抽象的
本研究的目的是研究特定支气管反应性和各自特异性支气管和免疫反应之间的关系。二十一名患者用乳糖和面粉接受支气管挑战。颗粒气溶胶由计算机控制的空气溶剂产生。特定的支气管攻击结果表达为面粉(PDF)的挑衅剂量,在一秒(FEV1)中导致强制呼气量的20%或15%降低。对于每个受试者,与面粉攻击期间观察到的FEV1减少与乳糖攻击的99.7%置信区间的计算下限进行了比较。受试者还经历了对甲素的非特异性挑战和对小麦的特定免疫球蛋白E的测量。吸入乳糖没有显着影响FEV1。九个受试者对小麦粉具有高反应性,具有PDF20 <400 microg。五个受试者具有中间反应性:FEV1下降<20%,但在用乳糖试验中的比例显着大。对于7个受试者,FEVI在1390微歌中吸入剂量的FEVI没有显着变化。 The results for specific bronchial challenge were significantly correlated with those for the methacholine test (p<0.02). Positive skin tests and specific immunoglobulin E against wheat were observed more frequently in the high reactivity group. Specific bronchial challenge can be performed safely to establish precise dose-response curves. The provocative dose of flour causing a 20% decrease in forced expiratory volume in one second is useful for evaluating the degree of specific reactivity but is not suitable in cases of intermediate reactivity in which comparison with the lactose test is necessary. Specific reactivity is probably a function of immunological and nonspecific bronchial reactivities.