文摘
欧洲呼吸188bet官网地址学会指南支气管挑衅测试提出了节省时间的过程,这可能会导致不必要的夸张的反应。夸张的支气管收缩频率和决定因素的反应在临床和流行病学吸入乙酰甲胆碱测试设置没有被评估。作者评估:1)的流行夸张的支气管收缩,2)与节省时间的措施(醋甲胆碱浓度和跳过浓度开始);和3)这样的反应和风险因素之间的关联,呼吸道症状和/或肺功能参数。临床(n = 408)和流行病学(n = 711)组包括在内。夸张的支气管收缩被定义为一个秋天> = 20%生理盐水或>或=下跌30%在一秒钟用力呼气量(FEV1)醋甲胆碱后吸气。例相比,两组主题:1)与可衡量的支气管反应(MBR);和2)没有MBR。在流行病学组,84例(12%)呈现夸张的支气管收缩。跳过浓度占18这些夸张的支气管收缩。 In the clinical group, 41 subjects (10%) experienced exaggerated reactions. Skipped concentrations accounted for an exaggerated bronchoconstriction in five of these. The provocative concentration of methacholine causing a 20% fall in FEV1 values were marginally lower in subjects with exaggerated bronchoconstriction. Questionnaire analysis in epidemiological subjects showed some symptoms of asthma and rhinitis to be more prevalent in cases than in subjects without MBR. In conclusion, methacholine inhalation tests with time-saving measures result in a 10% risk of exaggerated bronchoconstriction as defined in this study and bronchial responsiveness is more prominent in subjects with exaggerated bronchoconstriction.