Abstract
Background:快速发展的Covid-19大流行对世界各地的重大诊断挑战构成了。理解SARZ-COV-2 RT-PCR的敏感性/特异性有助于解决与Covid-19录取有关的临床挑战。
目标:确定RT-PCR阳性和负数成年医院Covid-19录取的相对比例,并确定它们之间存在显着差异。
Methods:In this retrospective cohort study we examined the demographics, clinical and biochemical characteristics of COVID-19 adult admissions to Barnet Hospital in the first month of the disease outbreak in the UK. SARS-CoV-2 RT-PCR-negative patients were diagnosed if alternative diagnosis was unlikely and 3 of 4 of the following were present:
-classical symptoms (new persistent cough)
-发烧/ tachypnea /缺氧
-lymphopaenia
-CXR changes
主要终点是死亡at 30 days from initial presentation.
Results:572 patients were admitted with COVID-19, of whom 450 were RT-PCR positive (79%) and 122 were RT-PCR negative (21%). infection at Barnet Hospital in the first month.
There was no significant difference in most of the studied parameters between the PCR-positive and PCR-negative COVID-19 patients. The only exception was the neutrophil count, which was found to be higher in the PCR-negative cohort (p<0.001).
结论:Our study confirms that clinical criteria are effective in diagnosing COVID-19 in the presence of negative RT-PCR and has demonstrated no significant clinical differences between RT-PCR-positive and RT-PCR-negative COVID-19 admissions.
脚注
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 5112.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available atwww.ers-education.org.(ERS member access only).
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