电子T1双重bronchodi RT老杂志文章lation with QVA149 reduces patient-reported dyspnoea in COPD: the BLAZE study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1599 OP 1609 DO 10.1183/09031936.00124013 VO 43 IS 6 A1 Mahler, Donald A. A1 Decramer, Marc A1 D'Urzo, Anthony A1 Worth, Heinrich A1 White, Tracy A1 Alagappan, Vijay K.T. A1 Chen, Hungta A1 Gallagher, Nicola A1 Kulich, Károly A1 Banerji, Donald YR 2014 UL //www.qdcxjkg.com/content/43/6/1599.abstract AB We evaluated the effect of QVA149, a dual bronchodilator combining indacaterol and glycopyrronium, on direct patient-reported dyspnoea in patients with moderate-to-severe chronic obstructive pulmonary disease. In this multicentre, blinded, double-dummy, three-period crossover study, 247 patients were randomised to once-daily QVA149 110/50 μg, placebo or tiotropium 18 μg. Superiority of QVA149 versus placebo (primary objective) and tiotropium (secondary objective) was assessed for improvement in dyspnoea via the self-administered computerised (SAC) version of the Baseline and Transition Dyspnoea Index after 6 weeks. Secondary end-points included lung function, rescue medication use and safety. After 6 weeks, the SAC Transition Dyspnoea Index total score was significantly higher with QVA149 versus placebo (least squares mean (LSM) treatment difference 1.37, p<0.001) and tiotropium (LSM treatment difference 0.49, p=0.021). QVA149 provided significant improvements in lung function, with higher forced expiratory volume in 1 s area under the curve from 0–4 h post-dose versus placebo and tiotropium at day 1 and week 6 (all p<0.001). Rescue medication use was significantly lower with QVA149 versus placebo (p<0.001) and tiotropium (p=0.002). All treatments were well tolerated. Once-daily QVA149 provided superior improvements in patient-reported dyspnoea and lung function versus placebo and tiotropium. These benefits were associated with improvements in other symptoms and reduced use of rescue medication. Two different bronchodilators in a single inhaler were effective in relieving patient-reported dyspnoea in COPD http://ow.ly/qjIpe