作者@article {Koponen76 = {Koponen, p和冥界minen, M. and Paassilta, M. and Luukkaala, T. and Korppi, M.}, title = {Preschool asthma after bronchiolitis in infancy}, volume = {39}, number = {1}, pages = {76--80}, year = {2012}, doi = {10.1183/09031936.00040211}, publisher = {European Respiratory Society}, abstract = {Asthma risk is lower after wheezing associated with respiratory syncytial virus (RSV) than with non-RSV infection in infancy. RSV is the main wheezing-associated virus in infants aged \<6 months. We evaluated the outcome of children hospitalised for bronchiolitis at \<6 months of age, with special focus on viral aetiology and early risk factors. Out of 205 infants hospitalised for bronchiolitis at \<6 months of age, 127 (62\%) attended a control visit at a mean age of 6.5 yrs and the parents of an additional 39 children were interviewed by telephone. Thus, follow-up data collected by identical structured questionnaires were available from 166 (81\%) children. Viral aetiology of bronchiolitis, studied on admission by antigen detection or PCR, was demonstrable in 97\% of cases. Current asthma was present in 21 (12.7\%) children: 8.2\% in the 110 former RSV patients versus 24\% in non-RSV patients (p=0.01). 45 (27\%) children had ever had asthma. In adjusted analyses, atopic dermatitis, non-RSV bronchiolitis and maternal asthma were independently significant early-life risk factors for asthma. The risk of asthma was lower after RSV bronchiolitis than after bronchiolitis caused by other viruses in children hospitalised at \<6 months of age.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/39/1/76}, eprint = {//www.qdcxjkg.com/content/39/1/76.full.pdf}, journal = {European Respiratory Journal} }