Extract
Human disease genomics holds huge promise for informing the development of novel therapeutics and targeting of therapies to the right patients (precision medicine). However, the one-size-fits-all approach of many genome-wide association studies (GWAS), using case definitions based on broad clinical categories and ignoring interactions with demographic and environmental factors, will not be good enough to realise the full potential of this methodology.
Abstract
Subtype- and sex-specific genome-wide association and interaction studies have the potential to deliver novel mechanistic understanding of asthma and inform precision medicinehttp://bit.ly/3UBr0pS
Footnotes
Conflict of interest: K.A. Fawcett has nothing to disclose.
Support statement: This work was supported by Asthma and Lung UK (grant AUK-CDA-2019–414). Funding information for this article has been deposited with theCrossref Funder Registry.
- ReceivedOctober 4, 2022.
- AcceptedNovember 2, 2022.
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