摘要
这项研究调查了干净的养猪场(SCB)是否比旧的和更脏的设施对呼吸系统的危害更小。8名健康志愿者以1周为间隔接触8个代表最广泛清洁范围的SCB 4小时。每位志愿者和一名技术人员对SCB的清洁度从1到10打分,1是最干净的。测量空气中的灰尘、细菌、内毒素水平、霉菌和氨。在每次暴露前和暴露后,测量每个志愿者的强迫呼气流量(强迫一秒呼气量(FEV1)和强迫肺活量)、洗鼻血和静脉血中的白细胞、鼻灌白介素(IL)-8水平和血清白介素-6水平。在基线和每次接触后均进行了甲胆碱刺激。清洁度得分在1.5-8.25之间。平均空气污染水平为:尘埃3.54 mg × m(-3)细菌4.25 × 10(5) CFU × m(-3);内毒素404 EU x m(-3);模具883 CFU x m(-3); ammonia 20.7 parts per million (ppm). Expiratory flows decreased after exposure (FEV1 from 4.8+/-0.7 to 4.4+/-0.7, p<0.001), neutrophils in the nasal wash and white blood cells increased (28.5+/-37 to 424+/-207 x 10(3), 5.4+/-1.0 to 7.4+/-1.7 x 10(9) cells x mL(-1) respectively), IL-8 increased from 158+/-311 to 2679+/-639 pg x mL(-1), IL-6 from 0.15+/-0.26 to 2.34+/-0.92 pg x mL(-1), (p<0.001). All SCB were similarly harmful. In conclusion, modern farming has not succeeded in making swine confinement buildings inoffensive to exposed subjects.