摘要
镁(Mg)缺乏与气道高反应性、喘息和肺功能损害有关。低镁血症的患病率及其对哮喘的影响尚不清楚。因此,本前瞻性研究旨在评估低血清Mg水平的患病率,以确定低镁血症(血清Mg水平<0.74 mmol x L(-1))是否与慢性稳定哮喘患者的哮喘严重程度和住院次数增加有关。93名慢性稳定型哮喘患者在哮喘诊所接受定期随访。到哮喘诊所时,对每个受试者进行面谈和临床评估。测定血清Mg水平(正常0.74 ~ 1.2 mmol × L(-1))及哮喘的严重程度。记录用药情况。在测量血清Mg水平之前的最后三个月,对因哮喘加重而住院的总人数进行评分。25例(27%)患者Mg水平较低,平均+/-SD为0.69+/-0.04 mmol x L(-1), 68/93例(73%)患者Mg水平正常(0.82+/-0.08 mmol x L(-1))。Mg水平低的哮喘患者住院人数为10/25(40%),而Mg水平正常的哮喘患者住院人数为8/68 (12%)(p<0.01)。 Multiple logistic regression analysis showed that severe asthma was the only factor associated significantly with hypomagnesaemia (p=0.04). No effect was observed for inhaled beta-agonist, inhaled steroid or theophylline therapy on serum Mg level. To conclude, hypomagnesaemia is common in chronic asthmatics. Chronic asthmatics with low Mg tend to have more hospitalizations than chronic asthmatics with normal Mg. Hypomagnesaemia was also associated with more severe asthma.