PT -期刊文章盟Quanjer Philip h . AU -Weiner, Daniel J. AU - Pretto, Jeffrey J. AU - Brazzale, Danny J. AU - Boros, Piotr W. TI - Measurement of FEF_25–75% and FEF_75% does not contribute to clinical decision making AID - 10.1183/09031936.00128113 DP - 2014 Apr 01 TA - European Respiratory Journal PG - 1051--1058 VI - 43 IP - 4 4099 - //www.qdcxjkg.com/content/43/4/1051.short 4100 - //www.qdcxjkg.com/content/43/4/1051.full SO - Eur Respir J2014 Apr 01; 43 AB - The aim of this study was to determine the added value of measuring the forced expiratory flow at 25–75% of forced vital capacity (FVC) (FEF25–75%) and flow when 75% of FVC has been exhaled (FEF75%) over and above the measurement of the forced expiratory volume in 1 s (FEV1), FVC and FEV1/FVC ratio. We used spirometric measurements of FEV1, FVC and FEF25–75% from 11 654 white males and 11 113 white females, aged 3–94 years, routinely tested in the pulmonary function laboratories of four tertiary hospitals. FEF75% was available in 8254 males and 7407 females. Predicted values and lower limits of normal, defined as the fifth percentile, were calculated for FEV1, FVC, FEV1/FVC ratio, FEF25–75% and FEF75% using prediction equations from the Global Lung Function Initiative. There was very little discordance in classifying test results. FEF25–75% and FEF75% were below the normal range in only 2.75% and 1.29% of cases, respectively, whereas FEV1, FVC and FEV1/FVC ratio were within normal limits. Airways obstruction went undetected by FEF25–75% in 2.9% of cases and by FEF75% in 12.3% of cases. Maximum mid-expiratory flow and flow towards the end of the forced expiratory manoeuvre do not contribute usefully to clinical decision making over and above information from FEV1, FVC and FEV1/FVC ratio. Forced expiratory flow measurements do not contribute usefully to clinical decision making http://ow.ly/t6Xz1