文摘
最近的研究结果表明,女性可能比男性更容易受吸烟的有害影响在发展中慢性阻塞性肺病(COPD)。本文研究性别和吸烟的互动发展的COPD的肺功能评估和住院。共有13897名受试者中,1920年以后出生,从两个人口研究,9083年从哥本哈根城市心脏研究从斯特鲁普人口研究患有先天中枢性换气()和4814 (GPS), 7 - 16年的随访。数据与信息引起的住院慢性阻塞性肺病。基于横截面数据,CCHS多余的损失估计在一秒钟用力呼气量(FEV1)每pack-year吸烟女性吸烟者吸入和7.4毫升6.3毫升男性吸烟者吸入。全球定位系统(GPS),相应的超额损失残在女性和男性10.5和8.4毫升,分别。二百一十八例CCHS和23个GPS住院随访中。风险久的女性高于男性(相对风险(RRs) 1 - 20、20 - 40和> 40久的7.0(3.5 - -14.1),9.8(4.9 - -19.6)和23.3(10.7 - -50.9)的女性,和3.2(1.1 - -9.1),5.7(2.2 - -14.3)和8.4(3.3 - -21.6)在男性),但交互项性别x久没有达到意义(p = 0.08)。在GPS结果相似。调整后更详细地抽烟,女性在两个组别的风险增加住院的慢性阻塞性肺病的男性相比,RR CCHS 1.5(1.2 - -2.1)和3.6(1.4 - -9.0)的GPS。 This was not likely to be caused by a generally increased rate of hospital admission for females. Results were similar when including deaths from COPD as endpoint. In two independent population samples, smoking had greater impact on the lung function of females than males, and after adjusting for smoking females subsequently suffered a higher risk of being admitted to hospital for COPD. Results suggest that adverse effects of smoking on lung function may be greater in females than in males.