抽象
生活质量的措施越来越多地用作药物用于治疗哮喘的研究重要疗效终点。这项研究的目的是评估双方的敏感性改变和四种不同生活质量的仪器的哮喘患者的构想效度。在一项双盲,平行组研究,120名中度哮喘患者,年龄18-70岁之间,分别接受吸入的沙美特罗50微克b.i.d.的或吸入沙丁胺醇400微克每日两次除了呼吸情况,生活质量在6周后测定后续使用:1)寿命问卷(AQLQ)的哮喘质量;2)生活哮喘问卷(LWAQ);3)疾病影响资料(SIP);4)评定量表(RS);和标准甘布尔(SG)实用程序。沙美特罗导致几乎所有的临床结果在沙丁胺醇显著的改善。 Although all the quality of life instruments showed the same trend in favour of salmeterol, only the AQLQ and RS utilities showed significantly greater improvement on salmeterol than on salbutamol. Except for the AQLQ, the correlation between change in lung function and change in quality of life was generally low. Whereas, the AQLQ correlated well with the patient's overall assessment of efficacy (r = 0.64), the LWAQ, SIP and utilities failed to show such a correlation. The AQLQ showed the best correlation with symptom scores. The cross-sectional correlation between the AQLQ and the LWAQ was 0.73, whereas the longitudinal correlation was only 0.29. The SG generally showed poor correlation with other measures, including the RS. In conclusion, patients given salmeterol showed a greater improvement in quality of life compared to patients given salbutamol. Of the disease-specific questionnaires the Asthma Quality of Life Questionnaire was found to be more responsive to change than the Living With Asthma Questionnaire and showed greater validity. Of the generic instruments, the rating scale utilities were most responsive. The Standard Gamble showed poor correlation with other measures.