Extract
Lung cancer biology has changed, with a histological shift from the previously dominant central squamous cell carcinoma to peripheral lung adenocarcinomas. Changes in cigarette characteristics and smoking practice are commonly attributed; however, other carcinogens such as air pollution and diesel fumes may also play an as yet unidentified role in lung cancers in never-smokers [1]. This shift and advances in cross sectional imaging have resulted in increasing adoption of low dose computed tomography (CT)-based lung cancer screening, when earlier attempts with chest radiography and sputum cytology failed [2].
Abstract
Autofluorescence bronchoscopy can detect proximal preneoplastic lesions. Intensive surveillance with this modality, however, may not alter health outcomes. https://bit.ly/3s98vN1
Footnotes
Conflict of interest: K.M. Fong reports grants from MRFF EPCDR (Improving Diagnosis in Cancers Low Survival Rates), NHMRC (Ideas grant: Early lung cancer biomarkers), MRFF Next Generation Clinical Researchers Program (Practitioner Fellowship), NHMRC Project (Novel biomarkers for lung cancer), NHMRC (low dose computed tomography to diagnose lung cancer); royalties from UpToDate and Cochrane Clinical Answers; unpaid leadership role at Asia Pacific Society of Respirology (former President); support with a loan bronchoscope for 12 months for the purpose of a research trial study (no financial funding) from Olympus; software licensing for computer aided diagnosis research in the International Lung Screen Trial (ILST) from Mevis Veolity; outside the submitted work. G.N. Olive and R.V. Bowman report receipt of loan bronchoscopes from Olympus Australia; outside the submitted work. H. Marshall reports grants from NHMRC and MRFF; lecture honoraria from AstraZeneca and Boehringer Ingelheim; travel and accommodation expenses from Boehringer Ingelheim; special interest group convenor (tobacco control) for Thoracic Society ANZ (unpaid); expert advisory member (lung cancer advocacy) for Lung Foundation Australia (unpaid); education committee member for Asian Pacific Society of Respirology (unpaid); outside the submitted work. I.A. Yang has nothing to disclose.
Support statement: This work was supported by NHMRC, MRFF and TPCH Foundation.
- Received April 20, 2022.
- Accepted April 27, 2022.
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