抽象
气道炎症在儿童哮喘发病机制中的作用是不确定的。在目前的研究中,在前12个月内患有>或= 5次喘息症和哮喘症状(EIA)的27岁的特应性和非植物儿童,在单独的日子中进行了甲素攻击和运动试验按月间隔。受试者在研究前12个月内未接受口服或吸入皮质类固醇。吸入甲素的剂量 - 反应关系表达为累积剂量在一秒钟(PD20)中强制呼气量降低20%。在运动试验之前测量一秒钟(FEV1)和峰值呼气流量(PEF)的强制呼气量,在最大锻炼后在0,3,5,10,15和20分钟之前测量。在第一次甲胆碱攻击和运动试验之后,儿童以双盲方式随机化,以接收吸入的替代塞仑二倍体(BDP)200微克B.I.D。或安慰剂B.I.D.从Diskhaler到3个月。在测试时,所有孩子都在无症状,在整个研究期间挑战之前,任何受试者的基线FEV1都没有显着变化。 When compared to placebo, the bronchial responsiveness to exercise and methacholine was significantly attenuated in the children who had received inhaled BDP for at least 1 month. There was no relationship between the bronchial responsiveness to methacholine and exercise. There was no significant difference in the bronchial responsiveness to either stimulus in the atopic and nonatopic children. The results of this study suggest that immunoglobulin E (IgE)- and non-IgE-mediated airway inflammation are important in exercise- and methacholine-induced bronchoconstriction in children with recurrent wheeze, although it is probable that different mechanisms are responsible.