TY -的T1 -静电隔离设备对糖皮质激素的影响气溶胶沉积在哮喘病人JF -欧洲呼吸杂志》乔和J SP - 606 LP - 610欧元六世- 11 - 3盟肯扬CJ盟——Thorsson L AU -纽曼,L AU -•伯格斯特罗姆SP Y1 - 1998/03/01 UR - //www.qdcxjkg.com/content/11/3/606.abstract N2 -塑料隔离器中的静电电荷已在体外被证明可以减少用于吸入的哮喘药物的输送，但静电电荷对体内药物沉积的影响尚不清楚。对10例轻度哮喘患者进行六方随机交叉研究。测试了两个塑料垫片(Nebuhaler和Volumatic)和一个金属垫片(Nebuchamber)。间隔物要么被“启动”，要么被“未启动”。启动的方法是将20剂量的安慰剂气雾剂射入一个新的间隔层中，从而在内部表面涂上表面活性剂，将静电荷降至最低。未启动的间隔物是新的，没有处理过。加压气雾剂罐给予布地奈德(200微克普米克)放射标记放射性核素99mTc和肺沉积测量伽玛闪烁。在研究的临床阶段之前，放射标记被证明是药物的有效标记。吸入塑料垫片后，吸入底泥显著增加了平均全肺沉积(雾化吸入底泥37.7%和未吸入底泥26.7%，p=0.01; Volumatic primed 32.0% and unprimed 22.1%, p=0.02). Priming had no effect on the mean whole lung deposition following inhalation from the Nebuchamber (primed 33.5% and unprimed 32.9%). Lung deposition in vivo from plastic spacer devices will vary according to the electrostatic charge on the spacer walls. Priming reduces retention of drug on plastic spacer devices and increases lung deposition. Metal spacers are not susceptible to static charge, which should result in more predictable lung deposition. ER -