Objective Why some people recover emotionally after diagnosis and treatment of cancer
and others do not is poorly understood. To identify factors around the time of diagnosis that …

There is a paucity of evidence surrounding the optimal antifungal therapy for use in chronic
pulmonary aspergillosis (CPA) and the duration of therapy remains unclear. We …

Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as
primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose …

Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million people worldwide
making it an under recognised, but significant health problem across the globe, conferring …

The field of fungal respiratory infection continues to evolve and develop, with many recent
key advances. Patients, and possibly colonized patients, with Pneumocystis require isolation …

Intracellular occupancy of the respiratory epithelium is a useful pathogenic strategy facilitating
microbial replication and evasion of professional phagocytes or circulating antimicrobial …

Chronic pulmonary aspergillosis (CPA) is often poorly responsive to antifungal treatment;
secondary infections increase morbidity/mortality, particularly in progressive cases. Interferon …

Background The sensitivity of patient-reported outcomes (PROs) to detect the effects of
treatment change depends on the match between the change in items of the PRO and the …

Objective: The F508del mutation occurs in approximately 3.5% of Caucasian population of
Northern Europe. Heterozygotes have increased risk for asthma and reduced pulmonary …

The Severe Asthma Questionnaire (SAQ) is sensitive to change and clinically significant
improvement was detected within 4 weeks of starting biologic therapy. The MCID of the SAQ …