抽象的
两组骨髓移植(BMT)与需要重症监护病房(ICU)入场,在骨髓移植的早期阶段,发热非心源性呼吸衰竭的收件人进行了比较:那些谁证实的感染性肺炎和那些在人支气管肺泡灌洗(BAL)未能建立诊断。参加了38个连续的中性细胞型BMT受访者,入口具有发热的非诊断呼吸衰竭的ICU。所有这些都经过有病毒,真菌,细菌和组织病理学检查的BAL。肺活组织检查在非诊断患者中进行,以便与BAL结果进行比较。评估了血液学,生物,呼吸衰竭等器官衰竭参数,传染病结果,结果和肺活检结果。BAL允许在16家BMT接受者中建立传染性诊断。22名患者未经验证。如果没有在上ICU入院呼吸衰竭参数的显著差异,非侵入性连续气道正压通气,将其提供给11名患者每个组中,是显著更成功的患者证实的感染性肺炎(11对比0 11患者6)和使能肿瘤插管能够在显着更多的传染病患者中避免(第22名患者中的16例,共有22例)。 The evolution of patients without diagnosis was significantly different with more frequent renal failure, hepatic failure, and death (20 of 22 versus 9 of 16 patients). Post mortem biopsies confirmed the absence of micro-organisms, but endothelial damage and fibrosis was found in 14 of the 22 patients. In conclusion, in the early phase of bone marrow transplantation the recipients without proven aetiology of pneumonia have a worse outcome than grafted patients with proven infectious pneumonia.