TY - Jour T1 - Club Cell，CC10和上皮表面的自我控制JF - 欧洲呼吸期刊Jo - Eur Respir J SP - 831 LP - 832 Do - 10.1183 / 09031936.00089214 VL - 44是 - 4 Au - Hiemstra，Pieter S。Au - Bourdin，Arnaud Y1 - 2014/10/01 UR - //www.qdcxjkg.com/content/44/4/831.Abstract N2 - 我们最近有洞察力增加了控制的机制炎症，不需要的免疫应答和组织损伤。这是由对肺病中调节性T-和B细胞的作用的丰富的文学来说明，也是通过研究抗炎细胞因子如白细胞介素（IL）-10，以及微生物代谢的产物，如短 -链脂肪酸。The airway epithelium also shows clear signs of self-control, and studies on the club cell 10-kDa protein (CC10; also known as e.g. club cell secretory protein or secretoglobin family 1A member 1 (SCGB1A1)) have identified it as one of the mediators involved [1]. CC10 is a main product of club cells, which are especially abundant in the peripheral airways where they contribute to maintenance of airway integrity and repair [2]. The consequences of injury to the small airways are clear from the involvement of small airway dysfunction in an increasing number of lung diseases. Moreover, a defect in the relative abundance of CC10-expressing cells in the peripheral airways of patients with asthma, chronic obstructive pulmonary disease (COPD) and post-transplant obliterative bronchiolitis was reported … ER -