抽象的
关于严重慢性阻塞性肺病(COPD)的患者对不同类型的运动训练的生理反应提供有限的信息。本研究的目的是两倍:首先,调查严重COPD患者达到达到峰值载荷的60%训练的生理反应;其次,为了研究这些患者的间隔(i)与连续(c)培训的影响。二十一名COPD患者(平均+/- SD强制呼气量一秒:37 +/- 15%的预测,ressoxim在休息时)在基线和8周后训练后评估。患者随机分配给I或C培训。每天5天,每天30分钟进行训练,每周5天。两种培训计划的总工作负荷都是相同的。C培训导致氧气消耗(V'O2)的显着增加(17%,P <0.05)和微小通风(V'e)/ V'O2(P <0.01)和V'e /二氧化碳的降低生产(V'CO2)(P <0.05)以峰值运动能力,而在间隔训练后未观察到这些措施的变化。在次颌骨时,在乳酸产生中观察到显着的减少,在C培训的组中最明显(-31%,P <0.01对-20%,P <0.05)。 Only in the I-trained group did a significant increase in peak work load (17%, p<0.05) and a decrease in leg pain (p<0.05) occur. Training did not result in a significant improvement in lung function, but maximal inspiratory mouth pressure increased in both groups by 10% (C: p<0.05) and 23% (I: p<0.01). The present study shows a different physiological response pattern to interval or continuous training in chronic obstruction pulmonary disease, which might be a reflection of specific training effects in either oxidative or glycolytic muscle metabolic pathways. Further work is required to determine the role of the different exercise programmes and the particular category of patients for whom this might be beneficial.