摘要
塑料间隔装置中的静电荷已在体外被证明可以减少用于吸入的哮喘药物的输送,但静电荷对体内药物沉积的影响尚不清楚。对10例轻度哮喘患者进行六方随机交叉研究。测试了两个塑料垫片(Nebuhaler和Volumatic)和一个金属垫片(Nebuchamber)。这些间隔物被“启动”或“未启动”。引爆时,将20剂量的安慰剂气溶胶发射到一个新的间隔体中,因此在内部表面涂上表面活性剂,使静电荷最小化。未启动的间隔物是新的,未进行处理。加压气雾剂罐注入布地奈德(200微克普米克)用放射性核素99mTc进行放射性标记,并用伽马闪烁法测量肺沉积。在研究的临床阶段之前,放射性标签被证明是药物物质的有效标记。吸入塑料垫片后,填充显著增加了平均全肺沉积(Nebuhaler填充37.7%,未填充26.7%,p=0.01;容积填充32.0%,未填充22.1%,p=0.02)。 Priming had no effect on the mean whole lung deposition following inhalation from the Nebuchamber (primed 33.5% and unprimed 32.9%). Lung deposition in vivo from plastic spacer devices will vary according to the electrostatic charge on the spacer walls. Priming reduces retention of drug on plastic spacer devices and increases lung deposition. Metal spacers are not susceptible to static charge, which should result in more predictable lung deposition.