Extract
We thank D. Jaffuel and co-workers for their interest in our randomised controlled clinical trial (RCT) demonstrating the absence of reduction in muscle sympathetic nerve activity (MSNA) despite reduction of respiratory events during sleep when using adaptive servo-ventilation (ASV) in patients suffering from chronic systolic heart failure with reduced left ventricular ejection fraction (HFrEF) and central sleep apnoea (CSA) [1]. This work was a substudy of the SERVE-HF trial, the largest RCT conducted to date in patients with both CSA and HFrEF [2].
Abstract
The interaction between sleep disordered breathing and heart failure pathophysiology remains to be fully elucidated, as does the real-life impact of sleep disordered breathing management in large cohorts of heart failure patients https://bit.ly/3ItHv3t
Footnotes
Conflict of interest: R. Tamisier reports receiving lecture fees from ResMed, and grant support through his institution from ResMed, Agiradom and Philips, and travel grants form Agiradom. J-L. Pépin reports grant support through his institution from ResMed, Agiradom Vitalaire and Philips, and lecture fees and travel grants form RESMED, Philips and Agiradom. P. Lévy reports no conflict of interest.
Support statement: This work was supported by the endowment fund “Agir pour les maladies chroniques”, and the French National Research Agency (ANR) in the framework of the “Investissements d'avenir” programme (ANR-15-IDEX-02). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received February 11, 2023.
- Accepted February 13, 2023.
- Copyright ©The authors 2023. For reproduction rights and permissions contact permissions{at}ersnet.org