急性肺栓塞后劳累呼吸困难的患病率和潜在决定因素
- PMID:20599368
- doi:10.1016/j.rmed.2010.06.006
急性肺栓塞后劳累呼吸困难的患病率和潜在决定因素
Abstract
Background:The exact prevalence and etiology of exertional dyspnea in the clinical course of acute pulmonary embolism (PE) have not yet been established.
Methods:大量连续诊断为急性PE的患者接受了呼吸困难调查表,并邀请进行心肺检查,包括6分钟步行测试,肺活量测定法和超声心动图。评估了劳累呼吸困难的患病率,严重性,决定因素和潜在疾病。
结果:Of the registered 877 patients, 259 (30%) had died and 11 (1.3%) were excluded for geographical reasons. From the remaining 607 patients, 217 reported exertional dyspnea (36%; 95% CI 32-40%) 3.6 ± 1.7 years after the PE. In 76% this dyspnea had developed or worsened after the acute PE. 421 patients completed the cardiopulmonary work-up. Cardiopulmonary comorbidity (OR 12; 95% CI 6.5-20), advanced age (OR 1.02 per year; 95% CI 1.01-1.03), higher BMI (OR 1.06 per kg/m(2); 95% CI 1.01-1.1) and a smoking history (OR 1.6; 95% CI 1.02-2.6) were identified as independent predictors of exertional dyspnea. A pre-defined dyspnea explaining diagnosis could be established in all patients with exertional dyspnea. In only 4 patients, this diagnosis was directly correlated to the acute PE. Increased severity of dyspnea was associated with decreased exercise performance (p < 0.001) and a higher number of dyspnea-related diagnoses (p < 0.001).
Conclusion:Exertional dyspnea is a frequent symptom in the long term clinical course of acute PE. More severe dyspnea results in decreased exercise capacity and increased burden of cardiopulmonary comorbidity. This dyspnea is likely to be unrelated to the past thromboembolic event in the vast majority of patients.
版权所有©2010 Elsevier Ltd.保留所有权利。
类似的文章
-
急性肺栓塞发作后,长期随访的持续性呼吸困难:问卷的结果。Eur J Intern Med。2008 Dec;19(8):625-9. doi: 10.1016/j.ejim.2008.02.006. Epub 2008 Apr 22. Eur J Intern Med。2008。 PMID:19046730
-
The impact of post-pulmonary embolism syndrome and its possible determinants.Thromb Res. 2018 Nov;171:84-91. doi: 10.1016/j.thromres.2018.09.048. Epub 2018 Sep 15. Thromb Res. 2018. PMID:30267974
-
[动态过度充电对COPD的劳累呼吸困难,运动表现和生活质量的影响]。图伯克·托拉克斯(Tuberk Toraks)。2008; 56(3):296-303。 图伯克·托拉克斯(Tuberk Toraks)。2008。 PMID:18932031 土耳其。
-
劳累呼吸困难的临床评估。临床医学。1994 Jun;15(2):259-69. 临床医学。1994。 PMID:8088092 Review.
-
[量化呼吸困难严重程度的方法。第一部分基线呼吸困难指数(BDI),过渡呼吸困难指数(TDI)]。肺炎。2006年4月; 55(2):58-63。 肺炎。2006. PMID:17069203 Review. Romanian.
Cited by12文章
-
Association between myocardial fibrosis, as assessed with cardiac magnetic resonance T1 mapping, and persistent dyspnea after pulmonary embolism.Int J Cardiol Heart Vasc。2021年12月28日; 38:100935。doi:10.1016/j.ijcha.2021.100935。2月2022年环保。 Int J Cardiol Heart Vasc。2021。 PMID:35005213 免费PMC文章。
-
肺栓塞后呼吸困难:一项基于全国人群的病例对照研究。PULM CIRC。2021年9月30日; 11(4):20458940211046831。doi:10.1177/20458940211046831。Ecollection 2021年10月至12月。 PULM CIRC。2021。 PMID:34616546 免费PMC文章。
-
在丹麦发生事件静脉血栓栓塞后永久性与工作有关的残疾养老金的风险:一项基于人群的队列研究。PLOS MED。2021 Aug 31;18(8):e1003770. doi: 10.1371/journal.pmed.1003770. eCollection 2021 Aug. PLOS MED。2021。 PMID:34464405 免费PMC文章。
-
Pulmonology approach in the investigation of chronic unexplained dyspnea.J Bras Pneumol。2021年2月8日; 47(1):E20200406。doi:10.36416/1806-3756/e20200406。2021年环保。 J Bras Pneumol。2021。 PMID:33567064 免费PMC文章。
-
慢性血栓栓塞性肺动脉高压 - 仍在发展。Glob Cardiol Sci实践。2020年4月30日; 2020(1):E202011。doi:10.21542/gcsp.2020.11。 Glob Cardiol Sci实践。2020。 PMID:33150155 免费PMC文章。 Review.
Publication types
网格条款
链接 - 更多资源
全文来源
医疗的
各种各样的