摘要

目的:研究组织特异性转录因子-1 (tissue specific transcription factor-1, TTF-1)在小细胞肺癌(small cell lung carcinoma, SCLC)细胞学标本中的免疫细胞化学表达，探讨其在肺癌细胞学诊断中的价值。方法:每个病例的诊断都是在细胞学标本上作出的，并在随后的支气管活检标本上证实。TTF-1用兔抗血清免疫细胞化学方法检测。检测了41例SCLC和17例非小细胞癌中TTF-1的表达情况。后者又细分为腺癌8例和鳞状细胞癌9例。结果:41例SCLC中38例(92.7%)，8例腺癌中5例(62.5%)，9例SCC中1例(11%)对TTF-1的核免疫反应阳性。在SCLC和NSCC两个主要组之间观察到显著差异。SCLC与腺癌及SCC比较，TTF-1表达有显著差异。同一病例炎症细胞未检测到TTF-1免疫反应性。结论:TTF-1与SCLC密切相关; it was weakly expressed in the various subtypes of NSCC. Although TTF-1 is not specific for SCLC, it can be used to highlight neoplastic cells to good effect when a large inflammatory component is present, and to differentiate SCLC from lymphoid infiltrates.