摘要
建议避免过敏原或减少过敏原措施对过敏性哮喘患者的治疗具有重要意义。本研究的目的是测试新近开发的空气净化器捕捉空气过敏原颗粒的能力,并改善对空气过敏原敏感的哮喘患者的临床参数。对45例过敏性哮喘患者进行为期6个月的双盲研究。患者被分为三组,每组15例。第一组为在客厅和卧室使用有源空气净化器。在第2组中,使用安慰剂空气清洁剂和不渗透过敏原的床垫套。在组3中,执行相同的干预组2,但使用活跃的空气净化器。在干预前、3个月和6个月后测量床垫和地板灰尘中的过敏原水平。6个月后,拆卸空气净化器,并分析过滤器收集的灰尘量和过敏原含量。分别于干预前、干预后3、6个月测定免疫及肺功能参数。 Considerable amounts of airborne dust and allergenic particles were captured in the filters of the air-cleaners. Up to the 18.9 g of dust, 4,513 ng of house dust mite allergen, Der p 1, and 50,000 mU of cat allergen, Fel d 1, (in houses with cats) were collected by air-cleaners in living-rooms. Only in Group 3 (in which both active air-cleaners and mattress covers were used) was a small (less than 1 doubling dose) but statistically significant improvement of provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second (PC20) observed (from 5.96 to 9.02 mg x mL(-1)). The amount of dust and house dust mite allergen collected in the filters was significantly correlated with an improvement of peak flow variation. In combination with other allergen avoidance measures, the examined air-cleaners can contribute to diminished allergen exposure and improvement of airway hyperresponsiveness in asthmatic patients.