TY - T1的气流限制全球陆ngs Initiative equations in a cohort of very old adults JF - European Respiratory Journal JO - Eur Respir J SP - 123 LP - 132 DO - 10.1183/09031936.00217214 VL - 46 IS - 1 AU - Turkeshi, Eralda AU - Vaes, Bert AU - Andreeva, Elena AU - Matheï, Catharina AU - Adriaensen, Wim AU - Van Pottelbergh, Gijs AU - Degryse, Jean-Marie Y1 - 2015/07/01 UR - //www.qdcxjkg.com/content/46/1/123.abstract N2 - The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off.In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN) and fixed cut-off (0.70) were compared with COPD reported by general practitioners (GPs). Survival and Cox regression multivariable analysis assessed the association of airflow limitation by both cut-offs with 5-year all-cause mortality and first hospitalisation at 3 years.9.2% had airflow limitation by GLI-LLN and 27% by fixed cut-off, without good agreement (kappa coefficient ≤0.40) with GP-reported COPD (9%). Only airflow limitation by GLI-LLN was independently associated with mortality (adjusted hazard ratio 2.10, 95% CI 1.30–3.38). FEV1/FVC <0.70 but ≥GLI-LLN (17.8%) had no significantly higher risk for mortality or hospitalisation.In a cohort of very old adults, airflow limitation by GLI-LLN has lower prevalence than by fixed cut-off, independently predicts all-cause mortality and does not miss individuals with significantly higher all-cause mortality and hospitalisation.Airflow limitation by GLI 2012 equations is better at predicting survival than fixed ratio in very old adults http://ow.ly/K0xMi ER -