摘要
嗜酸性气道炎症存在于许多伴有哮喘呼吸症状但肺功能正常的患者中。研究了36例连续出现这些特征的患者。25名哮喘患者和43名健康志愿者作为对照组。观察血液和诱导痰中嗜酸性炎症的征象。有呼吸系统症状的患者接受吸入二丙酸倍氯米松(BDP)单盲治疗,每日800微克,或安慰剂治疗3个月,并在3个月和1年后复查。哮喘组嗜酸性炎症程度明显低于哮喘组(p<0.01)。BDP治疗3个月可显著降低总症状评分(p<0.001)、咳嗽评分(p<0.0001)、血嗜酸性粒细胞数(p<0.01)。单纯咳嗽组与安慰剂组相比有显著性改善(p<0.05)。随访1年,17例(55%)仍有症状,但肺功能正常。4名(13%)患者出现哮喘,另外10名(32%)患者无症状。 Using lung function measurements and induced sputum analyses, a group of patients with symptoms suggestive of asthma and signs of eosinophilic airway inflammation but without enough airflow variability to be diagnosed as asthmatics were detected. They seemed to respond favourably to inhaled beclomethasone dipropionate treatment.