(n)]TJ
-12.4111 -1.0528 TD
[(ve)15.1(nt)18.9(il)16.5(at)18.5(ed)-599.4(pa)15.1(ti)16.5(en)20.8(ts)-602.6(co)15.1(ul)18.9(d)-609.7(n)0(o)21.2(t)-612(be)-599.4(de)15.1(te)18.4(rm)16.5(in)18.9(ed)15.1(,)-609.3(s)0(i)17.7(n)0(c)20.8(e)-610.1(in)]TJ
0 -1.0471 TD
[(pr)13.9(ac)20.4(ti)16.5(ca)14.7(ll)16.5(y)-205.6(a)0(l)18.5(l)-202.3(pa)15.1(ti)16.5(en)20.8(ts)-198.6(IL)15.5(-4)-196.6(an)20.8(d/)13.2(or)-196.6(IF)20.4(N-)]TJ
/F8 1 Tf
15.1482 0 TD
(c)Tj
/F3 1 Tf
0.7056 0 TD
[(le)18.5(ve)15.1(ls)-198.6(w)12.4(e)0(r)13.5(e)-206(be)20.8(lo)13.2(w)]TJ
-15.8539 -1.0527 TD
[(th)13.2(e)-308.5(d)0(e)20.8(t)0(e)18.4(c)0(t)12.8(i)13.9(on)-303.1(le)18.4(ve)20.8(l.)-299.4(IL)15.5(-4)19.6(/I)17.3(FN)12.4(-)]TJ
/F8 1 Tf
11.6429 0 TD
(c)Tj
/F3 1 Tf
0.8081 0 TD
[(ra)19.2(ti)16.5(os)-298.6(in)-299.8(no)21.2(nv)15.5(en)20.8(ti)16.5(la)12.8(t)13.9(e)0(d)-303.5(p)0(a)20.8(-)]TJ
-12.4509 -1.0471 TD
[(ti)16.5(en)15.1(ts)-261.2(we)11.2(re)-265.3(no)21.2(t)-276.3(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)0(l)16.5(y)-273.9(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(t)-265.7(f)0(r)18(o)0(m)-266.4(c)0(o)20.8(n)0(t)13.2(r)0(o)19.6(l)0(s)17.7(.)-273.5(In)-264.9(th)18.9(e)]TJ
0 -1.0527 TD
[(co)15.1(nv)15.5(al)18.4(es)19.6(ce)14.7(nt)-311.2(ph)15.5(as)19.6(e,)-314.5(IL)15.5(-4)19.6(/I)11.6(F)11.4(N)0(-)]TJ
/F8 1 Tf
11.9843 0 TD
(c)Tj
/F3 1 Tf
0.8251 0 TD
[(ra)19.2(ti)16.5(os)-315.7(re)19.2(ma)17.7(in)13.2(ed)-314.9(no)21.2(rm)16.5(al)12.8(.)]TJ
/F7 1 Tf
-3.6419 -2.1169 TD
[(Discu)-10.9(ssion)]TJ
/F3 1 Tf
-8.1659 -1.8494 TD
[(In)-424.2(th)18.9(is)-420.5(st)17.7(ud)21.2(y)67.5(,)-427.2(IL)15.5(-8)-418.5(pl)18.9(as)19.6(ma)-426.2(le)18.4(ve)20.8(ls)17.7(,)-432.9(l)13.9(ym)12.4(ph)21.2(op)15.5(ro)19.6(li)16.5(fe)19.2(ra)13.5(ti)16.5(ve)]TJ
-1.0015 -1.0471 TD
[(re)13.5(sp)20(on)15.5(se)19.6(s)-201.1(a)0(n)15.1(d)-199.9(ly)18.8(mp)12.4(ho)21.2(cy)15.1(te)-192.1(cy)15.1(to)18.9(ki)18.9(ne)-195.4(re)19.2(sp)20(on)15.5(se)19.6(s)]TJ
/F5 1 Tf
17.9537 0 TD
[(i)13.9(n)-205.6(vi)18.4(tr)46.1(o)]TJ
/F3 1 Tf
2.9591 0 TD
[(we)16.9(re)]TJ
-20.9128 -1.0528 TD
[(as)13.9(so)20(ci)18.4(at)12.8(ed)-451.5(wi)14.9(th)-453.5(di)18.9(se)13.9(as)19.6(e)-462.1(s)0(e)13.9(v)0(e)20.8(r)0(i)17.3(t)0(y)-453.5(i)0(n)-459.2(h)0(o)21.2(s)0(p)20(i)0(t)16.5(a)0(l)12.8(i)13.9(ze)14.7(d)-461.7(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)]TJ
0 -1.0471 TD
[(wi)14.9(th)-544.5(RS)17.3(V)-556.7(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(o)13.2(l)13.9(it)16.5(is)17.7(.)-552.4(L)57.7(ym)18.1(ph)15.5(op)21.2(ro)13.9(li)16.5(fe)19.2(ra)19.2(ti)16.5(ve)-542.5(re)13.5(sp)20(on)15.5(se)19.6(s)]TJ
0 -1.0527 TD
[(du)15.5(ri)17.3(ng)-212.1(ac)14.7(ut)18.9(e)-217.4(d)0(i)13.2(s)0(e)19.6(a)0(s)19.6(e)-223.1(ar)13.5(e)-217.4(l)0(o)18.9(w)0(e)16.9(r)-224.3(in)-214.5(ve)20.8(nt)18.8(il)16.5(at)18.5(ed)-212.5(pa)15.1(ti)16.5(en)20.8(ts)-215.6(th)18.9(an)-212.5(in)]TJ
0 -1.0471 TD
[(no)15.5(nv)15.5(en)20.8(ti)16.5(la)18.4(te)18.4(d)-410.5(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(.)-410.1(Mo)19.3(st)-403.4(st)17.7(ri)17.3(ki)18.9(ng)-399.9(is)-403.4(th)18.9(e)-410.9(a)0(l)18.4(m)0(o)18.1(s)0(t)-403.4(c)0(o)20.8(m)0(-)]TJ
0 -1.0528 TD
[(pl)13.2(et)18.4(el)18.5(y)-319.4(n)0(e)15.1(g)0(a)20.8(t)0(i)16.5(v)0(e)-314.9(r)0(e)19.2(s)0(p)20(o)0(n)15.5(s)0(e)-310.4(o)0(f)-310.4(I)0(F)14.7(N)0(-)]TJ
/F8 1 Tf
13.3045 0 TD
(c)Tj
/F3 1 Tf
0.8194 0 TD
[(an)15.1(d)-319.4(I)0(L)15.5(-)0(4)-310.4(i)0(n)-311.2(v)0(e)20.8(n)0(t)13.2(i)0(l)16.5(a)0(t)18.4(e)0(d)]TJ
-14.1239 -1.0527 TD
[(pa)15.1(ti)16.5(en)20.8(ts)17.7(.)-324.7(I)0(n)-321.8(t)0(h)18.9(e)-325.5(co)15.1(nv)21.2(al)18.4(es)14(ce)20.4(nt)-316.9(ph)15.5(as)19.6(e)-325.5(p)0(l)13.2(a)0(s)19.6(m)0(a)-318.1(I)0(L)15.5(-)0(8)19.6(,)-324.7(ly)18.8(mp)12.4(ho)21.2(-)]TJ
0 -1.0471 TD
[(pr)13.9(ol)18.9(if)17.3(er)19.2(at)12.8(iv)18.8(e)-365.4(r)0(e)13.5(s)0(p)20(o)0(n)15.5(s)0(e)19.6(s)-366.2(an)15.1(d)-365(c)0(y)15.1(t)0(o)18.9(k)0(i)18.9(n)0(e)-360.4(r)0(e)19.2(s)0(p)14.4(o)0(n)21.2(s)0(e)13.9(s)-366.2(no)15.5(rm)16.5(al)18.4(iz)18.4(e)]TJ
0 -1.0527 TD
[(in)-316.9(bo)15.5(th)-311.2(ve)15.1(nt)18.9(il)16.5(at)18.4(ed)-314.9(an)15.1(d)-325.1(n)0(o)21.2(n)0(v)15.5(e)0(n)20.8(t)0(i)16.5(l)0(a)18.4(t)0(e)12.8(d)-319.4(pa)15.1(ti)16.5(en)20.8(ts)17.7(.)]TJ
1.0015 -1.0471 TD
[(Y)97.7(o)0(u)21.2(n)0(g)-416.9(a)0(g)20.8(e)-422.3(an)15.1(d)-421.9(p)0(r)19.6(e)0(m)17.7(a)0(t)18.5(u)0(r)13.9(i)0(t)16.5(y)-421.9(ap)20.8(pe)15.1(ar)19.2(ed)-411.7(to)-413.6(be)-411.6(im)15.7(po)15.5(rt)17.3(an)20.8(t)]TJ
-1.0015 -1.0527 TD
[(fa)13.5(ct)18.4(or)19.6(s)-269.4(i)0(n)-254.3(d)0(e)15.1(t)0(e)18.4(r)0(m)16.5(i)0(n)18.9(i)0(n)18.8(g)-268.2(di)18.9(se)13.9(as)19.6(e)-262.9(s)0(e)13.9(v)0(e)20.8(r)0(i)17.3(t)0(y)75.8(.)-262.1(Th)17.1(e)-268.6(m)0(e)17.7(d)0(i)18.8(a)0(n)-258(a)0(g)20.8(e)-268.6(of)]TJ
0 -1.0471 TD
[(th)13.2(e)-285.7(v)0(e)20.8(n)0(t)18.9(i)0(l)16.5(a)0(t)18.5(e)0(d)-280.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-272.6(w)0(a)16.9(s)-286.5(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(t)13.9(l)0(y)-277.1(l)0(o)13.2(w)12.4(er)-276.7(th)13.2(an)-275.1(th)18.8(at)-277.5(of)]TJ
0 -1.0528 TD
[(th)13.2(e)-297.1(n)0(o)15.5(n)0(v)21.2(e)0(n)15.1(t)0(i)16.5(l)0(a)18.4(t)0(e)18.4(d)-302.4(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)0(;)-289.6(e)0(x)15.1(c)0(e)20.4(p)0(t)-294.1(f)0(o)19.6(r)-304(on)15.5(e)-297.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(,)-293.7(a)0(l)18.5(l)-299.1(ve)15.1(n-)]TJ
0 -1.0471 TD
[(ti)16.5(la)18.4(te)12.8(d)-365(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-357.9(w)0(e)16.9(r)0(e)]TJ
/F10 1 Tf
8.4049 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(3)-370.7(m)0(o)18.1(n)0(t)18.8(h)0(s)-361.2(o)0(l)18.9(d)0(.)-359.7(F)11.4(ur)19.6(th)13.2(er)19.2(mo)18.1(re)13.5(,)-364.6(i)0(t)-359.1(w)0(a)16.9(s)]TJ
-8.9455 -1.0528 TD
[(fo)13.9(un)21.2(d)-547.1(t)0(h)18.9(a)0(t)-539.2(m)0(o)18.1(r)0(e)-538.4(v)0(e)20.8(n)0(t)13.2(i)13.9(la)12.8(te)18.4(d)-547.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s)-548.3(t)0(h)18.8(a)0(n)-536.8(n)0(o)15.5(n)0(v)21.2(e)0(n)15.1(t)0(i)16.5(l)0(a)18.4(t)0(e)18.4(d)]TJ
0 -1.0471 TD
[(pa)15.1(ti)16.5(en)20.8(ts)-312.4(we)16.9(re)-310.8(bo)21.2(rn)-310.4(pr)14(em)17.7(at)18.5(ur)19.6(el)12.8(y)73.2(.)-319.1(B)11.6(o)0(t)18.9(h)-319.4(yo)15.5(un)21.2(g)-319.4(a)0(g)15.1(e)-314.2(an)15.1(d)-319.4(p)0(r)19.6(e)0(-)]TJ
0 -1.0528 TD
[(ma)12(tu)18.8(re)-231.2(bi)13.2(rt)17.3(h)-239.8(a)0(r)19.2(e)-245.9(kn)21.2(ow)17.3(n)-245.5(r)0(i)17.3(s)0(k)-230.3(f)0(a)13.5(c)0(t)18.4(o)0(r)19.6(s)-246.7(fo)19.6(r)-241.4(t)0(h)18.8(e)-245.9(de)20.8(ve)15.1(lo)18.9(pm)18.1(en)15.1(t)-242.1(o)0(f)]TJ
0 -1.0471 TD
[(se)13.9(ve)20.8(re)-316.5(br)13.9(on)21.2(ch)15.1(io)18.9(li)16.5(ti)16.5(s)-320.6([)0(1)13.9(8].)]TJ
/F16 1 Tf
10 0 0 10 90.972 286.137 Tm
0 0 0 1 k
/GS3 gs
(1000)Tj
0 10 -10 0 67.492 201.068 Tm
(Plasma IL-8  pg\341mL)Tj
0 8 -8 0 65.224 272.168 Tm
(-1)Tj
10 0 0 10 95.472 246.996 Tm
(100)Tj
0.4625 -4.0308 TD
(10)Tj
0.5625 -3.8933 TD
(1)Tj
14.5008 -1.5311 TD
(Control)Tj
-0.1824 -1 TD
(subjects)Tj
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS4 gs
1 i 
117.413 170.016 m
112.413 170.016 l
117.215 209.873 m
112.215 209.873 l
117.328 249.73 m
112.328 249.73 l
117.347 289.586 m
112.347 289.586 l
117.352 289.568 m
117.352 169.819 l
S
151.647 289.768 m
151.647 290.265 152.05 290.668 152.547 290.668 c
153.044 290.668 153.447 290.265 153.447 289.768 c
153.447 289.271 153.044 288.868 152.547 288.868 c
152.05 288.868 151.647 289.271 151.647 289.768 c
b
154.547 270.668 m
154.547 271.165 154.95 271.568 155.447 271.568 c
155.944 271.568 156.347 271.165 156.347 270.668 c
156.347 270.171 155.944 269.768 155.447 269.768 c
154.95 269.768 154.547 270.171 154.547 270.668 c
b
151.947 269.468 m
151.947 269.965 152.35 270.368 152.847 270.368 c
153.344 270.368 153.747 269.965 153.747 269.468 c
153.747 268.971 153.344 268.568 152.847 268.568 c
152.35 268.568 151.947 268.971 151.947 269.468 c
b
152.147 249.668 m
152.147 250.165 152.55 250.568 153.047 250.568 c
153.544 250.568 153.947 250.165 153.947 249.668 c
153.947 249.171 153.544 248.768 153.047 248.768 c
152.55 248.768 152.147 249.171 152.147 249.668 c
b
152.347 238.268 m
152.347 238.765 152.75 239.168 153.247 239.168 c
153.744 239.168 154.147 238.765 154.147 238.268 c
154.147 237.771 153.744 237.368 153.247 237.368 c
152.75 237.368 152.347 237.771 152.347 238.268 c
b
152.547 229.968 m
152.547 230.465 152.95 230.868 153.447 230.868 c
153.944 230.868 154.347 230.465 154.347 229.968 c
154.347 229.471 153.944 229.068 153.447 229.068 c
152.95 229.068 152.547 229.471 152.547 229.968 c
b
152.347 227.068 m
152.347 227.565 152.75 227.968 153.247 227.968 c
153.744 227.968 154.147 227.565 154.147 227.068 c
154.147 226.571 153.744 226.168 153.247 226.168 c
152.75 226.168 152.347 226.571 152.347 227.068 c
b
149.747 226.468 m
149.747 226.965 150.15 227.368 150.647 227.368 c
151.144 227.368 151.547 226.965 151.547 226.468 c
151.547 225.971 151.144 225.568 150.647 225.568 c
150.15 225.568 149.747 225.971 149.747 226.468 c
b
152.347 224.268 m
152.347 224.765 152.75 225.168 153.247 225.168 c
153.744 225.168 154.147 224.765 154.147 224.268 c
154.147 223.771 153.744 223.368 153.247 223.368 c
152.75 223.368 152.347 223.771 152.347 224.268 c
b
149.747 218.668 m
149.747 219.165 150.15 219.568 150.647 219.568 c
151.144 219.568 151.547 219.165 151.547 218.668 c
151.547 218.171 151.144 217.768 150.647 217.768 c
150.15 217.768 149.747 218.171 149.747 218.668 c
b
152.547 217.468 m
152.547 217.965 152.95 218.368 153.447 218.368 c
153.944 218.368 154.347 217.965 154.347 217.468 c
154.347 216.971 153.944 216.568 153.447 216.568 c
152.95 216.568 152.547 216.971 152.547 217.468 c
b
155.147 217.468 m
155.147 217.965 155.55 218.368 156.047 218.368 c
156.544 218.368 156.947 217.965 156.947 217.468 c
156.947 216.971 156.544 216.568 156.047 216.568 c
155.55 216.568 155.147 216.971 155.147 217.468 c
b
152.347 212.268 m
152.347 212.765 152.75 213.168 153.247 213.168 c
153.744 213.168 154.147 212.765 154.147 212.268 c
154.147 211.771 153.744 211.368 153.247 211.368 c
152.75 211.368 152.347 211.771 152.347 212.268 c
b
152.347 208.668 m
152.347 209.165 152.75 209.568 153.247 209.568 c
153.744 209.568 154.147 209.165 154.147 208.668 c
154.147 208.171 153.744 207.768 153.247 207.768 c
152.75 207.768 152.347 208.171 152.347 208.668 c
b
136.047 226.668 m
170.647 226.668 l
188.046 215.468 m
222.046 215.468 l
239.046 202.863 m
274.046 202.863 l
S
204.146 199.068 m
204.146 199.565 204.549 199.968 205.046 199.968 c
205.543 199.968 205.946 199.565 205.946 199.068 c
205.946 198.571 205.543 198.168 205.046 198.168 c
204.549 198.168 204.146 198.571 204.146 199.068 c
b
206.946 199.068 m
206.946 199.565 207.349 199.968 207.846 199.968 c
208.343 199.968 208.746 199.565 208.746 199.068 c
208.746 198.571 208.343 198.168 207.846 198.168 c
207.349 198.168 206.946 198.571 206.946 199.068 c
b
204.146 202.468 m
204.146 202.965 204.549 203.368 205.046 203.368 c
205.543 203.368 205.946 202.965 205.946 202.468 c
205.946 201.971 205.543 201.568 205.046 201.568 c
204.549 201.568 204.146 201.971 204.146 202.468 c
b
201.546 205.068 m
201.546 205.565 201.949 205.968 202.446 205.968 c
202.943 205.968 203.346 205.565 203.346 205.068 c
203.346 204.571 202.943 204.168 202.446 204.168 c
201.949 204.168 201.546 204.571 201.546 205.068 c
b
203.946 207.268 m
203.946 207.765 204.349 208.168 204.846 208.168 c
205.343 208.168 205.746 207.765 205.746 207.268 c
205.746 206.771 205.343 206.368 204.846 206.368 c
204.349 206.368 203.946 206.771 203.946 207.268 c
b
206.946 207.268 m
206.946 207.765 207.349 208.168 207.846 208.168 c
208.343 208.168 208.746 207.765 208.746 207.268 c
208.746 206.771 208.343 206.368 207.846 206.368 c
207.349 206.368 206.946 206.771 206.946 207.268 c
b
201.346 209.268 m
201.346 209.765 201.749 210.168 202.246 210.168 c
202.743 210.168 203.146 209.765 203.146 209.268 c
203.146 208.771 202.743 208.368 202.246 208.368 c
201.749 208.368 201.346 208.771 201.346 209.268 c
b
201.346 211.068 m
201.346 211.565 201.749 211.968 202.246 211.968 c
202.743 211.968 203.146 211.565 203.146 211.068 c
203.146 210.571 202.743 210.168 202.246 210.168 c
201.749 210.168 201.346 210.571 201.346 211.068 c
b
204.146 211.268 m
204.146 211.765 204.549 212.168 205.046 212.168 c
205.543 212.168 205.946 211.765 205.946 211.268 c
205.946 210.771 205.543 210.368 205.046 210.368 c
204.549 210.368 204.146 210.771 204.146 211.268 c
b
206.946 212.668 m
206.946 213.165 207.349 213.568 207.846 213.568 c
208.343 213.568 208.746 213.165 208.746 212.668 c
208.746 212.171 208.343 211.768 207.846 211.768 c
207.349 211.768 206.946 212.171 206.946 212.668 c
b
206.946 214.068 m
206.946 214.565 207.349 214.968 207.846 214.968 c
208.343 214.968 208.746 214.565 208.746 214.068 c
208.746 213.571 208.343 213.168 207.846 213.168 c
207.349 213.168 206.946 213.571 206.946 214.068 c
b
204.146 214.068 m
204.146 214.565 204.549 214.968 205.046 214.968 c
205.543 214.968 205.946 214.565 205.946 214.068 c
205.946 213.571 205.543 213.168 205.046 213.168 c
204.549 213.168 204.146 213.571 204.146 214.068 c
b
201.546 214.068 m
201.546 214.565 201.949 214.968 202.446 214.968 c
202.943 214.968 203.346 214.565 203.346 214.068 c
203.346 213.571 202.943 213.168 202.446 213.168 c
201.949 213.168 201.546 213.571 201.546 214.068 c
b
198.546 212.668 m
198.546 213.165 198.949 213.568 199.446 213.568 c
199.943 213.568 200.346 213.165 200.346 212.668 c
200.346 212.171 199.943 211.768 199.446 211.768 c
198.949 211.768 198.546 212.171 198.546 212.668 c
b
198.746 215.468 m
198.746 215.965 199.149 216.368 199.646 216.368 c
200.144 216.368 200.546 215.965 200.546 215.468 c
200.546 214.971 200.144 214.568 199.646 214.568 c
199.149 214.568 198.746 214.971 198.746 215.468 c
b
196.146 216.868 m
196.146 217.365 196.549 217.768 197.046 217.768 c
197.544 217.768 197.946 217.365 197.946 216.868 c
197.946 216.371 197.544 215.968 197.046 215.968 c
196.549 215.968 196.146 216.371 196.146 216.868 c
b
201.346 221.268 m
201.346 221.765 201.749 222.168 202.246 222.168 c
202.743 222.168 203.146 221.765 203.146 221.268 c
203.146 220.771 202.743 220.368 202.246 220.368 c
201.749 220.368 201.346 220.771 201.346 221.268 c
b
204.346 221.068 m
204.346 221.565 204.749 221.968 205.246 221.968 c
205.743 221.968 206.146 221.565 206.146 221.068 c
206.146 220.571 205.743 220.168 205.246 220.168 c
204.749 220.168 204.346 220.571 204.346 221.068 c
b
206.946 221.268 m
206.946 221.765 207.349 222.168 207.846 222.168 c
208.343 222.168 208.746 221.765 208.746 221.268 c
208.746 220.771 208.343 220.368 207.846 220.368 c
207.349 220.368 206.946 220.771 206.946 221.268 c
b
203.946 218.268 m
203.946 218.765 204.349 219.168 204.846 219.168 c
205.343 219.168 205.746 218.765 205.746 218.268 c
205.746 217.771 205.343 217.368 204.846 217.368 c
204.349 217.368 203.946 217.771 203.946 218.268 c
b
209.346 215.868 m
209.346 216.365 209.749 216.768 210.246 216.768 c
210.743 216.768 211.146 216.365 211.146 215.868 c
211.146 215.371 210.743 214.968 210.246 214.968 c
209.749 214.968 209.346 215.371 209.346 215.868 c
b
212.146 215.868 m
212.146 216.365 212.549 216.768 213.046 216.768 c
213.544 216.768 213.946 216.365 213.946 215.868 c
213.946 215.371 213.544 214.968 213.046 214.968 c
212.549 214.968 212.146 215.371 212.146 215.868 c
b
209.346 224.068 m
209.346 224.565 209.749 224.968 210.246 224.968 c
210.743 224.968 211.146 224.565 211.146 224.068 c
211.146 223.571 210.743 223.168 210.246 223.168 c
209.749 223.168 209.346 223.571 209.346 224.068 c
b
209.346 228.668 m
209.346 229.165 209.749 229.568 210.246 229.568 c
210.743 229.568 211.146 229.165 211.146 228.668 c
211.146 228.171 210.743 227.768 210.246 227.768 c
209.749 227.768 209.346 228.171 209.346 228.668 c
b
206.746 230.468 m
206.746 230.965 207.149 231.368 207.646 231.368 c
208.144 231.368 208.546 230.965 208.546 230.468 c
208.546 229.971 208.144 229.568 207.646 229.568 c
207.149 229.568 206.746 229.971 206.746 230.468 c
b
203.946 230.468 m
203.946 230.965 204.349 231.368 204.846 231.368 c
205.343 231.368 205.746 230.965 205.746 230.468 c
205.746 229.971 205.343 229.568 204.846 229.568 c
204.349 229.568 203.946 229.971 203.946 230.468 c
b
204.146 233.468 m
204.146 233.965 204.549 234.368 205.046 234.368 c
205.543 234.368 205.946 233.965 205.946 233.468 c
205.946 232.971 205.543 232.568 205.046 232.568 c
204.549 232.568 204.146 232.971 204.146 233.468 c
b
201.146 232.068 m
201.146 232.565 201.549 232.968 202.046 232.968 c
202.544 232.968 202.946 232.565 202.946 232.068 c
202.946 231.571 202.544 231.168 202.046 231.168 c
201.549 231.168 201.146 231.571 201.146 232.068 c
b
203.346 238.668 m
203.346 239.165 203.749 239.568 204.246 239.568 c
204.743 239.568 205.146 239.165 205.146 238.668 c
205.146 238.171 204.743 237.768 204.246 237.768 c
203.749 237.768 203.346 238.171 203.346 238.668 c
b
198.546 227.468 m
198.546 227.965 198.949 228.368 199.446 228.368 c
199.943 228.368 200.346 227.965 200.346 227.468 c
200.346 226.971 199.943 226.568 199.446 226.568 c
198.949 226.568 198.546 226.971 198.546 227.468 c
b
201.346 227.068 m
201.346 227.565 201.749 227.968 202.246 227.968 c
202.743 227.968 203.146 227.565 203.146 227.068 c
203.146 226.571 202.743 226.168 202.246 226.168 c
201.749 226.168 201.346 226.571 201.346 227.068 c
b
203.946 226.268 m
203.946 226.765 204.349 227.168 204.846 227.168 c
205.343 227.168 205.746 226.765 205.746 226.268 c
205.746 225.771 205.343 225.368 204.846 225.368 c
204.349 225.368 203.946 225.771 203.946 226.268 c
b
206.546 227.468 m
206.546 227.965 206.949 228.368 207.446 228.368 c
207.943 228.368 208.346 227.965 208.346 227.468 c
208.346 226.971 207.943 226.568 207.446 226.568 c
206.949 226.568 206.546 226.971 206.546 227.468 c
b
252.746 195.468 m
252.746 195.965 253.149 196.368 253.646 196.368 c
254.143 196.368 254.546 195.965 254.546 195.468 c
254.546 194.971 254.143 194.568 253.646 194.568 c
253.149 194.568 252.746 194.971 252.746 195.468 c
b
255.746 195.668 m
255.746 196.166 256.149 196.568 256.646 196.568 c
257.143 196.568 257.546 196.166 257.546 195.668 c
257.546 195.171 257.143 194.768 256.646 194.768 c
256.149 194.768 255.746 195.171 255.746 195.668 c
b
258.346 195.668 m
258.346 196.166 258.749 196.568 259.246 196.568 c
259.743 196.568 260.146 196.166 260.146 195.668 c
260.146 195.171 259.743 194.768 259.246 194.768 c
258.749 194.768 258.346 195.171 258.346 195.668 c
b
255.746 190.868 m
255.746 191.365 256.149 191.768 256.646 191.768 c
257.143 191.768 257.546 191.365 257.546 190.868 c
257.546 190.371 257.143 189.968 256.646 189.968 c
256.149 189.968 255.746 190.371 255.746 190.868 c
b
258.346 190.669 m
258.346 191.165 258.749 191.568 259.246 191.568 c
259.743 191.568 260.146 191.165 260.146 190.669 c
260.146 190.171 259.743 189.768 259.246 189.768 c
258.749 189.768 258.346 190.171 258.346 190.669 c
b
263.746 202.868 m
263.746 203.365 264.149 203.768 264.646 203.768 c
265.143 203.768 265.546 203.365 265.546 202.868 c
265.546 202.371 265.143 201.968 264.646 201.968 c
264.149 201.968 263.746 202.371 263.746 202.868 c
b
260.946 202.868 m
260.946 203.365 261.349 203.768 261.846 203.768 c
262.343 203.768 262.746 203.365 262.746 202.868 c
262.746 202.371 262.343 201.968 261.846 201.968 c
261.349 201.968 260.946 202.371 260.946 202.868 c
b
258.146 202.87 m
258.146 203.367 258.549 203.77 259.046 203.77 c
259.543 203.77 259.946 203.367 259.946 202.87 c
259.946 202.373 259.543 201.97 259.046 201.97 c
258.549 201.97 258.146 202.373 258.146 202.87 c
b
255.346 202.844 m
255.346 203.341 255.749 203.744 256.246 203.744 c
256.743 203.744 257.146 203.341 257.146 202.844 c
257.146 202.346 256.743 201.944 256.246 201.944 c
255.749 201.944 255.346 202.346 255.346 202.844 c
b
252.746 202.868 m
252.746 203.365 253.149 203.768 253.646 203.768 c
254.143 203.768 254.546 203.365 254.546 202.868 c
254.546 202.371 254.143 201.968 253.646 201.968 c
253.149 201.968 252.746 202.371 252.746 202.868 c
b
249.946 202.868 m
249.946 203.365 250.349 203.768 250.846 203.768 c
251.343 203.768 251.746 203.365 251.746 202.868 c
251.746 202.371 251.343 201.968 250.846 201.968 c
250.349 201.968 249.946 202.371 249.946 202.868 c
b
260.746 207.868 m
260.746 208.365 261.149 208.768 261.646 208.768 c
262.143 208.768 262.546 208.365 262.546 207.868 c
262.546 207.371 262.143 206.968 261.646 206.968 c
261.149 206.968 260.746 207.371 260.746 207.868 c
b
258.146 207.868 m
258.146 208.365 258.549 208.768 259.046 208.768 c
259.543 208.768 259.946 208.365 259.946 207.868 c
259.946 207.371 259.543 206.968 259.046 206.968 c
258.549 206.968 258.146 207.371 258.146 207.868 c
b
255.346 207.868 m
255.346 208.365 255.749 208.768 256.246 208.768 c
256.743 208.768 257.146 208.365 257.146 207.868 c
257.146 207.371 256.743 206.968 256.246 206.968 c
255.749 206.968 255.346 207.371 255.346 207.868 c
b
252.663 207.895 m
252.663 208.392 253.066 208.795 253.563 208.795 c
254.06 208.795 254.463 208.392 254.463 207.895 c
254.463 207.397 254.06 206.995 253.563 206.995 c
253.066 206.995 252.663 207.397 252.663 207.895 c
b
249.946 207.949 m
249.946 208.447 250.349 208.849 250.846 208.849 c
251.343 208.849 251.746 208.447 251.746 207.949 c
251.746 207.452 251.343 207.049 250.846 207.049 c
250.349 207.049 249.946 207.452 249.946 207.949 c
b
247.346 210.068 m
247.346 210.565 247.749 210.968 248.246 210.968 c
248.743 210.968 249.146 210.565 249.146 210.068 c
249.146 209.571 248.743 209.168 248.246 209.168 c
247.749 209.168 247.346 209.571 247.346 210.068 c
b
255.546 211.668 m
255.546 212.165 255.949 212.568 256.446 212.568 c
256.943 212.568 257.346 212.165 257.346 211.668 c
257.346 211.171 256.943 210.768 256.446 210.768 c
255.949 210.768 255.546 211.171 255.546 211.668 c
b
258.146 211.668 m
258.146 212.165 258.549 212.568 259.046 212.568 c
259.543 212.568 259.946 212.165 259.946 211.668 c
259.946 211.171 259.543 210.768 259.046 210.768 c
258.549 210.768 258.146 211.171 258.146 211.668 c
b
257.946 217.468 m
257.946 217.965 258.349 218.368 258.846 218.368 c
259.343 218.368 259.746 217.965 259.746 217.468 c
259.746 216.971 259.343 216.568 258.846 216.568 c
258.349 216.568 257.946 216.971 257.946 217.468 c
b
255.546 214.868 m
255.546 215.365 255.949 215.768 256.446 215.768 c
256.943 215.768 257.346 215.365 257.346 214.868 c
257.346 214.371 256.943 213.968 256.446 213.968 c
255.949 213.968 255.546 214.371 255.546 214.868 c
b
252.746 214.868 m
252.746 215.365 253.149 215.768 253.646 215.768 c
254.143 215.768 254.546 215.365 254.546 214.868 c
254.546 214.371 254.143 213.968 253.646 213.968 c
253.149 213.968 252.746 214.371 252.746 214.868 c
b
255.346 227.468 m
255.346 227.965 255.749 228.368 256.246 228.368 c
256.743 228.368 257.146 227.965 257.146 227.468 c
257.146 226.971 256.743 226.568 256.246 226.568 c
255.749 226.568 255.346 226.971 255.346 227.468 c
b
152.965 301.313 m
152.965 306.313 l
206.631 306.313 l
206.631 301.348 l
208.214 301.313 m
208.214 306.313 l
261.881 306.313 l
261.881 301.348 l
S
BT
/F18 1 Tf
10 0 0 10 177.548 310.313 Tm
/GS3 gs
(*)Tj
5.3547 0.0255 TD
(**)Tj
/F16 1 Tf
-9.5033 -16.0071 TD
[(V)45(entilated)]TJ
4.8418 -0.0054 TD
-0.001 Tc
(Nonventilated)Tj
ET
/GS4 gs
154.909 164.818 m
154.909 161.818 l
209.284 164.818 m
209.284 161.818 l
263.909 164.818 m
263.909 161.818 l
117.472 164.559 m
283.159 164.559 l
S
BT
/F3 1 Tf
7.97 0 0 7.97 58.28 129.487 Tm
0 g
/GS2 gs
0 Tc
[(Fig.)-327.1(1.)-331.2(\261)-332.2(Plasma)-406.7(interleukin)-404.2(\(IL\)-8)-410.5(levels)-411(measured)-401.5(within)-409.6(24)-408.4(h)-410.5(after)]TJ
0 -1.0599 TD
[(admission)-542.3(in)-545.9(ventilated)-547.4(patients,)-543.3(nonventilate)11.6(d)-552.7(patients)-544.3(and)-547.5(control)]TJ
0 -1.067 TD
[(subjects.)-328.7(Bars)-331(represen)11.2(t)-334.6(mean)-331.3(values.)-322.2(*:)-332.5(p)]TJ
/F10 1 Tf
17.0146 0 TD
(<)Tj
/F3 1 Tf
0.5548 0 TD
[(0.01;)-327.2(**:)-330.4(p)]TJ
/F10 1 Tf
4.4457 0 TD
(<)Tj
/F3 1 Tf
0.5477 0 TD
(0.001.)Tj
/F18 1 Tf
10 0 0 10 429.664 770.801 Tm
0 0 0 1 k
/GS3 gs
(*)Tj
/F16 1 Tf
-9.425 -2.1612 TD
(75000)Tj
0 10 -10 0 319.559 624.802 Tm
[(L)30(ymphoproliferative response  cpm)]TJ
10 0 0 10 335.539 704.854 Tm
(50000)Tj
0.0125 -4.3807 TD
(25000)Tj
1.825 -4.4495 TD
(0)Tj
14.6383 -1.4873 TD
(Control)Tj
-0.1824 -1 TD
(subjects)Tj
ET
/GS4 gs
366.98 619.278 m
361.98 619.278 l
366.782 663.051 m
361.782 663.051 l
366.895 707.051 m
361.895 707.051 l
367.088 751.32 m
362.088 751.32 l
386.289 639.926 m
423.039 639.926 l
440.788 666.301 m
476.913 666.301 l
494.788 694.176 m
531.663 694.176 l
S
403.539 677.176 m
403.539 677.729 403.986 678.176 404.539 678.176 c
405.091 678.176 405.539 677.729 405.539 677.176 c
405.539 676.624 405.091 676.176 404.539 676.176 c
403.986 676.176 403.539 676.624 403.539 677.176 c
b
403.539 650.176 m
403.539 650.729 403.986 651.176 404.539 651.176 c
405.091 651.176 405.539 650.729 405.539 650.176 c
405.539 649.624 405.091 649.176 404.539 649.176 c
403.986 649.176 403.539 649.624 403.539 650.176 c
b
406.789 644.926 m
406.789 645.479 407.236 645.926 407.789 645.926 c
408.341 645.926 408.789 645.479 408.789 644.926 c
408.789 644.374 408.341 643.926 407.789 643.926 c
407.236 643.926 406.789 644.374 406.789 644.926 c
b
403.664 644.926 m
403.664 645.479 404.111 645.926 404.664 645.926 c
405.216 645.926 405.664 645.479 405.664 644.926 c
405.664 644.374 405.216 643.926 404.664 643.926 c
404.111 643.926 403.664 644.374 403.664 644.926 c
b
400.789 644.926 m
400.789 645.479 401.236 645.926 401.789 645.926 c
402.341 645.926 402.789 645.479 402.789 644.926 c
402.789 644.374 402.341 643.926 401.789 643.926 c
401.236 643.926 400.789 644.374 400.789 644.926 c
b
397.789 646.801 m
397.789 647.354 398.236 647.801 398.789 647.801 c
399.341 647.801 399.789 647.354 399.789 646.801 c
399.789 646.249 399.341 645.801 398.789 645.801 c
398.236 645.801 397.789 646.249 397.789 646.801 c
b
403.539 641.426 m
403.539 641.979 403.986 642.426 404.539 642.426 c
405.091 642.426 405.539 641.979 405.539 641.426 c
405.539 640.874 405.091 640.426 404.539 640.426 c
403.986 640.426 403.539 640.874 403.539 641.426 c
b
400.789 637.801 m
400.789 638.354 401.236 638.801 401.789 638.801 c
402.341 638.801 402.789 638.354 402.789 637.801 c
402.789 637.249 402.341 636.802 401.789 636.802 c
401.236 636.802 400.789 637.249 400.789 637.801 c
b
403.914 635.051 m
403.914 635.604 404.361 636.052 404.914 636.052 c
405.466 636.052 405.914 635.604 405.914 635.051 c
405.914 634.499 405.466 634.051 404.914 634.051 c
404.361 634.051 403.914 634.499 403.914 635.051 c
b
403.664 630.676 m
403.664 631.229 404.111 631.676 404.664 631.676 c
405.216 631.676 405.664 631.229 405.664 630.676 c
405.664 630.124 405.216 629.677 404.664 629.677 c
404.111 629.677 403.664 630.124 403.664 630.676 c
b
406.789 628.801 m
406.789 629.354 407.236 629.801 407.789 629.801 c
408.341 629.801 408.789 629.354 408.789 628.801 c
408.789 628.249 408.341 627.802 407.789 627.802 c
407.236 627.802 406.789 628.249 406.789 628.801 c
b
403.914 626.302 m
403.914 626.854 404.361 627.301 404.914 627.301 c
405.466 627.301 405.914 626.854 405.914 626.302 c
405.914 625.749 405.466 625.301 404.914 625.301 c
404.361 625.301 403.914 625.749 403.914 626.302 c
b
400.664 627.551 m
400.664 628.104 401.111 628.552 401.664 628.552 c
402.216 628.552 402.664 628.104 402.664 627.551 c
402.664 626.999 402.216 626.551 401.664 626.551 c
401.111 626.551 400.664 626.999 400.664 627.551 c
b
403.789 621.551 m
403.789 622.104 404.236 622.552 404.789 622.552 c
405.341 622.552 405.789 622.104 405.789 621.551 c
405.789 620.999 405.341 620.552 404.789 620.552 c
404.236 620.552 403.789 620.999 403.789 621.551 c
b
457.913 630.052 m
457.913 630.604 458.361 631.051 458.913 631.051 c
459.466 631.051 459.913 630.604 459.913 630.052 c
459.913 629.499 459.466 629.051 458.913 629.051 c
458.361 629.051 457.913 629.499 457.913 630.052 c
b
458.038 625.426 m
458.038 625.979 458.486 626.426 459.038 626.426 c
459.591 626.426 460.038 625.979 460.038 625.426 c
460.038 624.874 459.591 624.427 459.038 624.427 c
458.486 624.427 458.038 624.874 458.038 625.426 c
b
457.913 650.301 m
457.913 650.854 458.361 651.301 458.913 651.301 c
459.466 651.301 459.913 650.854 459.913 650.301 c
459.913 649.749 459.466 649.301 458.913 649.301 c
458.361 649.301 457.913 649.749 457.913 650.301 c
b
457.788 659.551 m
457.788 660.104 458.236 660.551 458.788 660.551 c
459.341 660.551 459.788 660.104 459.788 659.551 c
459.788 658.999 459.341 658.551 458.788 658.551 c
458.236 658.551 457.788 658.999 457.788 659.551 c
b
454.663 661.301 m
454.663 661.854 455.111 662.301 455.663 662.301 c
456.216 662.301 456.663 661.854 456.663 661.301 c
456.663 660.749 456.216 660.301 455.663 660.301 c
455.111 660.301 454.663 660.749 454.663 661.301 c
b
457.663 675.676 m
457.663 676.229 458.111 676.676 458.663 676.676 c
459.216 676.676 459.663 676.229 459.663 675.676 c
459.663 675.124 459.216 674.676 458.663 674.676 c
458.111 674.676 457.663 675.124 457.663 675.676 c
b
457.913 679.426 m
457.913 679.978 458.361 680.426 458.913 680.426 c
459.466 680.426 459.913 679.978 459.913 679.426 c
459.913 678.874 459.466 678.426 458.913 678.426 c
458.361 678.426 457.913 678.874 457.913 679.426 c
b
457.788 682.926 m
457.788 683.479 458.236 683.926 458.788 683.926 c
459.341 683.926 459.788 683.479 459.788 682.926 c
459.788 682.374 459.341 681.926 458.788 681.926 c
458.236 681.926 457.788 682.374 457.788 682.926 c
b
460.913 682.801 m
460.913 683.353 461.361 683.801 461.913 683.801 c
462.466 683.801 462.913 683.353 462.913 682.801 c
462.913 682.249 462.466 681.801 461.913 681.801 c
461.361 681.801 460.913 682.249 460.913 682.801 c
b
454.913 682.801 m
454.913 683.353 455.361 683.801 455.913 683.801 c
456.466 683.801 456.913 683.353 456.913 682.801 c
456.913 682.249 456.466 681.801 455.913 681.801 c
455.361 681.801 454.913 682.249 454.913 682.801 c
b
457.663 698.926 m
457.663 699.478 458.111 699.926 458.663 699.926 c
459.216 699.926 459.663 699.478 459.663 698.926 c
459.663 698.374 459.216 697.926 458.663 697.926 c
458.111 697.926 457.663 698.374 457.663 698.926 c
b
512.163 627.926 m
512.163 628.479 512.611 628.927 513.163 628.927 c
513.715 628.927 514.163 628.479 514.163 627.926 c
514.163 627.374 513.715 626.926 513.163 626.926 c
512.611 626.926 512.163 627.374 512.163 627.926 c
b
512.038 659.926 m
512.038 660.479 512.486 660.926 513.038 660.926 c
513.59 660.926 514.038 660.479 514.038 659.926 c
514.038 659.374 513.59 658.926 513.038 658.926 c
512.486 658.926 512.038 659.374 512.038 659.926 c
b
511.913 665.051 m
511.913 665.603 512.361 666.051 512.913 666.051 c
513.465 666.051 513.913 665.603 513.913 665.051 c
513.913 664.499 513.465 664.051 512.913 664.051 c
512.361 664.051 511.913 664.499 511.913 665.051 c
b
511.913 668.801 m
511.913 669.353 512.361 669.801 512.913 669.801 c
513.465 669.801 513.913 669.353 513.913 668.801 c
513.913 668.249 513.465 667.801 512.913 667.801 c
512.361 667.801 511.913 668.249 511.913 668.801 c
b
512.038 675.801 m
512.038 676.354 512.486 676.801 513.038 676.801 c
513.59 676.801 514.038 676.354 514.038 675.801 c
514.038 675.249 513.59 674.801 513.038 674.801 c
512.486 674.801 512.038 675.249 512.038 675.801 c
b
512.038 679.426 m
512.038 679.978 512.486 680.426 513.038 680.426 c
513.59 680.426 514.038 679.978 514.038 679.426 c
514.038 678.874 513.59 678.426 513.038 678.426 c
512.486 678.426 512.038 678.874 512.038 679.426 c
b
514.913 681.176 m
514.913 681.728 515.361 682.176 515.913 682.176 c
516.465 682.176 516.913 681.728 516.913 681.176 c
516.913 680.624 516.465 680.176 515.913 680.176 c
515.361 680.176 514.913 680.624 514.913 681.176 c
b
517.913 681.051 m
517.913 681.604 518.361 682.051 518.913 682.051 c
519.465 682.051 519.913 681.604 519.913 681.051 c
519.913 680.499 519.465 680.051 518.913 680.051 c
518.361 680.051 517.913 680.499 517.913 681.051 c
b
509.038 681.301 m
509.038 681.853 509.486 682.301 510.038 682.301 c
510.59 682.301 511.038 681.853 511.038 681.301 c
511.038 680.749 510.59 680.301 510.038 680.301 c
509.486 680.301 509.038 680.749 509.038 681.301 c
b
506.038 681.176 m
506.038 681.728 506.486 682.176 507.038 682.176 c
507.59 682.176 508.038 681.728 508.038 681.176 c
508.038 680.624 507.59 680.176 507.038 680.176 c
506.486 680.176 506.038 680.624 506.038 681.176 c
b
508.788 690.051 m
508.788 690.604 509.236 691.051 509.788 691.051 c
510.34 691.051 510.788 690.604 510.788 690.051 c
510.788 689.499 510.34 689.051 509.788 689.051 c
509.236 689.051 508.788 689.499 508.788 690.051 c
b
511.913 690.176 m
511.913 690.728 512.361 691.176 512.913 691.176 c
513.465 691.176 513.913 690.728 513.913 690.176 c
513.913 689.624 513.465 689.176 512.913 689.176 c
512.361 689.176 511.913 689.624 511.913 690.176 c
b
514.913 690.176 m
514.913 690.728 515.361 691.176 515.913 691.176 c
516.465 691.176 516.913 690.728 516.913 690.176 c
516.913 689.624 516.465 689.176 515.913 689.176 c
515.361 689.176 514.913 689.624 514.913 690.176 c
b
514.788 697.301 m
514.788 697.853 515.236 698.301 515.788 698.301 c
516.34 698.301 516.788 697.853 516.788 697.301 c
516.788 696.749 516.34 696.301 515.788 696.301 c
515.236 696.301 514.788 696.749 514.788 697.301 c
b
511.913 697.301 m
511.913 697.853 512.361 698.301 512.913 698.301 c
513.465 698.301 513.913 697.853 513.913 697.301 c
513.913 696.749 513.465 696.301 512.913 696.301 c
512.361 696.301 511.913 696.749 511.913 697.301 c
b
508.788 697.301 m
508.788 697.853 509.236 698.301 509.788 698.301 c
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[(ti)16.5(la)18.4(ti)16.5(on)-314.5(on)-308.8(im)15.7(mu)18.1(ne)-309.2(re)13.5(sp)20(on)21.2(se)13.9(s)-320.6(i)0(s)-306.7(l)0(a)12.8(r)20.4(ge)20.8(ly)-311.2(un)15.5(kn)21.2(ow)17.3(n,)-314.1(bu)21.2(t)-321.8(r)0(e)19.2(-)]TJ
0 -1.0471 TD
[(po)15.5(rt)17.3(s)-229.6(i)0(n)-220.2(l)0(a)18.4(b)0(o)21.2(r)0(a)13.5(t)0(o)18.9(r)0(y)-219.4(a)0(n)15.1(i)13.9(ma)12(ls)-215.7(in)13.2(di)18.8(ca)20.4(te)-220.6(th)18.9(at)-220.6(it)-222.5(ca)20.4(n)-228.4(c)0(h)15.1(a)0(n)20.8(g)0(e)-223.9(l)0(o)18.8(c)0(a)20.4(l)]TJ
0 -1.0527 TD
[(as)-447(we)16.9(ll)-444.5(as)-441.3(sy)14.4(st)17.7(em)17.7(ic)-442.5(in)13.2(fl)17.3(am)17.7(ma)17.7(to)18.9(ry)-447(re)19.2(sp)14.4(on)21.2(se)13.9(s)-451.5([)0(2)19.6(8].)-453.1(As)-467.6(a)]TJ
0 -1.0471 TD
[(resul)-9.4(t,)-345(a)-342.6(possi)-8.6(ble)-346.5(influence)-355.9(of)-344.6(mecha)-8.2(nical)-350.8(ventilat)-10.7(ion)-346.1(on)]TJ
0 -1.0527 TD
[(the)-443.3(immun)-12.5(e)-439.3(respon)-7.8(ses)-443.2(of)-441.3(ventilated)-450.8(patients)-447.7(cannot)-445.9(be)]TJ
0 -1.0471 TD
[(exc)-8.8(luded)-291.1(from)-299.6(this)-293.5(study)55.2(.)-290.6(However)24.2(,)-290.6(samp)-7.8(les)-296.5(taken)-297.2(in)-288.4(the)]TJ
0 -1.0527 TD
[(acu)-8.8(te)-482.3(phase)-489.5(were)-487.4(collected)-493.6(within)-488(the)-483.1(firs)-9.8(t)-481.2(2)0(4)-485.2(h)-484.5(after)]TJ
0 -1.0471 TD
[(mecha)-8.2(nical)-419.1(ventilat)-10.7(ion)-408.7(was)-417.5(initiated,)-418.3(in)-413.6(the)-409.1(maj)-8.2(ority)-414.2(of)]TJ
0 -1.0528 TD
[(cases)-343.2(even)-339.6(wi)-7.8(thin)-337.9(2\2616)-338(h.)-336.9(T)57.7(o)-336.5(the)-335.1(author)-9(s)]TJ
/F11 1 Tf
16.2864 0 TD
(')Tj
/F3 1 Tf
0.552 0 TD
[(k)-6.5(nowledge,)-343.6(no)]TJ
-16.8383 -1.0527 TD
[(data)-262.3(a)-6.9(r)0(e)-259.6(available)-266(in)-260(the)-261.2(literat)-11.6(ure,)-260.7(addres)-8.2(sing)-262.7(the)-261.2(kinetics)]TJ
0 -1.0471 TD
[(of)-247.8(immune)-247(respon)-7.8(ses)-244.1(durin)-7.8(g)-239.8(the)-244.1(first)-246.3(hou)-8(rs)-243.3(of)-242.1(mecha)-8.2(nical)]TJ
0 -1.0528 TD
[(ven)-8.4(tilation.)-326.1(Howeve)-13.2(r)31.8(,)-319.1(it)-325(is)-318.1(u)-6.5(nlikely)-325.9(that)-326.9(mechanical)-330.5(ven-)]TJ
0 -1.0471 TD
[(tilati)-11.2(on-in)-7.8(duced)-272.1(changes)-275.2(in)-271.4(immune)-275.4(respon)-7.8(ses)-272.5(in)-265.7(the)-272.5(cur-)]TJ
0 -1.0528 TD
[(rent)-274.9(pati)-8.2(ent)-272.5(group)-272.9(durin)-7.8(g)-268.2(this)-276.5(short)-276.4(time)-273.1(inte)-8.2(rval)-274.9(between)]TJ
0 -1.0471 TD
[(the)-409.1(initiation)-415(of)-401.5(mecha)-8.2(nical)-407.7(venti)-9(lation)-404.8(and)-406.7(blood)-410.2(sam-)]TJ
0 -1.0527 TD
[(plin)-7.8(g.)]TJ
1.0015 -1.0471 TD
[(As)16.1(th)13.2(ma)-380.7(is)-380.7(ch)15.1(ar)19.2(ac)20.4(te)12.8(ri)17.3(ze)20.4(d)-393.4(b)0(y)-377.1(a)-393.8(re)19.2(la)18.4(ti)16.5(ve)-383.2(in)18.9(cr)19.2(ea)14.7(se)-378.7(in)-385.2(pr)19.6(o-)]TJ
-1.0015 -1.0527 TD
[(du)15.5(ct)18.4(io)18.8(n)-399.1(o)0(f)-390.1(T)12.2(h2)-388.5(cy)20.8(to)13.2(ki)18.9(ne)20.8(s)-400.3(\()]TJ
/F5 1 Tf
10.9543 0 TD
[(e.)21.2(g.)]TJ
/F3 1 Tf
1.8039 0 TD
[(IL)15.5(-4)19.6(\))-400.7(a)0(n)20.8(d)-399.1(a)-393.8(r)0(e)13.5(l)0(a)18.5(t)0(i)16.5(v)0(e)-388.9(s)0(u)20(p)0(-)]TJ
-12.7582 -1.0471 TD
[(pr)13.9(es)19.6(si)17.7(on)-297.4(of)-293.3(pr)14(od)21.2(uc)15.1(ti)16.5(on)-291.7(of)-299(Th)17.1(1)-302.4(c)0(y)15.1(t)0(o)18.9(k)0(i)18.9(n)0(e)15.1(s)-303.6(\()]TJ
/F5 1 Tf
16.5424 0 TD
[(e.)15.5(g.)]TJ
/F3 1 Tf
1.7129 0 TD
[(IF)14.7(N-)]TJ
/F8 1 Tf
1.8836 0 TD
(c)Tj
/F3 1 Tf
0.4894 0 TD
0.304 Tc
[(\)[)304(1)318(5)304(,)]TJ
-20.6282 -1.0528 TD
0 Tc
[(17].)-408.3(Conside)-8.3(ring)-405.4(the)-403.4(associ)-10.1(ation)-407.3(between)-411.2(RSV)-402.8(bronch-)]TJ
T*
[(ioliti)-10.8(s)-462.9(and)-469.3(the)-466(subseq)-7.4(uent)-472.5(develo)-7.8(pment)-470.7(of)-464.1(asthm)-10.9(a,)-462.5(the)]TJ
0 -1.0471 TD
[(possi)-8.6(ble)-392(skewing)-394.5(of)-390.1(the)-392(Th1/Th2)-391.5(cytoki)-9.7(ne)-388.9(balanc)-8.2(e)-388.1(was)]TJ
0 -1.0527 TD
[(inves)-7.8(tigated)-360.4(by)-354.3(calculating)-361(IL-4/I)-10.2(FN-)]TJ
/F8 1 Tf
15.1312 0 TD
(c)Tj
/F3 1 Tf
0.8536 0 TD
[(ratios)-359.7([29].)-353.8(IL-4/)]TJ
-15.9848 -1.0471 TD
(IFN-)Tj
/F8 1 Tf
1.9234 0 TD
(c)Tj
/F3 1 Tf
0.8934 0 TD
[(ratios)-399.5(in)-390.9(both)-398.1(patient)-400.2(groups)-394.3(wer)-8.2(e)-393.8(normal)-399.1(in)-390.9(the)]TJ
-2.8168 -1.0527 TD
[(acu)-8.8(te)-374.2(and)-372.6(c)-6.9(onvalescent)-385.8(phase.)-376.1(However)18.5(,)-370.3(I)0(L)-7.2(-4/IFN-)]TJ
/F8 1 Tf
20.8445 0 TD
(c)Tj
/F3 1 Tf
0.8707 0 TD
(ra-)Tj
-21.7151 -1.0471 TD
[(tios)-322(could)-319.6(not)-317.6(be)-314.9(calculated)-324.1(for)-318.5(venti)-9(lated)-316.7(pati)-8.2(ents)-314.3(in)-316.9(the)]TJ
0 -1.0528 TD
[(acu)-8.8(te)-368.5(phase.)-376.1(R)]TJ
6.974 0 0 6.974 369.184 311.301 Tm
0.0001 Tc
[(OMA)-11.9(N)]TJ
/F5 1 Tf
9.963 0 0 9.963 394.129 311.301 Tm
0 Tc
[(et)-374.2(al.)]TJ
/F3 1 Tf
2.4697 0 TD
[([13])-376.1(report)-10.6(ed)-371.8(increased)-377.8(IL-4/)]TJ
-10.9828 -1.0471 TD
(IFN-)Tj
/F8 1 Tf
1.9234 0 TD
(c)Tj
/F3 1 Tf
1.0015 0 TD
[(rati)-9.8(os)-503.5(after)]TJ
/F5 1 Tf
4.9963 0 TD
[(in)-504.7(vitr)24.7(o)]TJ
/F3 1 Tf
3.6135 0 TD
[(stimul)-10.4(ation)-509.7(with)-506.8(pokew)-8.1(eed)]TJ
-11.5347 -1.0528 TD
[(mito)-11(gen)-310(in)-316.9(RSV)80.9(-infected)-323.3(children)-320.6(with)-313.3(low)-8.6(er)-310.8(respi)-9.4(ratory)]TJ
0 -1.0471 TD
[(tract)-324(symp)-7.4(toms.)-323.1(This)-323.7(apparen)-8.1(t)-316.1(contr)-8.2(adiction)-327(may)-318.8(be)-320.6(due)]TJ
0 -1.0528 TD
[(to)-254.3(d)-6.5(i)0(f)11.6(ferent)-261.3(cultu)-9(re)-253.9(condition)-8.7(s)-252.3(and)-258.8(a)-251.6(higher)-259.3(media)-10.1(n)-251.2(age)-253.5(in)]TJ
T*
[(thei)-8.2(r)-332.4(pati)-8.2(ent)-335.1(group.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-388.1(a)0(s)19.6(s)0(o)20(c)0(i)12.8(a)0(t)18.4(i)0(o)18.9(n)-382(fo)13.9(un)21.2(d)-382(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-387.7(in)18.9(cr)19.2(ea)14.7(se)19.6(d)-382(p)0(l)13.2(a)0(s)19.6(m)0(a)-375(I)0(L)15.5(-)0(8)]TJ
-1.0015 -1.0528 TD
[(le)12.8(ve)20.8(ls)-289.6(an)15.1(d)-296.7(s)0(e)13.9(v)0(e)20.8(r)0(e)-293.8(R)11.6(SV)-294.9(br)19.6(on)15.5(ch)20.8(io)18.9(li)16.5(ti)16.5(s)-297.9(i)0(s)-289.6(s)0(i)17.7(m)0(i)15.7(l)0(a)12.8(r)-298.3(to)-288.4(th)18.8(e)-302.8(f)0(i)17.3(n)0(d)21.2(-)]TJ
0 -1.0471 TD
[(in)13.2(gs)-213.3(by)-217.8(S)]TJ
6.974 0 0 6.974 345.373 227.622 Tm
0.0001 Tc
[(HU)21.6(TE)]TJ
/F5 1 Tf
9.963 0 0 9.963 365.896 227.622 Tm
0 Tc
[(et)-220.6(al)18.9(.)]TJ
/F3 1 Tf
2.151 0 TD
[([3)13.9(0])-225.1(who)-239.5(demon)-7.4(stra)-8.6(ted)-238.4(an)-235.2(associ)-10.1(ation)]TJ
-7.8302 -1.0528 TD
[(betw)-9.8(een)-321.8(incre)-8.6(ased)-323.7(serum)-328.8(IL)-7.2(-8)-321.8(levels)-330(and)-321.4(severe)-332.9(asthma.)]TJ
0 -1.0471 TD
[(How)-10.2(ever)28.7(,)-398.7(incre)-8.6(ased)-403.4(IL-8)-403(plasma)-410.4(levels)-404(are)-403(not)-403(specific)]TJ
0 -1.0527 TD
[(for)-267.3(RSV)-266.2(disease,)-267.8(since)-270(increased)-269.7(plasma)-268.2(IL-8)-266.4(levels)-267.4(have)]TJ
0 -1.0471 TD
[(bee)-8.8(n)-342.2(sugges)-7.4(ted)-346.5(to)-345.3(play)-347.3(a)-342.6(role)-348.9(in)-345.3(various)-346.7(respi)-9.4(ratory)-352(dis-)]TJ
0 -1.0527 TD
[(eases,)-280.9(possi)-8.6(bly)-272.1(by)-274.7(simil)-9.6(ar)-276.7(mechanism)-12.2(s,)-269.8(incl)-8.2(uding)-279.3(neutro-)]TJ
0 -1.0471 TD
[(phil)-286.7(and)-281.5(eosin)-7.8(ophil)-281.7(attr)-9.8(action,)-283.7(IgE-m)-8.6(ediat)-9.4(ed)-280.8(lung)-284.3(disease)]TJ
0 -1.0527 TD
[(and)-338.4(virus-ind)-10.3(uced)-339.6(respirato)-11.1(ry)-333.2(infla)-10.6(mmation)-341.2([4,)-333.6(31\2613)-8.7(5].)]TJ
1.0015 -1.0471 TD
[(Du)11.6(ri)17.3(ng)-337.3(th)18.8(e)-354(p)0(a)20.8(s)0(t)-340.8(f)0(e)13.5(w)-346.1(de)15.1(ca)20.4(de)15.1(s,)-338.1(da)15.1(ta)-340.1(ha)15.1(ve)-337.7(be)15.1(co)20.8(me)-340.8(av)15.1(ai)18.4(l-)]TJ
-1.0015 -1.0527 TD
[(ab)15.1(le)-192.1(in)13.2(di)18.9(ca)20.4(ti)16.5(ng)-195(th)18.9(at)-197.8(R)11.6(S)0(V)-198.2(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(o)13.2(l)13.9(it)16.5(is)-198.6(ca)20.4(n)-205.6(b)0(e)-189.7(c)0(o)15.1(n)0(s)20(i)0(d)13.2(e)0(r)19.2(e)0(d)-195.4(a)0(n)]TJ
T*
[(im)15.7(mu)12.4(ne)20.8(-m)16.5(ed)15.1(ia)18.5(te)18.4(d)-359.3(d)0(i)18.9(s)0(e)13.9(a)0(s)19.6(e)-359.7([4)13.9(].)-366.9(Ear)-8.4(ly)-368.1(tri)-8.6(als)-370.5(with)-375.9(a)-371.1(forma-)]TJ
0 -1.0471 TD
[(lin-)-9.4(inactivat)-11.9(ed)-212.5(RSV)-215(vaccin)-8.2(e)-211.7(resul)-9.4(ting)-212.7(in)-214.5(enhanced)-224(disease)]TJ
/F16 1 Tf
0 9.7 -9.7 0 75.071 671.3 Tm
0 0 0 1 k
/GS3 gs
(Interferon-)Tj
/F21 1 Tf
3.783 0 TD
(g)Tj
/F16 1 Tf
0.411 0 TD
(  pg\341mL)Tj
0 7.76 -7.76 0 72.872 738.51 Tm
(-1)Tj
9.7 0 0 9.7 79.237 770.4 Tm
(10000)Tj
ET
0 0 0 1 K
0 J 0 j 0.485 w 3.864 M []0 d
/GS4 gs
1 i 
110.276 773.31 m
110.276 639.937 l
110.276 640.074 m
104.699 640.074 l
110.226 683.829 m
104.649 683.829 l
110.265 728.448 m
104.688 728.448 l
110.304 773.26 m
104.726 773.26 l
S
BT
9.7 0 0 9.7 83.844 725.902 Tm
/GS3 gs
(1000)Tj
0.471 -4.6 TD
(100)Tj
0.379 -4.4125 TD
(10)Tj
ET
/GS4 gs
145.318 633.632 m
145.318 630.115 l
195.273 633.632 m
195.273 630.115 l
253.109 633.632 m
253.109 630.115 l
111.247 633.632 m
277.099 633.632 l
127.979 657.154 m
163.869 657.154 l
181.814 705.411 m
216.976 705.411 l
234.679 703.714 m
270.084 703.714 l
S
130.768 657.154 m
130.768 657.69 131.202 658.124 131.738 658.124 c
132.273 658.124 132.708 657.69 132.708 657.154 c
132.708 656.618 132.273 656.184 131.738 656.184 c
131.202 656.184 130.768 656.618 130.768 657.154 c
b
133.799 657.154 m
133.799 657.69 134.233 658.124 134.769 658.124 c
135.305 658.124 135.739 657.69 135.739 657.154 c
135.739 656.618 135.305 656.184 134.769 656.184 c
134.233 656.184 133.799 656.618 133.799 657.154 c
b
136.709 657.154 m
136.709 657.69 137.143 658.124 137.679 658.124 c
138.215 658.124 138.649 657.69 138.649 657.154 c
138.649 656.618 138.215 656.184 137.679 656.184 c
137.143 656.184 136.709 656.618 136.709 657.154 c
b
139.498 657.154 m
139.498 657.69 139.932 658.124 140.468 658.124 c
141.003 658.124 141.438 657.69 141.438 657.154 c
141.438 656.618 141.003 656.184 140.468 656.184 c
139.932 656.184 139.498 656.618 139.498 657.154 c
b
142.286 657.154 m
142.286 657.69 142.721 658.124 143.256 658.124 c
143.792 658.124 144.227 657.69 144.227 657.154 c
144.227 656.618 143.792 656.184 143.256 656.184 c
142.721 656.184 142.286 656.618 142.286 657.154 c
b
145.075 657.165 m
145.075 657.701 145.51 658.135 146.045 658.135 c
146.581 658.135 147.015 657.701 147.015 657.165 c
147.015 656.63 146.581 656.195 146.045 656.195 c
145.51 656.195 145.075 656.63 145.075 657.165 c
b
147.864 657.154 m
147.864 657.69 148.298 658.124 148.834 658.124 c
149.37 658.124 149.804 657.69 149.804 657.154 c
149.804 656.618 149.37 656.184 148.834 656.184 c
148.298 656.184 147.864 656.618 147.864 657.154 c
b
150.653 657.154 m
150.653 657.69 151.087 658.124 151.623 658.124 c
152.158 658.124 152.593 657.69 152.593 657.154 c
152.593 656.618 152.158 656.184 151.623 656.184 c
151.087 656.184 150.653 656.618 150.653 657.154 c
b
153.563 657.275 m
153.563 657.811 153.997 658.245 154.533 658.245 c
155.068 658.245 155.503 657.811 155.503 657.275 c
155.503 656.74 155.068 656.305 154.533 656.305 c
153.997 656.305 153.563 656.74 153.563 657.275 c
b
156.473 657.154 m
156.473 657.69 156.907 658.124 157.443 658.124 c
157.978 658.124 158.413 657.69 158.413 657.154 c
158.413 656.618 157.978 656.184 157.443 656.184 c
156.907 656.184 156.473 656.618 156.473 657.154 c
b
159.261 657.275 m
159.261 657.811 159.696 658.245 160.231 658.245 c
160.767 658.245 161.201 657.811 161.201 657.275 c
161.201 656.74 160.767 656.305 160.231 656.305 c
159.696 656.305 159.261 656.74 159.261 657.275 c
b
144.954 703.956 m
144.954 704.492 145.388 704.926 145.924 704.926 c
146.46 704.926 146.894 704.492 146.894 703.956 c
146.894 703.42 146.46 702.986 145.924 702.986 c
145.388 702.986 144.954 703.42 144.954 703.956 c
b
142.286 704.684 m
142.286 705.219 142.721 705.654 143.256 705.654 c
143.792 705.654 144.227 705.219 144.227 704.684 c
144.227 704.148 143.792 703.714 143.256 703.714 c
142.721 703.714 142.286 704.148 142.286 704.684 c
b
198.546 698.5 m
198.546 699.036 198.981 699.47 199.516 699.47 c
200.052 699.47 200.486 699.036 200.486 698.5 c
200.486 697.964 200.052 697.53 199.516 697.53 c
198.981 697.53 198.546 697.964 198.546 698.5 c
b
201.456 699.227 m
201.456 699.763 201.891 700.197 202.426 700.197 c
202.962 700.197 203.396 699.763 203.396 699.227 c
203.396 698.692 202.962 698.257 202.426 698.257 c
201.891 698.257 201.456 698.692 201.456 699.227 c
b
198.789 702.38 m
198.789 702.915 199.223 703.35 199.759 703.35 c
200.295 703.35 200.729 702.915 200.729 702.38 c
200.729 701.844 200.295 701.41 199.759 701.41 c
199.223 701.41 198.789 701.844 198.789 702.38 c
b
201.214 705.047 m
201.214 705.583 201.648 706.017 202.184 706.017 c
202.72 706.017 203.154 705.583 203.154 705.047 c
203.154 704.512 202.72 704.077 202.184 704.077 c
201.648 704.077 201.214 704.512 201.214 705.047 c
b
195.758 704.32 m
195.758 704.855 196.192 705.29 196.728 705.29 c
197.263 705.29 197.698 704.855 197.698 704.32 c
197.698 703.784 197.263 703.35 196.728 703.35 c
196.192 703.35 195.758 703.784 195.758 704.32 c
b
192.848 705.654 m
192.848 706.189 193.282 706.624 193.818 706.624 c
194.353 706.624 194.788 706.189 194.788 705.654 c
194.788 705.118 194.353 704.684 193.818 704.684 c
193.282 704.684 192.848 705.118 192.848 705.654 c
b
198.546 707.108 m
198.546 707.644 198.981 708.078 199.516 708.078 c
200.052 708.078 200.486 707.644 200.486 707.108 c
200.486 706.573 200.052 706.139 199.516 706.139 c
198.981 706.139 198.546 706.573 198.546 707.108 c
b
201.456 710.14 m
201.456 710.675 201.891 711.11 202.426 711.11 c
202.962 711.11 203.396 710.675 203.396 710.14 c
203.396 709.604 202.962 709.17 202.426 709.17 c
201.891 709.17 201.456 709.604 201.456 710.14 c
b
198.546 710.867 m
198.546 711.403 198.981 711.837 199.516 711.837 c
200.052 711.837 200.486 711.403 200.486 710.867 c
200.486 710.332 200.052 709.897 199.516 709.897 c
198.981 709.897 198.546 710.332 198.546 710.867 c
b
195.758 712.686 m
195.758 713.222 196.192 713.656 196.728 713.656 c
197.263 713.656 197.698 713.222 197.698 712.686 c
197.698 712.15 197.263 711.716 196.728 711.716 c
196.192 711.716 195.758 712.15 195.758 712.686 c
b
251.533 689.285 m
251.533 689.821 251.967 690.255 252.503 690.255 c
253.038 690.255 253.473 689.821 253.473 689.285 c
253.473 688.749 253.038 688.315 252.503 688.315 c
251.967 688.315 251.533 688.749 251.533 689.285 c
b
254.443 691.346 m
254.443 691.882 254.877 692.316 255.413 692.316 c
255.948 692.316 256.383 691.882 256.383 691.346 c
256.383 690.81 255.948 690.376 255.413 690.376 c
254.877 690.376 254.443 690.81 254.443 691.346 c
b
248.623 690.982 m
248.623 691.518 249.057 691.952 249.593 691.952 c
250.128 691.952 250.563 691.518 250.563 690.982 c
250.563 690.447 250.128 690.012 249.593 690.012 c
249.057 690.012 248.623 690.447 248.623 690.982 c
b
251.411 696.075 m
251.411 696.611 251.846 697.045 252.381 697.045 c
252.917 697.045 253.351 696.611 253.351 696.075 c
253.351 695.539 252.917 695.105 252.381 695.105 c
251.846 695.105 251.411 695.539 251.411 696.075 c
b
254.321 696.56 m
254.321 697.095 254.756 697.53 255.291 697.53 c
255.827 697.53 256.261 697.095 256.261 696.56 c
256.261 696.024 255.827 695.59 255.291 695.59 c
254.756 695.59 254.321 696.024 254.321 696.56 c
b
257.11 697.409 m
257.11 697.944 257.544 698.379 258.08 698.379 c
258.616 698.379 259.05 697.944 259.05 697.409 c
259.05 696.873 258.616 696.438 258.08 696.438 c
257.544 696.438 257.11 696.873 257.11 697.409 c
b
248.744 696.802 m
248.744 697.338 249.178 697.772 249.714 697.772 c
250.249 697.772 250.684 697.338 250.684 696.802 c
250.684 696.267 250.249 695.832 249.714 695.832 c
249.178 695.832 248.744 696.267 248.744 696.802 c
b
251.533 700.076 m
251.533 700.612 251.967 701.046 252.503 701.046 c
253.038 701.046 253.473 700.612 253.473 700.076 c
253.473 699.54 253.038 699.106 252.503 699.106 c
251.967 699.106 251.533 699.54 251.533 700.076 c
b
248.501 701.41 m
248.501 701.946 248.936 702.38 249.471 702.38 c
250.007 702.38 250.441 701.946 250.441 701.41 c
250.441 700.874 250.007 700.44 249.471 700.44 c
248.936 700.44 248.501 700.874 248.501 701.41 c
b
248.623 706.381 m
248.623 706.917 249.057 707.351 249.593 707.351 c
250.128 707.351 250.563 706.917 250.563 706.381 c
250.563 705.845 250.128 705.411 249.593 705.411 c
249.057 705.411 248.623 705.845 248.623 706.381 c
b
251.533 705.775 m
251.533 706.31 251.967 706.745 252.503 706.745 c
253.038 706.745 253.473 706.31 253.473 705.775 c
253.473 705.239 253.038 704.805 252.503 704.805 c
251.967 704.805 251.533 705.239 251.533 705.775 c
b
254.321 706.139 m
254.321 706.674 254.756 707.108 255.291 707.108 c
255.827 707.108 256.261 706.674 256.261 706.139 c
256.261 705.603 255.827 705.168 255.291 705.168 c
254.756 705.168 254.321 705.603 254.321 706.139 c
b
257.353 706.866 m
257.353 707.402 257.787 707.836 258.323 707.836 c
258.858 707.836 259.293 707.402 259.293 706.866 c
259.293 706.33 258.858 705.896 258.323 705.896 c
257.787 705.896 257.353 706.33 257.353 706.866 c
b
254.564 719.597 m
254.564 720.133 254.998 720.567 255.534 720.567 c
256.069 720.567 256.504 720.133 256.504 719.597 c
256.504 719.062 256.069 718.627 255.534 718.627 c
254.998 718.627 254.564 719.062 254.564 719.597 c
b
251.29 716.445 m
251.29 716.98 251.724 717.415 252.26 717.415 c
252.796 717.415 253.23 716.98 253.23 716.445 c
253.23 715.909 252.796 715.475 252.26 715.475 c
251.724 715.475 251.29 715.909 251.29 716.445 c
b
248.623 718.506 m
248.623 719.042 249.057 719.476 249.593 719.476 c
250.128 719.476 250.563 719.042 250.563 718.506 c
250.563 717.97 250.128 717.536 249.593 717.536 c
249.057 717.536 248.623 717.97 248.623 718.506 c
b
251.411 724.811 m
251.411 725.347 251.846 725.781 252.381 725.781 c
252.917 725.781 253.351 725.347 253.351 724.811 c
253.351 724.275 252.917 723.841 252.381 723.841 c
251.846 723.841 251.411 724.275 251.411 724.811 c
b
254.443 670.915 m
254.443 671.45 254.877 671.884 255.413 671.884 c
255.948 671.884 256.383 671.45 256.383 670.915 c
256.383 670.379 255.948 669.945 255.413 669.945 c
254.877 669.945 254.443 670.379 254.443 670.915 c
b
251.654 670.855 m
251.654 671.391 252.088 671.825 252.624 671.825 c
253.159 671.825 253.594 671.391 253.594 670.855 c
253.594 670.319 253.159 669.885 252.624 669.885 c
252.088 669.885 251.654 670.319 251.654 670.855 c
b
248.744 670.894 m
248.744 671.43 249.178 671.864 249.714 671.864 c
250.249 671.864 250.684 671.43 250.684 670.894 c
250.684 670.358 250.249 669.924 249.714 669.924 c
249.178 669.924 248.744 670.358 248.744 670.894 c
b
251.29 735.117 m
251.29 735.653 251.724 736.087 252.26 736.087 c
252.796 736.087 253.23 735.653 253.23 735.117 c
253.23 734.581 252.796 734.147 252.26 734.147 c
251.724 734.147 251.29 734.581 251.29 735.117 c
b
251.411 738.512 m
251.411 739.048 251.846 739.482 252.381 739.482 c
252.917 739.482 253.351 739.048 253.351 738.512 c
253.351 737.976 252.917 737.542 252.381 737.542 c
251.846 737.542 251.411 737.976 251.411 738.512 c
b
251.169 741.786 m
251.169 742.321 251.603 742.756 252.139 742.756 c
252.675 742.756 253.109 742.321 253.109 741.786 c
253.109 741.25 252.675 740.816 252.139 740.816 c
251.603 740.816 251.169 741.25 251.169 741.786 c
b
248.501 744.332 m
248.501 744.868 248.936 745.302 249.471 745.302 c
250.007 745.302 250.441 744.868 250.441 744.332 c
250.441 743.796 250.007 743.362 249.471 743.362 c
248.936 743.362 248.501 743.796 248.501 744.332 c
b
BT
/F18 1 Tf
9.7 0 0 9.7 168.271 755.204 Tm
/GS3 gs
(**)Tj
ET
/GS4 gs
146.386 751.243 m
146.386 754.638 l
200.706 754.638 l
200.706 750.758 l
S
BT
/F16 1 Tf
9.7 0 0 9.7 67.249 770.4 Tm
/GS3 gs
(a\))Tj
0 9.7 -9.7 0 75.616 503.491 Tm
(IL-4  pg\341mL)Tj
0 7.76 -7.76 0 73.416 543.726 Tm
(-1)Tj
ET
/GS4 gs
145.89 449.333 m
145.89 445.817 l
195.844 449.333 m
195.844 445.817 l
253.681 449.333 m
253.681 445.817 l
111.818 449.333 m
277.89 449.333 l
S
BT
9.7 0 0 9.7 67.821 599.924 Tm
/GS3 gs
(b\))Tj
ET
/GS4 gs
110.363 603.077 m
110.363 454.183 l
S
BT
9.7 0 0 9.7 127.924 433.813 Tm
/GS3 gs
[(V)45(entilated)-805.1(Nonventilated)-1991.2(Control)]TJ
11.4123 -1 TD
(subjects)Tj
ET
/GS4 gs
110.473 602.83 m
105.259 602.83 l
110.446 553.371 m
105.232 553.371 l
110.446 503.912 m
105.232 503.912 l
110.424 454.453 m
105.21 454.453 l
S
BT
9.7 0 0 9.7 89.101 599.803 Tm
/GS3 gs
(100)Tj
0.4675 -5.0625 TD
(10)Tj
0.5495 -5.1625 TD
(1)Tj
-0.6399 -5.0125 TD
(0.1)Tj
ET
/GS4 gs
128.308 502.925 m
166.138 502.925 l
S
201.503 550.293 m
201.503 550.829 201.937 551.263 202.473 551.263 c
203.008 551.263 203.443 550.829 203.443 550.293 c
203.443 549.757 203.008 549.323 202.473 549.323 c
201.937 549.323 201.503 549.757 201.503 550.293 c
b
201.22 566.864 m
201.22 567.4 201.654 567.834 202.19 567.834 c
202.726 567.834 203.16 567.4 203.16 566.864 c
203.16 566.328 202.726 565.894 202.19 565.894 c
201.654 565.894 201.22 566.328 201.22 566.864 c
b
201.058 573.654 m
201.058 574.189 201.493 574.624 202.028 574.624 c
202.564 574.624 202.998 574.189 202.998 573.654 c
202.998 573.118 202.564 572.684 202.028 572.684 c
201.493 572.684 201.058 573.118 201.058 573.654 c
b
198.148 574.947 m
198.148 575.483 198.583 575.917 199.118 575.917 c
199.654 575.917 200.088 575.483 200.088 574.947 c
200.088 574.411 199.654 573.977 199.118 573.977 c
198.583 573.977 198.148 574.411 198.148 574.947 c
b
145.93 567.834 m
145.93 568.369 146.364 568.804 146.9 568.804 c
147.436 568.804 147.87 568.369 147.87 567.834 c
147.87 567.298 147.436 566.864 146.9 566.864 c
146.364 566.864 145.93 567.298 145.93 567.834 c
b
201.382 545.201 m
201.382 545.736 201.816 546.17 202.352 546.17 c
202.887 546.17 203.322 545.736 203.322 545.201 c
203.322 544.665 202.887 544.23 202.352 544.23 c
201.816 544.23 201.382 544.665 201.382 545.201 c
b
198.148 541.482 m
198.148 542.018 198.583 542.452 199.118 542.452 c
199.654 542.452 200.088 542.018 200.088 541.482 c
200.088 540.947 199.654 540.512 199.118 540.512 c
198.583 540.512 198.148 540.947 198.148 541.482 c
b
201.22 541.482 m
201.22 542.018 201.654 542.452 202.19 542.452 c
202.726 542.452 203.16 542.018 203.16 541.482 c
203.16 540.947 202.726 540.512 202.19 540.512 c
201.654 540.512 201.22 540.947 201.22 541.482 c
b
201.22 537.602 m
201.22 538.138 201.654 538.572 202.19 538.572 c
202.726 538.572 203.16 538.138 203.16 537.602 c
203.16 537.067 202.726 536.632 202.19 536.632 c
201.654 536.632 201.22 537.067 201.22 537.602 c
b
201.058 533.237 m
201.058 533.773 201.493 534.207 202.028 534.207 c
202.564 534.207 202.998 533.773 202.998 533.237 c
202.998 532.702 202.564 532.267 202.028 532.267 c
201.493 532.267 201.058 532.702 201.058 533.237 c
b
146.092 528.387 m
146.092 528.923 146.526 529.357 147.062 529.357 c
147.597 529.357 148.032 528.923 148.032 528.387 c
148.032 527.852 147.597 527.417 147.062 527.417 c
146.526 527.417 146.092 527.852 146.092 528.387 c
b
161.773 503.009 m
161.773 503.545 162.208 503.979 162.743 503.979 c
163.279 503.979 163.713 503.545 163.713 503.009 c
163.713 502.473 163.279 502.039 162.743 502.039 c
162.208 502.039 161.773 502.473 161.773 503.009 c
b
158.863 503.119 m
158.863 503.655 159.298 504.089 159.833 504.089 c
160.369 504.089 160.803 503.655 160.803 503.119 c
160.803 502.583 160.369 502.149 159.833 502.149 c
159.298 502.149 158.863 502.583 158.863 503.119 c
b
155.792 503.091 m
155.792 503.627 156.226 504.061 156.762 504.061 c
157.297 504.061 157.732 503.627 157.732 503.091 c
157.732 502.556 157.297 502.121 156.762 502.121 c
156.226 502.121 155.792 502.556 155.792 503.091 c
b
152.558 503.094 m
152.558 503.63 152.993 504.064 153.528 504.064 c
154.064 504.064 154.498 503.63 154.498 503.094 c
154.498 502.559 154.064 502.124 153.528 502.124 c
152.993 502.124 152.558 502.559 152.558 503.094 c
b
149.487 503.067 m
149.487 503.602 149.921 504.037 150.457 504.037 c
150.992 504.037 151.427 503.602 151.427 503.067 c
151.427 502.531 150.992 502.097 150.457 502.097 c
149.921 502.097 149.487 502.531 149.487 503.067 c
b
146.229 503.094 m
146.229 503.63 146.663 504.064 147.199 504.064 c
147.735 504.064 148.169 503.63 148.169 503.094 c
148.169 502.559 147.735 502.124 147.199 502.124 c
146.663 502.124 146.229 502.559 146.229 503.094 c
b
143.182 503.094 m
143.182 503.63 143.616 504.064 144.152 504.064 c
144.687 504.064 145.122 503.63 145.122 503.094 c
145.122 502.559 144.687 502.124 144.152 502.124 c
143.616 502.124 143.182 502.559 143.182 503.094 c
b
139.948 503.043 m
139.948 503.578 140.383 504.012 140.918 504.012 c
141.454 504.012 141.888 503.578 141.888 503.043 c
141.888 502.507 141.454 502.072 140.918 502.072 c
140.383 502.072 139.948 502.507 139.948 503.043 c
b
136.877 503.067 m
136.877 503.602 137.311 504.037 137.847 504.037 c
138.382 504.037 138.817 503.602 138.817 503.067 c
138.817 502.531 138.382 502.097 137.847 502.097 c
137.311 502.097 136.877 502.531 136.877 503.067 c
b
133.967 503.006 m
133.967 503.542 134.401 503.976 134.937 503.976 c
135.472 503.976 135.907 503.542 135.907 503.006 c
135.907 502.47 135.472 502.036 134.937 502.036 c
134.401 502.036 133.967 502.47 133.967 503.006 c
b
130.733 503.009 m
130.733 503.545 131.168 503.979 131.703 503.979 c
132.239 503.979 132.673 503.545 132.673 503.009 c
132.673 502.473 132.239 502.039 131.703 502.039 c
131.168 502.039 130.733 502.473 130.733 503.009 c
b
184.326 543.605 m
220.458 543.605 l
S
201.301 502.683 m
201.301 503.218 201.735 503.653 202.271 503.653 c
202.806 503.653 203.241 503.218 203.241 502.683 c
203.241 502.147 202.806 501.712 202.271 501.712 c
201.735 501.712 201.301 502.147 201.301 502.683 c
b
255.863 519.9 m
255.863 520.436 256.297 520.87 256.833 520.87 c
257.369 520.87 257.803 520.436 257.803 519.9 c
257.803 519.364 257.369 518.93 256.833 518.93 c
256.297 518.93 255.863 519.364 255.863 519.9 c
b
259.258 523.052 m
259.258 523.588 259.692 524.022 260.228 524.022 c
260.764 524.022 261.198 523.588 261.198 523.052 c
261.198 522.517 260.764 522.083 260.228 522.083 c
259.692 522.083 259.258 522.517 259.258 523.052 c
b
255.863 528.872 m
255.863 529.408 256.297 529.842 256.833 529.842 c
257.369 529.842 257.803 529.408 257.803 528.872 c
257.803 528.337 257.369 527.902 256.833 527.902 c
256.297 527.902 255.863 528.337 255.863 528.872 c
b
253.196 530.812 m
253.196 531.348 253.63 531.782 254.166 531.782 c
254.701 531.782 255.136 531.348 255.136 530.812 c
255.136 530.277 254.701 529.842 254.166 529.842 c
253.63 529.842 253.196 530.277 253.196 530.812 c
b
255.863 534.207 m
255.863 534.743 256.297 535.177 256.833 535.177 c
257.369 535.177 257.803 534.743 257.803 534.207 c
257.803 533.672 257.369 533.237 256.833 533.237 c
256.297 533.237 255.863 533.672 255.863 534.207 c
b
259.258 533.965 m
259.258 534.501 259.692 534.935 260.228 534.935 c
260.764 534.935 261.198 534.501 261.198 533.965 c
261.198 533.429 260.764 532.995 260.228 532.995 c
259.692 532.995 259.258 533.429 259.258 533.965 c
b
256.106 541.967 m
256.106 542.503 256.54 542.937 257.076 542.937 c
257.611 542.937 258.046 542.503 258.046 541.967 c
258.046 541.432 257.611 540.997 257.076 540.997 c
256.54 540.997 256.106 541.432 256.106 541.967 c
b
252.711 542.21 m
252.711 542.745 253.145 543.18 253.681 543.18 c
254.216 543.18 254.651 542.745 254.651 542.21 c
254.651 541.674 254.216 541.24 253.681 541.24 c
253.145 541.24 252.711 541.674 252.711 542.21 c
b
255.863 545.362 m
255.863 545.898 256.297 546.332 256.833 546.332 c
257.369 546.332 257.803 545.898 257.803 545.362 c
257.803 544.826 257.369 544.392 256.833 544.392 c
256.297 544.392 255.863 544.826 255.863 545.362 c
b
259.258 548.03 m
259.258 548.565 259.692 549 260.228 549 c
260.764 549 261.198 548.565 261.198 548.03 c
261.198 547.494 260.764 547.06 260.228 547.06 c
259.692 547.06 259.258 547.494 259.258 548.03 c
b
262.411 548.272 m
262.411 548.808 262.845 549.242 263.381 549.242 c
263.916 549.242 264.351 548.808 264.351 548.272 c
264.351 547.736 263.916 547.302 263.381 547.302 c
262.845 547.302 262.411 547.736 262.411 548.272 c
b
256.106 550.94 m
256.106 551.475 256.54 551.91 257.076 551.91 c
257.611 551.91 258.046 551.475 258.046 550.94 c
258.046 550.404 257.611 549.97 257.076 549.97 c
256.54 549.97 256.106 550.404 256.106 550.94 c
b
259.258 552.88 m
259.258 553.415 259.692 553.85 260.228 553.85 c
260.764 553.85 261.198 553.415 261.198 552.88 c
261.198 552.344 260.764 551.91 260.228 551.91 c
259.692 551.91 259.258 552.344 259.258 552.88 c
b
259.016 560.397 m
259.016 560.933 259.45 561.367 259.986 561.367 c
260.521 561.367 260.956 560.933 260.956 560.397 c
260.956 559.861 260.521 559.427 259.986 559.427 c
259.45 559.427 259.016 559.861 259.016 560.397 c
b
262.324 560.077 m
262.324 560.613 262.758 561.047 263.294 561.047 c
263.829 561.047 264.264 560.613 264.264 560.077 c
264.264 559.541 263.829 559.107 263.294 559.107 c
262.758 559.107 262.324 559.541 262.324 560.077 c
b
255.863 563.307 m
255.863 563.843 256.297 564.277 256.833 564.277 c
257.369 564.277 257.803 563.843 257.803 563.307 c
257.803 562.771 257.369 562.337 256.833 562.337 c
256.297 562.337 255.863 562.771 255.863 563.307 c
b
252.953 560.155 m
252.953 560.69 253.387 561.125 253.923 561.125 c
254.459 561.125 254.893 560.69 254.893 560.155 c
254.893 559.619 254.459 559.185 253.923 559.185 c
253.387 559.185 252.953 559.619 252.953 560.155 c
b
255.863 558.457 m
255.863 558.993 256.297 559.427 256.833 559.427 c
257.369 559.427 257.803 558.993 257.803 558.457 c
257.803 557.921 257.369 557.487 256.833 557.487 c
256.297 557.487 255.863 557.921 255.863 558.457 c
b
252.711 550.94 m
252.711 551.475 253.145 551.91 253.681 551.91 c
254.216 551.91 254.651 551.475 254.651 550.94 c
254.651 550.404 254.216 549.97 253.681 549.97 c
253.145 549.97 252.711 550.404 252.711 550.94 c
b
253.141 547.952 m
253.141 548.488 253.575 548.922 254.111 548.922 c
254.646 548.922 255.081 548.488 255.081 547.952 c
255.081 547.416 254.646 546.982 254.111 546.982 c
253.575 546.982 253.141 547.416 253.141 547.952 c
b
249.558 548.515 m
249.558 549.05 249.992 549.485 250.528 549.485 c
251.064 549.485 251.498 549.05 251.498 548.515 c
251.498 547.979 251.064 547.545 250.528 547.545 c
249.992 547.545 249.558 547.979 249.558 548.515 c
b
256.019 568.322 m
256.019 568.858 256.453 569.292 256.989 569.292 c
257.524 569.292 257.959 568.858 257.959 568.322 c
257.959 567.786 257.524 567.352 256.989 567.352 c
256.453 567.352 256.019 567.786 256.019 568.322 c
b
255.776 577.537 m
255.776 578.073 256.21 578.507 256.746 578.507 c
257.282 578.507 257.716 578.073 257.716 577.537 c
257.716 577.001 257.282 576.567 256.746 576.567 c
256.21 576.567 255.776 577.001 255.776 577.537 c
b
252.381 579.962 m
252.381 580.497 252.815 580.932 253.351 580.932 c
253.887 580.932 254.321 580.497 254.321 579.962 c
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trailer
<<
/Size 78
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/Info 77 0 R
/ID [<2f5ac051b5669da24f77eb0d3e1ab8e4><2f5ac051b5669da24f77eb0d3e1ab8e4>]
>>
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212593
%%EOF