Abstract
Background:据报道,与2型高(T2-高)哮喘相比,2型低(T2-低)哮喘对治疗的反应较少,但是驱动T2---------------------但对驱动T2-低哮喘的机制知之甚少。甘露醇测试是一种间接的支气管前体测试,反映了与嗜酸性气道炎症和肥大细胞激活相关的气道高反应性(AHR)。
Aim:To compare changes in AHR to mannitol in patients with T2-low versus T2-high asthma after 12 months management in a specialist setting.
Methods:Patients with asthma referred to a specialist outpatient clinic at a Danish university hospital were enrolled consecutively. FeNO, asthma control (ACQ), AHR to mannitol and induced sputum were assessed at baseline and after 12 months. T2-low asthma was defined as a FeNO < 25 ppb and sputum eosinophils < 3% at inclusion. AHR was defined as a 15% fall in FEV1 (PD15). A PD15 of 635 mg was assigned for a negative follow-up test.
结果:Thirty patients with asthma (Females: 53%, age: 29 years (15-59)) and a positive mannitol test were followed. Eleven (37%) had T2-high and 19 (63%) had T2-low asthma. Both groups improved in AHR: PD15 improvement: 346 (95% CI: 217-476, p<0.001) and 221 (95% CI: 117-325, p<0.001) and in ACQ: improvement: 0.35 (95% CI: -0.35-1.03, P=0.29) and 0.38 (95% CI: 0.06-0.70, P=0.02) for T2-high and low respectively. No differences between groups were detected: PD15: 125 (95% CI: -36-287, P=0.12) and ACQ: -0.03 (95% CI: -0.66-0.60, P=0.91).
Conclusion:Patients with T2-high and T2-low asthma experience similar improvements in AHR to mannitol and ACQ after 12 months of specialist management. Mechanisms driving AHR in T2-low asthma need to be further elucidated.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4249.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available atwww.ers-education.org(ERS member access only).
- Copyright ©the authors 2019