抽象
假设假设致命大豆哮喘的特征临床进程可以反映特异性免疫病理学发现。与新西兰的25例致命哮喘病例进行比较来自巴塞罗那的致命大豆粉末哮喘患者。使用标准链霉抗生物素蛋白 - 生物素过氧化物酶技术通过单克隆抗体染色肺组织的切片。确定以下细胞类型:肥大细胞,“活化”嗜酸性粒细胞,中性粒细胞,单核细胞/巨噬细胞,CD3 + T细胞和CD8 + T细胞。在上皮细胞和粘膜下计数阳性染色细胞分别为每毫米和mm2表示的数量。将气道分为较大(内部周长(PI)> 2mm)和更小(PI <2mm)。首先,所有气道都在一起进行了研究;随后,分别研究了较大和较小的气道。两组间肥大细胞,嗜酸性粒细胞,中性粒细胞和单核细胞/巨噬细胞的数量的差异并不显着。当所有气道一起携带时,在致命大豆哮喘中,CD3 +和CD8 + T细胞的数量显着降低。 In larger airways, the difference was not significant in the epithelium, but was significant in the submucosa for CD3+ cells. CD8+ cells were significantly reduced in fatal soybean asthma both in the epithelium and the submucosa. The cell counts in smaller airways were not significantly different either in the epithelium or in the submucosa for CD3+ cells. The numbers of CD8+ cells were not different in the epithelium, but were significantly reduced in the submucosa of fatal soybean asthma cases. We conclude that the numbers of CD3+ and CD8+ T-cells are substantially reduced in fatal soybean asthma. These data together with the clinical features of the fatal attack suggest a different mechanism(s) from that described for most asthma deaths, probably involving anaphylaxis.