ty -jour t1-氨基氨基氨酸对大鼠diaphragm jf功能和细胞内pH的影响 - 欧洲呼吸杂志Au -Cameron，ir Y1-1990/101 ur -http：//www.qdcxjkg.com/content/3/9/991.abstract n2-我们研究了氨基氨叶素对Twitch张力（TT）和细胞内pH的影响（PHI）在疲劳，高碳酸盐或低氧的分离大鼠隔膜条中。在0.5 Hz处直接刺激超融合的肌肉。PHI是根据二甲基 - 恶唑二酮的分布体积测量的。间歇性破坏刺激引起疲劳。高碳酸盐和缺氧是通过改变二氧化碳张力（PCO2）或氧张力（PO2）来产生的。氨基氨叶氨酸（1.0 mmol.l-1）逆转了在疲劳或高含量酸中毒过程中看到的抽搐衰减，并导致缺氧期间抽搐抑郁症的部分恢复。肌肉疲劳不是由于细胞内酸中毒引起的。高碳酸盐和低氧降低了PHI。 Aminophylline did not alter pHi in unstimulated muscles, but caused a significant fall in pHi in stimulated muscles that were fatigued or hypoxic. High dose aminophylline improved twitch tension in diaphragm strips that were fatigued, acidotic, or hypoxic. Twitch potentiation was not due to an intracellular alkalosis. Aminophylline lowered pHi in stimulated muscle, and thus, theoretically, could sometimes be harmful in the treatment of muscle fatigue. ER -