文摘
我们研究了空气污染对住院的短期影响慢性阻塞性肺疾病(COPD)在欧洲。作为欧洲计划的一部分(空气污染和健康,欧洲的方法(APHEA)),我们分析数据的城市阿姆斯特丹、巴塞罗那、伦敦、米兰、巴黎和鹿特丹资格数据使用一个标准化的方法和统计分析。相对风险使用泊松回归,获得了慢性阻塞性肺病日常招生控制:季节性和其他周期;流感流行;星期;温度;湿度和自相关。总结了各污染物影响估计的意思是每个城市的回归系数加权方差的倒数,允许额外的城市间方差,作为必要的。对于所有年龄段,相对风险(95%置信区间(CL) 95%)为50 microg x m(3)增加每日平均水平的污染物(滞后1 - 3天)(95% CL):二氧化硫1.02 (0.98,1.06);黑烟1.04 (1.01,1.06); total suspended particulates 1.02 (1.00, 1.05), nitrogen dioxide 1.02 (1.00, 1.05) and ozone (8 h) 1.04 (1.02, 1.07). The results confirm that air pollution is associated with daily admissions for chronic obstructive pulmonary disease in European cities with widely varying climates. The results for particles and ozone are broadly consistent with those from North America, though the coefficients for particles are substantially smaller. Overall, the evidence points to a causal relationship but the mechanisms of action, exposure response relationships and pollutant interactions remain unclear.