Extract
Pulmonary hypertension (PH) is a frequent complication of chronic obstructive pulmonary disease (COPD) with poor prognosis, especially in its severe form [1]. Accordingly, current guidelines distinguish patients with severe PH from those with moderate PH [2]. Patients with COPD and severe PH often present with worse hypoxaemia than those with moderate PH, despite having milder airflow obstruction [3–5]. The mechanisms underlying severe hypoxaemia in these patients have not been elucidated. This study aimed to analyse the determinants of hypoxaemia in severe PH associated with COPD by assessing ventilation-perfusion (VA/Q) relationships with the multiple inert gas elimination technique (MIGET).
Footnotes
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Conflict of interest: Lucilla Piccari has received research funding from and served as a speaker for Janssen-Cilag and Ferrer International, participated in advisory boards for Janssen-Cilag, Ferrer International and United Therapeuthics as well as received support for attending congresses from Janssen-Cilag, Merck Sharp & Dome and Ferrer International, all of which not related to this manuscript.
Conflict of interest: Isabel Blanco reports lecture honoraria from Janssen, MSD and Ferrer; outside the submitted work. Yolanda Torralba reports lecture honoraria from TEVA; outside the submitted work.
Conflict of interest: Felip Burgos reports consulting fees from Scientific Advisory Board Medical Graphics Diagnostics, outside the submitted work.
Conflict of interest: Roberto Rodríguez-Roisín reports grants from CHIESI Spain, outside the submitted work.
Conflict of interest: Joan Albert Barberà reports consulting fees from Merck Sharp & Dome, Janssen-Cilag, Acceleron Pharma; lecture honoraria from Ferrer International, Janssen-Cilag, Merck Sharp & Dome; travel support from Merck Sharp & Dome, Janssen-Cilag; outside the submitted work. All other authors have nothing to disclose.
- Received March 3, 2022.
- Accepted May 12, 2023.
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