抽象的
二氧化氮(NO2)是许多氮化合物之一,含有燃烧的副产物,并且在使用气体或其他燃料以进行加热和烹饪后发生在国内环境中。在这项研究中,我们研究了哮喘成年人和儿童症状,肺功力和气道高反应(AHR)对症状,肺功能和气道高响应性(AHR)的影响。此外,在相同的主题中,我们检查了与气体空间加热器中燃烧副产品混合的相同水平的效果。受试者是九名成人,19-65岁,11例儿童,7-15岁,患有诊断的哮喘,严重足以要求每日药物治疗。所有受试者均具有明显的AHR至组胺。曝光在五个单独的场合,分开1周,至:1)环境空气,从建筑物外抽出;2)环境空气中每百万(PPM)NO2 0.3份;3)环境空气中0.6ppm no2;4)环境空气+燃烧副产品+ NO2,总共0.3 ppm;5)环境空气+燃烧副产品+ NO2,总共0.6ppm。 Effects were measured as changes in lung function and symptoms during and 1 h after exposure, in AHR 1 h and 1 week after exposure, and in lung function and symptoms during the week following exposure. Exposure to NO2 either in ambient air or mixed with combustion by-products from a gas heater, had no significant effect on symptoms or lung function in adults or in children. There was a small, but statistically significant, increase in AHR after exposure to 0.6 ppm NO2 in ambient air. However, there was no effect of 0.6 ppm NO2 on AHR when the combustion by-products were included in the test atmosphere nor of 0.3 ppm NO2 under either exposure condition. We conclude that a 1 h exposure to 0.3 or 0.6 ppm NO2 has no clinically important effect on the airways of asthmatic adults or children, but that 0.6 ppm may cause a slight increase in airway hyperresponsiveness.